UV irradiation induces downregulation of bcl-2 expression in vitro and in vivo

Archives of Dermatological Research

Volumn 291, Issue 4, 1999, Pages 212-216

  Isoherranen, Kirsi ^a,c   Sauroja, Ilari ^a   Jansen, Christer ^a   Punnonen, Kari ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Apoptosis; bax; bcl 2; Solar simulated irradiation; UV irradiation

Indexed keywords

MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; FLOW CYTOMETRY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; TIME; ULTRAVIOLET IRRADIATION;

ADULT; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DNA FRAGMENTATION; FLOW CYTOMETRY; GENE EXPRESSION; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SKIN; ULTRAVIOLET RAYS;

EID: 0032904735     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030050396     Document Type: Article

References (37)

1. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Br J Cancer 26:239-257
2. Wyllie AH (1993) Apoptosis. Br J Cancer 67:205-208
3. Ueda N, Shah SV (1994) Apoptosis. J Lab Clin Med 124:169-177
4. Young AR (1987) The sunburn cell. Photodermatology 4:127-134
5. Gniadecki, R, Hansen M, Wulf HC (1997) Two pathways for induction of apoptosis by ultraviolet radiation in cultured human keratinocytes. J Invest Dermatol 109:163-169
6. Schwarz A, Bhardwaj R, Aragane Y, Mahnke K, Riemann H, Metze D, Luger TA, Schwarz T (1995) Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-α in the formation of sunburn cells. J Invest Dermatol 104:922-927
7. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelnan J, Remington L, Jacks T, Brash DE (1994) Sunburn and p53 in the onset of skin cancer. Nature 372:773-776
8. Haake AR, Polakowska RR (1995) UV-induced apoptosis in skin equivalents: inhibition by phorbol esters and Bcl-2 over-expression. Cell Death Differ 2:183-193
9. Gillardon F, Eschenfelder C, Uhlmann E, Hartschuh W, Zimmermann M (1994) Differential regulation of c-fos, fosB, c-jun, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene 9:3219-3225
10. Pourzand C, Rossier G, Reelfs O, Borner C, Tyrrell RM (1997) The overexpression of Bcl-2 inhibits UVA-mediated immediate apoptosis in rat 6 fibroblasts: evidence for involvement of Bcl-2 as an antioxidant. Cancer Res 57:1405-1411
11. Tsujimoto Y, Cossman J, Jaffe E, Croce CM (1985) Involvement of the bcl-2 gene in follicular lymphoma. Science 228:1440-1443
12. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6
13. Martin, SJ, Newmeyer DD, Mathias S, Farschon DM, Wang H, Reed JC, Kolesnick RN, Green DR (1995) Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis. EMBO J 14:5191-5200
14. Zhai S, Yaar M, Doyle SM, Gilchrest BA (1996) Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating bcl-2 levels. Exp Cell Res 224:335-343
15. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74:609-619
16. Li G, Mitchell DL, Ho VC, Reed JC, Tron VA (1996) Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice. Am J Pathol 148:1113-1123
17. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279
18. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ (1983) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5924-5929
19. Thomas PS (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A 77:5201-5205
20. Nunez G, Seto M, Seremetis S, Ferrero D, Grignani F, Korsmeyer SJ, Dalla-Favera R (1989) Growth- and tumor-promoting effects of deregulated bcl-2 in human B-lymphoblastoid cells. Proc Natl Acad Sci USA 86:4589-4593
21. Fort P, Marty L, Piechaczyk M, El Sabrouty S, Dani C, Jeanteur P, Blanchard JM (1985) Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res 13:1431-1442
22. Snellman E, Jansen CT, Leszczynski K, Visuri R, Milan T, Jokela K (1995) Ultraviolet erythema sensitivity in anamnestic (I-IV) and phototested (1-4) caucasian skin phototypes: the need for a new classification system. Photochem Photobiol 62:769-772
23. Liang XH, Mungal S, Ayscue A, Meissner JD, Wodnicki P, Hockenbery D, Lockett S, Herman B (1995) Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J Cell Biochem 57:509-521
24. Butz K, Shahabeddin L, Geisen C, Spitkovsky D, Ullmann A, Hoppe-Seyler F (1995) Functional p53 protein in human papillomavirus-positive cancer cells. Oncogene 10:927-936
25. Martin SJ, Cotter TG (1991) Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis. Int J Radiat Biol 59:1001-1016
26. Zhan Q, Fan S, Bae I, Guillou C, Liebermann DA, O'Connor PM, Fomace Jr AJ (1994) Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9:3743-3751
27. Butz K, Geisen C, Ullmann A, Spitkovsky D, Hoppe-Seyler F (1996) Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis. Int J Cancer 68:506-513
28. Daniels F, Brophy D, Lobitz W (1961) Histochemical responses of human skin following ultraviolet irradiation. J Invest Dermatol 37:351-357
29. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965
30. Rodriguez-Villanueva J, Colome MI, Brisbay S, McDonnell TJ (1995) The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers. Pathol Res Pract 191:391-398
31. Sermadiras S, Dumas M, Joly-Berville R, Bonte F, Meybeck A, Ratinaud MH (1997) Expression of Bcl-2 and Bax in cultured normal human keratinocytes and melanocytes: relationship to diffentiation and melanogenesis. Br J Dermatol 137:883-889
32. Bayerl C, Taake S, Moll I, Jung E (1995) Characterization of sunburn cells after exposure to ultraviolet light. Photodermatol Photoimmunol Photomed 11:149-154
33. Hockenbery DM, Oltvai ZN, Yin X, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251
34. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
35. Lithgow T, van Driel R, Bertram JF, Strasser A (1994) The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ 5:411-417
36. Punnonen K, Puntala A, Jansen CT, Ahotupa M (1991) UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities in human keratinocytes in vitro. Acta Derm Venereol 71:239-273
37. Punnonen K, Autio P, Kiistala U, Ahotupa M (1991) In-vivo effects of solar-simulated ultraviolet irradiation on antioxidant enzymes and lipid peroxidation in human epidermis. Br J Dermatol 125:8-20