Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer

Histology and Histopathology

Volumn 17, Issue 1, 2002, Pages 323-329

  Tamura, Gen ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

E cadherin; Gastric cancer; hMLH1; Methylation; p53

Indexed keywords

ACTIVATED PROTEIN C; PROTEIN P53; UVOMORULIN;

CANCER GROWTH; DNA METHYLATION; DNA REPAIR; GENE MUTATION; GENE STRUCTURE; GENETIC ASSOCIATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HETEROZYGOSITY; HISTOLOGY; HUMAN; INTESTINE METAPLASIA; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOLECULAR MECHANICS; MUTATOR GENE; NONHUMAN; PATHOGENESIS; REVIEW; SOMATIC CELL GENETICS; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH MUCOSA; TUMOR SUPPRESSOR GENE; UNDIFFERENTIATED CARCINOMA;

ANIMALS; GENES, TUMOR SUPPRESSOR; HUMANS; MICROSATELLITE REPEATS; MUTATION; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS); STOMACH NEOPLASMS;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 0036165983     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers
2. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
3. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predispositon: Development on international criteria for the determination of microsatellite instability in colorectal cancer
4. Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis
5. Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways
6. Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype
7. Author's reply
8. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
9. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability
10. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
11. Identification of germ-line E-cadherin mutation in gastric cancer families of European origin
12. E-cadherin germline mutations in familial gastric cancer
13. Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa
14. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer
15. Incidence and functional consequence of hMLH1 promoter hypermethylation in colorectal carcinoma
16. The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer
17. CpG-island methylation in aging and cancer
18. The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma
19. Absence of BAT-26 instability in gastric intestinal metaplasia
20. Cancer epigenetics comes of age
21. Accumulated frameshift mutations at coding nucleotide repeats during the progression of gastric carcinoma with microsatellite instability
22. Differential p53 protein expressin in stomach adenomas of gastric and intestinal phenotypes: Possible sequences of p53 alteration in stomach carcinogenesis
23. The two histological main types of gastric carcinoma; Diffuse and so-called intestinal type carcinoma. An attempt at a histochemical classification
24. Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer
25. p53, the cellular gatekeeper for growth and division
26. E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas
27. The sequential accumulation of genetic alterations characteristic of the colorectal adenomacarcinoma sequence does not occur between gatric adenoma and adenocarcinoma
28. Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer
29. Germ-line mutations of the APC in 53 familial adenomatous polyposis patients
30. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
31. E-cadherin gene mutation in signet ring cell carcinoma of the stomach
32. Depressed adenoma of the stomach
33. Carcinoma of the stomach in incipient phase: Its histogenesis and histological appearances
34. Microsatellite instability in multiple gastric cancers
35. Analysis of the DPC4 gene in gastric carcinoma
36. Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach
37. Loss of heterozygosity during development and progression of differentiated adenocarcinoma of the stomach
38. Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer
39. p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia
40. Microsatellite alterations and target gene mutations in the early stage of multiple gastric cancer
41. Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of the stomach: With special reference to cellular phenotype
42. Microsatellite instability: The mutator that mutates the other mutator
43. p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type
44. Gastric dysplasia: The Padova international classification
45. Disruption of E-cadherin-mediated cell adhesion systems in gastric cancers in young patients
46. Loss of heterozygosity on the short arm of chromosome 9 without p16 gene mutation in gastric carcinomas
47. Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach
48. Hypermethylation of hMLH1 promoter in solitary and multiple gastric cancers with microsatellite instability
49. Frequent loss of expression without sequence mutations in the DCC gene in gastric cancer
50. Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer
51. Differences in diagnostic criteria for gastric carcinoma between Japanese and western pathologists
52. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma
53. Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1 (17q21) in young patients with gastric cancer
54. Distinct methylation pattern and microsatellite instability in sporadic gastric cancer
55. Genetic alterations in human gastrointestinal cancers: The application to molecular diagnosis
56. Cadherin cell adhesion receptors as a morphogenetic regulator
57. Detection of p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis
58. Primary gastric carcinoma cells frequently lose heterozygosity at the APC and MCC genetic loci
59. Mutations of the APC gene occur during early stages of gastric adenoma development
60. Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach
61. Authors' reply
62. Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach
63. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach
64. Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines
65. Allelotype of adenoma and differentiated adenocarcinoma of the stomach
66. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas
67. Molecular characterization of undiffirentiated type gastric carcinoma
68. Histogenesis of human stomach cancers based on assessment of differentiation
69. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia
70. p53 mutation in gastric cancer: A genetic model for carcinogenesis is common to gastric and colorectal cancer
71. Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes
72. Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features