Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia

American Journal of Pathology

Volumn 161, Issue 2, 2002, Pages 399-403

  Waki, Takayoshi ^a   Tamura, Gen ^a   Tsuchiya, Takashi ^a   Sato, Kiyoshi ^a   Nishizuka, Satoshi ^b   Motoyama, Teiichi ^b  

^a YAMAGATA UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; PROTEIN P16; UVOMORULIN;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOPSY; CANCER RISK; CANCER SCREENING; CANCER SURGERY; CARCINOGENESIS; CHILD; CONTROLLED STUDY; FEMALE; FETUS; GENE SILENCING; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; METHYLATION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; STOMACH BIOPSY; STOMACH CANCER; STOMACH EPITHELIUM; TUMOR SUPPRESSOR GENE;

EID: 0036966214     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64195-8     Document Type: Article

References (19)

1. Kass SU, Pruss D, Wolffe AP: How does DNA methylation repress transcription? Trends Genet 1997, 13:444-449
2. Razin A, Cedar H: DNA methylation and gene expression. Microbiol Rev 1991, 55:451-458
3. Jones PA, Laird PW: Cancer epigenetics comes of age. Nat Genet 1999, 2:163-167
4. Esteller M, Corn PG, Baylin SB, Herman JG: A gene hypermethylation profile of human cancer. Cancer Res 2001, 61:3225-3229
5. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994, 7:536-540
6. Issa JP, Vertino PM, Boehm CD, Newsham IF, Baylin SB: Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci USA 1996, 93:11757-11762
7. Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP: Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 1998, 58:5489-5494
8. Issa JP: CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 2000, 249:101-118
9. Suzuki H, Itoh F, Toyota M, Kikuchi T, Kakiuchi H, Hinoda Y, Imai K: Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. Int J Cancer 1999, 83:309-313
10. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ: E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 2000, 92:569-573
11. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999, 59:1090-1095
12. Schneider BG, Gulley ML, Eagan P, Bravo JC, Mera R, Geradts J: Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach. Hum Pathol 2000, 31:45-50
13. Endoh Y, Tamura G, Ajioka Y, Watanabe H, Motoyama T: Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. Am J Pathol 2000, 157:717-722
14. Leung WK, Yu J, Ng EK, To KF, Ma PK, Lee TL, Go MY, Chung SC, Sung JJ: Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. Cancer 2001, 91:2294-2301
15. Kang GH, Shim YH, Jung HY, Kim WH, Ro JY, Rhyu MG: CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 2001, 61:2847-2851
16. Bornman DM, Mathew S, Alsruhe J, Herman JG, Gabrielson E: Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am J Pathol 2001, 159: 831-835
17. Tamura G, Sato K, Akiyama S, Tsuchiya T, Endoh Y, Usuba O, Kimura W, Nishizuka S, Motoyama T: Molecular characterization of undifferentiated-type gastric carcinoma. Lab Invest 2001, 81:593-598
18. Nakajima T, Akiyama Y, Shiraisi J, Arai T, Yanagisawa Y, Ara M, Fukuda Y, Sawabe M, Saitoh K, Kamiyama R, Hirokawa K, Yuasa Y: Age-related hypermethylation of the hMLH1 promoter in gastric cancers Int J Cancer 2001, 94:208-211
19. Sakata K, Tamura G, Ogata S, Ohmura K, Endoh Y, Motoyama T: Hypermethylation of hMLH1 promoter in solitary and multiple gastric cancers with microsatellite instability. Br J Cancer 2002, 86:564-567