Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells

IUBMB Life

Volumn 50, Issue 1, 2000, Pages 27-31

  Maechler, Pierre ^a   Antinozzi, Peter A ^a   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Exocytosis; Glutamate dehydrogenase; Insulin; Oxygen consumption; Succinate

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLYCEROPHOSPHATE; INSULIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CITRIC ACID CYCLE; CONTROLLED STUDY; EXOCYTOSIS; INSULIN RELEASE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; RAT;

ANIMAL; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLYCEROPHOSPHATES; HORMONES; HUMAN GROWTH HORMONE; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MITOCHONDRIA; OXYGEN; PANCREATIC NEOPLASMS; RATS; SUCCINATES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; UNCOUPLING AGENTS;

EID: 0033788473     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540050176557     Document Type: Article

References (25)

1. Metabolic coupling factors in pancreatic β-cell signal transduction
2. New insights into pancreatic β-cell metabolic signaling in insulin secretion
3. Beta-cell mitochondria in the regulation of insulin secretion: A new culprit in Type II diabetes
4. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
5. 2+ and G-proteins
6. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
7. + channels in mouse B cells
8. 2+ influx in rat pancreatic B-cell
9. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells
10. 2+ and insulin secretion responses in the beta cell
11. Glutamate acts as a mitochondrially derived messenger in glucose-induced insulin exocytosis
12. 13C NMR analysis
13. L-Glutamate dehydrogenases: Distribution, properties and mechanism
14. Free radical modulation of insulin release in INS-1 cells exposed to alloxan
15. Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta-cells
16. Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells
17. 2+ revealed by specifically targeted recombinant aequorin
18. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
19. Newer aspects of glutamine/glutamate metabolism: The role of acute pH changes
20. Need for inorganic phosphate in oxidations stimulated by dinitrophenol
21. Control of respiration and ATP synthesis in mammalian mitochondria and cells
22. Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells
23. High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide
24. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
25. Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics