Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias

Virchows Archiv

Volumn 446, Issue 2, 2005, Pages 120-126

  Homma, Naoyuki ^a   Tamura, Gen ^a   Honda, Teiichiro ^a   Jin, Zhe ^a   Ohmura, Kiyonari ^a   Kawata, Sumio ^a   Motoyama, Teiichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

CHfr; Gastric cancer; hMLH1; Hypermethylation

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CANCER PATIENT; CHECKPOINT WITH FORKHEAD ASSOCIATED AND RING FINGER GENE; CHROMOSOMAL INSTABILITY; CHROMOSOME LOSS; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; HETEROZYGOSITY; HMLH1 GENE; HUMAN; IMMUNOREACTIVITY; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLE; SENESCENCE; STOMACH ADENOCARCINOMA; STOMACH CARCINOMA; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH TUMOR; SUBMUCOSA;

AGED; AGING; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMOSOMAL INSTABILITY; DNA METHYLATION; FEMALE; GENES, P53; HUMANS; MALE; MICROSATELLITE REPEATS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

EID: 15244340291     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-004-1146-6     Document Type: Article

References (42)

1. Abad M, Ciudad J, Rincon MR, Silva I, Paz-Bouza JI, Lopez A, Alonso AG, Bullon A, Orfao A (1998) DNA aneuploidy by flow cytometry is an independent prognostic factor in gastric cancer. Anal Cell Pathol 16:223-231
2. Aquilina G, Crescenzi M, Bignami M (1999) Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage. Carcinogenesis 20:2317-2326
3. Bara J, Gautier R, Mouradian P, Decaens C, Daher N (1991) Oncofetal mucin M1 epitope family: characterization and expression during colonic carcinogenesis. Int J Cancer 47:304-310
4. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S (1998) A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257
5. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392:300-303
6. Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (1999) Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 58:181-187
7. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, Hamelin R, Carneiro F, Seruca R (2003) Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. Eur J Cancer 39:1222-1227
8. Cejka P, Stojic L, Mojas N, Russell AM, Heinimann K, Cannavo E, diPietro M, Marra G, Jiricny J (2003) Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO J 22:2245-2254
9. Chaturvedi P, Sudakin V, Bobiak ML, Fisher PW, Mattern MR, Jablonsk SA, Hurle MR, Zhu Y, Yen TJ, Zhou BB (2002) Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res 62:1797-1801
10. Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS (2003) Frequent hypermethylation of the 5′ CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis 24:47-51
11. Danielsen EM, Vyas JP, Kenny AJ (1980) A neutral endopeptidase in the microvillar membrane of pig intestine: Partial purification and properties. Biochem J 191:645-648
12. Endoh Y, Tamura G, Ajioka Y, Watanabe H, Motoyama T (2000) Frequent hypermethylation of hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. Am J Pathol 157:717-722
13. Gemma A, Seike M, Seike Y, Uematsu K, Hibino S, Kurimoto F, Yoshimura A, Shibuya M, Harris CC, Kudoh S (2000) Somatic mutation of the BUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 29:213-218
14. Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland CR, Koi M (1995) Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 55:3721-3725
15. Honda T, Tamura G, Waki T, Kawata S, Nishizuka S, Motoyama T (2004) Promoter hypermethylation of Chfr gene in neoplastic and non-neoplastic gastric epithelia. Br J Cancer 90:2013-2016
16. Imai Y, Shiratori Y, Kato N, Inoue T, Omata M (1999) Mutational inactivation of mitotic checkpoint genes, hsMAD2 and BUB1, is rare in sporadic digestive tract cancers. Jpn J Cancer Res 90:837-840
17. Jin Z, Tamura G, Honda T, Motoyama T (2002) Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia. Lab Invest 82:1637-1645
18. Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21:163-167
19. Kang D, Chen J, Wong J, Fang G (2002) The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J Cell Biol 156:249-259
20. Kim H, Kim YH, Kim SE, Kim NG, Noh SH, Kim H (2003) Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. J Pathol 200:23-31
21. Lee JH, Abraham SC, Kim HS, Nam JH, Choi C, Lee MC, Park CS, Juhng SW, Rashid A, Hamilton SR, Wu TT (2002) Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. Am J Pathol 161:611-618
22. Lengauer C, Kinzeler KW, Vogelstein B (1998) Genetic instabilities in human cancer. Nature 396:643-649
23. Li Y, Benezra R (1996) Identification of a human mitotic checkpoint gene: hsMAD2. Science 274:246-248
24. Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA (2001) Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 61:5193-5201
25. Mitelman F (1994) Chromosomes, genes, and cancer. CA Cancer J Clin 44:133-135
26. Mizuno K, Osada H, Konishi H, Tatematsu Y, Yatabe Y, Mitsudomi T, Fujii Y, Takahashi T (2002) Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 21:2328-2333
27. Nishizuka S, Tamura G, Terashima M, Satodate R (1998) Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach. J Pathol 185:38-43
28. Ogata S, Tamura G, Endoh Y, Sakata Y, Ohmura K, Motoyama T (2001) Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer. J Pathol 194:334-340
29. Ohmura K, Tamura G, Endoh Y, Sakata K, Takahashi T, Motoyama T (2000) Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of stomach with special reference to cellular phenotype. Hum Pathol 31:1031-1035
30. Paz MF, Avila S, Fraga MF, Pollan M, Capella G, Peinado MA, Sanchez-Cespedes M, Herman JG, Esteller M (2002) Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 62:4519-4524
31. Rugge M, Correa P, Dixon MF, Hattori T, Leandro G, Lewin K, Riddell RH, Sipponen P, Watanabe H (2000) Gastric dysplasia: The Padova international classification. Am J Surg Pathol 24:167-176
32. Sakata K, Tamura G, Endoh Y, Ohmura K, Ogata S, Motoyama T (2002) Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability. Br J Cancer 86:564-567
33. Scolnick DM, Halazonetis TD (2000) Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406:430-435
34. Shibata Y, Haruki N, Kuwabara Y, Ishiguro H, Shinoda N, Sato A, Kimura M, Kayama H, Toyama T, Nishiwaki T, Kudo J, Terashita Y, Konishi S, Sugiura H, Fujii Y (2002) Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer. Carcinogenesis 23:1695-1699
35. Tamura G (1996) Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach. Pathol Int 46:834-841
36. Tamura G (2002) Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer. Histol Histopathol 17:323-329
37. Tamura G, Kihana T, Nomura K, Terada M, Sugimura T, Hirohashi S (1991) Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis. Cancer Res 51:3056-3058
38. Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Terashima M, Eda Y, Satodate R (1996) Allelotype of adenoma and differentiated adenocarcinoma of the stomach. J Pathol 180:371-377
39. Tamura G, Sato K, Akiyama S, Tsuchiya T, Endoh Y, Usuba O, Kimura W, Nishizuka S, Motoyama T (2001) Molecular characterization of undifferentiated -type gastric carcinoma. Lab Invest 81:593-598
40. Toyota M, Sasaki Y, Satoh A, Ogi K, Kikuchi T, Suzuki H, Mita H, Tanaka N, Itoh F, Issa JP, Jair KW, Schuebel KE, Imai K (2003) Epigenetic inactivation of Chfr in human tumors. Proc Natl Acad Sci U S A 100:7818-7823
41. Tytgat KM, Buller HA, Opdam FJ, Kim YS, Einerhand AW, Dekker J (1994) Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Gastroenterology 107:1352-1363
42. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T (2002) Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol 161:399-403