Ultraviolet irradiation alters transforming growth factor β/Smad pathway in human skin in vivo

Journal of Investigative Dermatology

Volumn 119, Issue 2, 2002, Pages 499-506

  Quan, TaiHao ^a   He, TianYuan ^a   Kang, Sewon ^a   Voorhees, John J ^a   Fisher, Gary J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Human skin; Smad pathway; TGF ; Ultraviolet

Indexed keywords

DNA; ISOPROTEIN; MESSENGER RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; ARTICLE; CONTROLLED STUDY; DERMIS; EPIDERMIS; ERYTHEMA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; IN VIVO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION; ULTRAVIOLET IRRADIATION;

EID: 0036038264     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01834.x     Document Type: Article

References (58)

1. Common fluorescent sunlamps are an inappropiate substitute for sunlight
2. Interaction of Smad3 with a proximal Smad-binding element of the human α2(I) procollagen gene promoter required for transcriptional activiation of TGF-β
3. An AP-1 binding sequence is essential for regulation of the human α2(I) collagen (COL1A2) promoter activity by transforming growth factor β
4. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
5. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
6. Identification of another member of the transforming growth factor type β gene family
7. Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vivo
8. Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin
9. All-trans retinoic acid induces cellular retinol-binding protein in human skin in vivo
10. Molecular basis of sun-induced premature skin ageing and retinoid antagonism
11. Pathophysiology of premature skin aging induced by ultraviolet light
12. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo
13. Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid
14. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid
15. The TGFβ2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis
16. Photodermatology: Progress, problems and prospects
17. Photobiology 102. UV sources and dosimetry - The proper use and measurement of 'photons as a reagent'
18. Regulation of the transforming growth factor-β1 and -β3 promoters by transcription factor Sp1
19. TGF-β isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis
20. TGFbeta signaling and cancer
21. Transforming growth factor β stimulates α2 collagen gene expression through a cis-acting element that contains an S binding site
22. Complementary deoxynucleic acid clioning of a novel transforming growth factor-β messenger ribonucleic acid from chick embryo chondrocytes
23. Functional analog of human α1(I) procollagen gene promoter: Differential activity in collagen producing and nonproducing cells and response to transforming growth factor β1
24. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicate defects of epithelial-mesenchymal interaction
25. Characterization of the promoter region of the human transforming growth factor-β1 gene
26. Immunosuppression by factors released from UV-irradiated epidermal cells: Selective effects on generation of contact and delayed hypersensitivity after exposure to UVA radiation
27. Transforming growth factor-β and breast cancer. Transforming growth factor-β/SMAD signaling defects and cancer
28. Transforming growth factor beta I null mutation in mice causes excessive inflammatory response and early death
29. Responsiveness to transforming growth factor-beta (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II
30. TGF-β receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesis
31. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
32. The transforming growth factor β family
33. TGF-β signal transduction
34. Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-β
35. Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signalling
36. Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor β2 promoter
37. Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
38. Transforming growth factor β increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability
39. Specificity, diversity, and regulation in TGF-β superfamily signaling
40. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
41. Transforming growth factor-beta 3 is required for secondary palate fusion
42. Cloning and characterization of the human protein kinase c-η promoter
43. Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its type II receptor and inducing Smad7
44. Frequency of Smad gene mutations in human cancers
45. Transforming growth factor-β: Multiple effects on cell differentiation and extracellular matrices
46. TGF-beta: Regulation of extacellular matrix
47. Regulation of type I collagen synthesis
48. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
49. Targeted disruption of the mouse transforming growth factor-beta I gene results in multifocal inflammatory disease
50. Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium
51. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
52. Tumor necrosis factor-alpha inhibits transforming growth factor-beta/Smad signaling in human dermal fibroblasts via AP-1 activation
53. Role of TGFbeta signaling in skin carinogenesis
54. Feedback from inhibitory SMADs
55. The transforming growth factor-beta signaling pathway in tumorigenesis
56. The role of TGFbeta in human cancers
57. The Smad pathway
58. Human Smad 3 and Smad 4 are sequence-specific transcription activators