GAD65-mediated Glutamate Decarboxylation Reduces Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

Journal of Biological Chemistry

Volumn 276, Issue 39, 2001, Pages 36391-36396

  Rubi, Blanca ^a,b   Ishihara, Hisamitsu ^a   Hegardt, Fausto G ^b   Wollheim, Claes B ^a   Maechler, Pierre ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GLUCOSE; METABOLISM;

DECARBOXYLATION;

INSULIN;

ADENOVIRUS VECTOR; CALCIUM; GLUCOSE; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65; GLUTAMIC ACID; INSULIN; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID DERIVATIVE; ISOENZYME; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; DECARBOXYLATION; ENZYME ACTIVITY; EXOCYTOSIS; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ADENOVIRUS; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; CYTOSOL; FLUORESCENCE MICROSCOPY; GENETIC TRANSDUCTION; GENETICS; IMMUNOBLOTTING; METABOLISM; MITOCHONDRION; PANCREAS ISLET; PROTEIN BINDING; SECRETION; TIME;

ADENOVIRIDAE; ANIMALIA;

ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ANIMALS; CALCIUM; CELLS, CULTURED; CYTOSOL; EXOCYTOSIS; GLUCOSE; GLUTAMATE DECARBOXYLASE; GLUTAMATES; GLUTAMIC ACID; HUMANS; IMMUNOBLOTTING; INSULIN; ISLETS OF LANGERHANS; ISOENZYMES; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; TIME FACTORS; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035965364     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104999200     Document Type: Article

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