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Volumn 5, Issue 2, 2004, Pages 115-120

Modeling the cancer patient with genetically engineered mice: Prediction of toxicity from molecule-targeted therapies

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 1442285909     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(04)00032-7     Document Type: Review
Times cited : (44)

References (63)
  • 1
    • 0036316351 scopus 로고    scopus 로고
    • Renal failure associated with the use of celecoxib and rofecoxib
    • Ahmad S.R., Kortepeter C., Brinker A., Chen M., Beitz J. Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf. 25:2002;537-544.
    • (2002) Drug Saf. , vol.25 , pp. 537-544
    • Ahmad, S.R.1    Kortepeter, C.2    Brinker, A.3    Chen, M.4    Beitz, J.5
  • 2
    • 0038666476 scopus 로고    scopus 로고
    • Clinical Trial Design and End Points for Epidermal Growth Factor Receptor-targeted Therapies: Implications for Drug Development and Practice
    • Arteaga C.L., Baselga J. Clinical Trial Design and End Points for Epidermal Growth Factor Receptor-targeted Therapies. Implications for Drug Development and Practice Clin. Cancer Res. 9:2003;1579-1589.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1579-1589
    • Arteaga, C.L.1    Baselga, J.2
  • 3
    • 0037309702 scopus 로고    scopus 로고
    • Cardiovascular thrombotic events and COX-2 inhibitors: Results in patients with osteoarthritis receiving rofecoxib
    • Bannwarth B., Ravaud P., Dougados M. Cardiovascular thrombotic events and COX-2 inhibitors. results in patients with osteoarthritis receiving rofecoxib J. Rheumatol. 30:2003;421-422.
    • (2003) J. Rheumatol. , vol.30 , pp. 421-422
    • Bannwarth, B.1    Ravaud, P.2    Dougados, M.3
  • 4
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J., Rischin D., Ranson M., Calvert H., Raymond E., Kieback D.G., Kaye S.B., Gianni L., Harris A., Bjork T.et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J. Clin. Oncol. 20:2002;4292-4302.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3    Calvert, H.4    Raymond, E.5    Kieback, D.G.6    Kaye, S.B.7    Gianni, L.8    Harris, A.9    Bjork, T.10
  • 5
    • 0032525784 scopus 로고    scopus 로고
    • The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
    • Britsch S., Li L., Kirchhoff S., Theuring F., Brinkmann V., Birchmeier C., Riethmacher D. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12:1998;1825-1836.
    • (1998) Genes Dev. , vol.12 , pp. 1825-1836
    • Britsch, S.1    Li, L.2    Kirchhoff, S.3    Theuring, F.4    Brinkmann, V.5    Birchmeier, C.6    Riethmacher, D.7
  • 6
    • 0035724536 scopus 로고    scopus 로고
    • Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
    • Busam K.J., Capodieci P., Motzer R., Kiehn T., Phelan D., Halpern A.C. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br. J. Dermatol. 144:2001;1169-1176.
    • (2001) Br. J. Dermatol. , vol.144 , pp. 1169-1176
    • Busam, K.J.1    Capodieci, P.2    Motzer, R.3    Kiehn, T.4    Phelan, D.5    Halpern, A.C.6
  • 9
    • 0037317840 scopus 로고    scopus 로고
    • Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
    • Chene P. Inhibiting the p53-MDM2 interaction. an important target for cancer therapy Nat. Rev. Cancer. 3:2003;102-109.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 102-109
    • Chene, P.1
  • 12
    • 0037427027 scopus 로고    scopus 로고
    • Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system
    • Crone S.A., Negro A., Trumpp A., Giovannini M., Lee K.F. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron. 37:2003;29-40.
    • (2003) Neuron , vol.37 , pp. 29-40
    • Crone, S.A.1    Negro, A.2    Trumpp, A.3    Giovannini, M.4    Lee, K.F.5
  • 14
    • 0038724672 scopus 로고    scopus 로고
    • Targeting the TGF beta signaling network in human neoplasia
    • Dumont N., Arteaga C.L. Targeting the TGF beta signaling network in human neoplasia. Cancer Cell. 3:2003;531-536.
    • (2003) Cancer Cell , vol.3 , pp. 531-536
    • Dumont, N.1    Arteaga, C.L.2
  • 15
    • 0033639223 scopus 로고    scopus 로고
    • Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis
    • Egger B., Buchler M.W., Lakshmanan J., Moore P., Eysselein V.E. Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis. Scand. J. Gastroenterol. 35:2000;1181-1187.
    • (2000) Scand. J. Gastroenterol. , vol.35 , pp. 1181-1187
    • Egger, B.1    Buchler, M.W.2    Lakshmanan, J.3    Moore, P.4    Eysselein, V.E.5
  • 16
    • 0031454062 scopus 로고    scopus 로고
    • ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2-and heregulin-deficient mice
    • Erickson S.L., O'Shea K.S., Ghaboosi N., Loverro L., Frantz G., Bauer M., Lu L.H., Moore M.W. ErbB3 is required for normal cerebellar and cardiac development. a comparison with ErbB2-and heregulin-deficient mice Development. 124:1997;4999-5011.
    • (1997) Development , vol.124 , pp. 4999-5011
    • Erickson, S.L.1    O'Shea, K.S.2    Ghaboosi, N.3    Loverro, L.4    Frantz, G.5    Bauer, M.6    Lu, L.H.7    Moore, M.W.8
  • 18
    • 0035871159 scopus 로고    scopus 로고
    • Dose-dense sequential chemotherapy with epirubicin and paclitaxel versus the combination, as first-line chemotherapy, in advanced breast cancer: A randomized study conducted by the Hellenic Cooperative Oncology Group
    • Fountzilas G., Papadimitriou C., Dafni U., Bafaloukos D., Skarlos D., Moulopoulos L.A., Razis E., Kalofonos H.P., Aravantinos G., Briassoulis E.et al. Dose-dense sequential chemotherapy with epirubicin and paclitaxel versus the combination, as first-line chemotherapy, in advanced breast cancer. a randomized study conducted by the Hellenic Cooperative Oncology Group J. Clin. Oncol. 19:2001;2232-2239.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2232-2239
    • Fountzilas, G.1    Papadimitriou, C.2    Dafni, U.3    Bafaloukos, D.4    Skarlos, D.5    Moulopoulos, L.A.6    Razis, E.7    Kalofonos, H.P.8    Aravantinos, G.9    Briassoulis, E.10
  • 22
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • Gassmann M., Casagranda F., Orloff D., Simon H., Lai C., Klein R., Lemke G. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 378:1995;390-394.
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orloff, D.3    Simon, H.4    Lai, C.5    Klein, R.6    Lemke, G.7
  • 23
    • 0030977565 scopus 로고    scopus 로고
    • Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development
    • Hansen L.A., Alexander N., Hogan M.E., Sundberg J.P., Dlugosz A., Threadgill D.W., Magnuson T., Yuspa S.H. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am. J. Pathol. 150:1997;1959-1975.
    • (1997) Am. J. Pathol. , vol.150 , pp. 1959-1975
    • Hansen, L.A.1    Alexander, N.2    Hogan, M.E.3    Sundberg, J.P.4    Dlugosz, A.5    Threadgill, D.W.6    Magnuson, T.7    Yuspa, S.H.8
  • 24
    • 0031127628 scopus 로고    scopus 로고
    • A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation
    • Helmrath M.A., Erwin C.R., Warner M.D. A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation. J. Surg. Res. 69:1997;76-80.
    • (1997) J. Surg. Res. , vol.69 , pp. 76-80
    • Helmrath, M.A.1    Erwin, C.R.2    Warner, M.D.3
  • 25
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab prolongs survival in first-line colorectal cancer: Results of a phase III trial of bevacizumab in combination with bolus IFL as first-line therapy in subjects with metastatic CRC
    • Hurwitz, H.I., Fehrenbacher, L., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Griffing, S., Novotny, W.F., Holmgren, E., and Kabbinavar, F. (2003). Bevacizumab prolongs survival in first-line colorectal cancer: Results of a phase III trial of bevacizumab in combination with bolus IFL as first-line therapy in subjects with metastatic CRC. Presented at ASCO Proceedings.
    • (2003) ASCO Proceedings
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Cartwright, T.3    Hainsworth, J.4    Heim, W.5    Berlin, J.6    Griffing, S.7    Novotny, W.F.8    Holmgren, E.9    Kabbinavar, F.10
  • 26
    • 0037507267 scopus 로고    scopus 로고
    • Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling
    • Jackson L.F., Qiu T.H., Sunnarborg S.W., Chang A., Zhang C., Patterson C., Lee D.C. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 22:2003;2704-2716.
    • (2003) EMBO J. , vol.22 , pp. 2704-2716
    • Jackson, L.F.1    Qiu, T.H.2    Sunnarborg, S.W.3    Chang, A.4    Zhang, C.5    Patterson, C.6    Lee, D.C.7
  • 27
    • 2942657615 scopus 로고    scopus 로고
    • A Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel to carboplatin and paclitaxel alone in previously untreated locally advanced (IIIB) or metastatic non-small cell lung cancer
    • Johnson D.H., Fehrenbacher L., Novotny W.F., Herbst R.S., Nemunaitis J., Jablons D.M., Langer C.L., Devore R.F., Gaudreault J., Damico L.A.et al. A Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel to carboplatin and paclitaxel alone in previously untreated locally advanced (IIIB) or metastatic non-small cell lung cancer. J. Clin. Oncol. in press:2004.
    • (2004) J. Clin. Oncol.
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.5    Jablons, D.M.6    Langer, C.L.7    Devore, R.F.8    Gaudreault, J.9    Damico, L.A.10
  • 28
    • 0030873185 scopus 로고    scopus 로고
    • Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor
    • Joshi V., Ray G.S., Goldenring J.R. Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor. Dig. Dis. Sci. 42:1997;1194-1198.
    • (1997) Dig. Dis. Sci. , vol.42 , pp. 1194-1198
    • Joshi, V.1    Ray, G.S.2    Goldenring, J.R.3
  • 29
    • 1442329033 scopus 로고    scopus 로고
    • Acute lung injury in lung cancer patients treated with ZD1839 and bleomycin-induced pulmonary fibrosis in mice
    • Kanemura T., Suzuki H., Aoshiba K., Yokohori N., Nagai A. Acute lung injury in lung cancer patients treated with ZD1839 and bleomycin-induced pulmonary fibrosis in mice. Proc. Am. Soc. Clin. Oncol. 22:2003;652.
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 652
    • Kanemura, T.1    Suzuki, H.2    Aoshiba, K.3    Yokohori, N.4    Nagai, A.5
  • 30
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor Erbb2 in neural and cardiac development
    • Lee K.F., Simon H., Chen H., Bates B., Hung M.C., Hauser C. Requirement for neuregulin receptor Erbb2 in neural and cardiac development. Nature. 378:1995;394-398.
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 31
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • Leveen P., Larsson J., Ehinger M., Cilio C.M., Sundler M., Sjostrand L.J., Holmdahl R., Karlsson S. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 100:2002;560-568.
    • (2002) Blood , vol.100 , pp. 560-568
    • Leveen, P.1    Larsson, J.2    Ehinger, M.3    Cilio, C.M.4    Sundler, M.5    Sjostrand, L.J.6    Holmdahl, R.7    Karlsson, S.8
  • 32
    • 0345708717 scopus 로고
    • The occurrence of a dominant spotting mutation in the house mouse
    • Little C.C., Cloudman A.M. The occurrence of a dominant spotting mutation in the house mouse. Proc. Natl. Acad. Sci. USA. 23:1937;535-537.
    • (1937) Proc. Natl. Acad. Sci. USA , vol.23 , pp. 535-537
    • Little, C.C.1    Cloudman, A.M.2
  • 35
    • 0027315183 scopus 로고
    • Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
    • Mann G.B., Fowler K.J., Gabriel A., Nice E.C., Williams R.L., Dunn A.R. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell. 73:1993;249-261.
    • (1993) Cell , vol.73 , pp. 249-261
    • Mann, G.B.1    Fowler, K.J.2    Gabriel, A.3    Nice, E.C.4    Williams, R.L.5    Dunn, A.R.6
  • 36
    • 0142240380 scopus 로고    scopus 로고
    • Preventing toxicity with a gene test
    • Marshall E. Preventing toxicity with a gene test. Science. 302:2003;588-590.
    • (2003) Science , vol.302 , pp. 588-590
    • Marshall, E.1
  • 37
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 376:1995;337-341.
    • (1995) Nature , vol.376 , pp. 337-341
    • Miettinen, P.J.1    Berger, J.E.2    Meneses, J.3    Phung, Y.4    Pedersen, R.A.5    Werb, Z.6    Derynck, R.7
  • 38
    • 0242694530 scopus 로고    scopus 로고
    • Current status of gene therapy for lung cancer and head and neck cancer
    • Moon C., Oh Y., Roth J.A. Current status of gene therapy for lung cancer and head and neck cancer. Clin. Cancer Res. 9:2003;5055-5067.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5055-5067
    • Moon, C.1    Oh, Y.2    Roth, J.A.3
  • 40
    • 0142241307 scopus 로고    scopus 로고
    • Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans
    • Moss K.G., Toner G.C., Cherrington J.M., Mendel D.B., Laird A.D. Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans. J. Pharmacol. Exp. Ther. 307:2003;476-480.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 476-480
    • Moss, K.G.1    Toner, G.C.2    Cherrington, J.M.3    Mendel, D.B.4    Laird, A.D.5
  • 45
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J., Miller A.L., Perez-Mancera P.A., Wysocki J.M., Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:2003;223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 46
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • Saltz L., Kies M., Abbruzzese J.L., Azarnia N., Needle M. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc. Am. Soc. Clin. Oncol. 22:2003;204.
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 204
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3    Azarnia, N.4    Needle, M.5
  • 48
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M., Wagner E.F. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 269:1995;234-238.
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 50
    • 0028059309 scopus 로고
    • Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    • Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 8:1994;1888-1896.
    • (1994) Genes Dev. , vol.8 , pp. 1888-1896
    • Soriano, P.1
  • 51
    • 0030808324 scopus 로고    scopus 로고
    • The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
    • Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development. 124:1997;2691-2700.
    • (1997) Development , vol.124 , pp. 2691-2700
    • Soriano, P.1
  • 52
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P., Montgomery C., Geske R., Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 64:1991;693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 53
    • 0041887251 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis
    • Suzuki H., Aoshiba K., Yokohori N., Nagai A. Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Cancer Res. 63:2003;5054-5059.
    • (2003) Cancer Res. , vol.63 , pp. 5054-5059
    • Suzuki, H.1    Aoshiba, K.2    Yokohori, N.3    Nagai, A.4
  • 54
    • 0038204479 scopus 로고    scopus 로고
    • Clinical efficacy and toxicity of gefitinib in patients with lung cancer
    • Teramoto S., Yamamoto H., Ouchi Y. Clinical efficacy and toxicity of gefitinib in patients with lung cancer. Lancet. 361:2003;1992-1993.
    • (2003) Lancet , vol.361 , pp. 1992-1993
    • Teramoto, S.1    Yamamoto, H.2    Ouchi, Y.3
  • 58
    • 0034950574 scopus 로고    scopus 로고
    • Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha
    • Troyer K.L., Luetteke N.C., Saxon M.L., Qiu T.H., Xian C.J., Lee D.C. Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha. Gastroenterology. 121:2001;68-78.
    • (2001) Gastroenterology , vol.121 , pp. 68-78
    • Troyer, K.L.1    Luetteke, N.C.2    Saxon, M.L.3    Qiu, T.H.4    Xian, C.J.5    Lee, D.C.6
  • 59
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
    • Tybulewicz V.L., Crawford C.E., Jackson P.K., Bronson R.T., Mulligan R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 65:1991;1153-1163.
    • (1991) Cell , vol.65 , pp. 1153-1163
    • Tybulewicz, V.L.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 62
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs-will they model the next 100?
    • Zambrowicz B.P., Sands A.T. Knockouts model the 100 best-selling drugs-will they model the next 100? Nat. Rev. Drug Discov. 2:2003;38-51.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.