Cofilin takes the lead

Journal of Cell Science

Volumn 118, Issue 1, 2005, Pages 19-26

  DesMarais, Vera ^a   Ghosh, Mousumi ^a   Eddy, Robert ^a   Condeelis, John ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Arp2 3 complex; Chemotaxis; Stimulated protrusion model

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; CALCINEURIN; COFILIN; F ACTIN; G ACTIN; GELSOLIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROFILIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TROPOMYOSIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CARCINOMA CELL; CELL MIGRATION; CELL MOTILITY; CELL STIMULATION; DEPOLYMERIZATION; ENZYME ACTIVITY; HUMAN; MUSCLE CELL; NEUROBLASTOMA CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; CELL MOVEMENT; CHEMOTAXIS; COMPUTER SIMULATION; CYTOSKELETAL PROTEINS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION;

EID: 14044277430     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01631     Document Type: Article

References (88)

1. Agnew, B. J., Minamide, L. S. and Bamburg, J. R. (1995). Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site. J. Biol. Chem. 270, 17582-17587.
2. Aizawa, H., Katadae, M., Maruya, M., Sameshima, M., Murakami-Murofushi, K. and Yahara, I. (1999). Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin. Genes Cells 4, 311-324.
3. Allen, P. G. (2003). Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles. Nat. Cell Biol. 5 972-979.
4. Amann, K. J. and Pollard, T. D. (2001). Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy. Proc. Natl. Acad. Sci. USA 98, 15009-15013.
5. Ambach, A., Saunus, J., Konstandin, M., Wesselborg, S., Meuer, S. C. and Samstag, Y. (2000). The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes. Eur. J. Immunol. 30, 3422-3431.
6. Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O. and Caroni, P (1998). Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393, 805-809.
7. Azuma, T., Witke, W., Stossel, T. P., Hartwig, J. H. and Kwiatkowski, D. J. (1998). Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 17, 1362-1370.
8. Bailly, M., Macaluso, F., Cammer, M., Chan, A., Segall, J. E. and Condeelis, J. S. (1999). Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. J. Cell Biol. 145, 331-345.
9. Bailly, M., Ichetovkin, I., Grant, W., Zebda, N., Machesky, L. M., Segall, J. E. and Condeelis, J. (2001). The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension. Curr. Biol. 11, 620-625.
10. Balcer, H. I., Goodman, A. L., Rodal, A. A., Smith, E., Kugler, J., Heuser, J. E. and Goode, B. L. (2003). Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1. Curr. Biol. 13, 2159-2169.
11. Bamburg, J. R. (1999). Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu. Rev. Cell Dev. Biol. 15, 185-230.
12. Bernstein, B. W. and Bamburg, J. R. (1982). Tropomyosin binding to F-actin protects the F-actin from disassembly by brain actin-depolymerizing factor (ADF). Cell Motil. 2, 1-8.
13. Bernstein, B. W., Painter, W. B., Chen, H., Minamide, L. S., Abe, H. and Bamburg, J. R. (2000). Intracellular pH modulation of ADF/cofilin proteins. Cell Motil. Cytoskeleton 47, 319-336.
14. Bertling, E., Hotulainen, P., Mattila, P. K., Matilainen, T., Salminen, M. and Lappalainen, P. (2004). Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol. Biol. Cell 15, 2324-2334.
15. Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J. B., Kaiser, D. A. and Pollard, T. D. (2000). Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature 404, 1007-1011.
16. Blanchoin, L., Pollard, T. D. and Hitchcock-DeGregori, S. E. (2001). Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin. Curr. Biol. 11, 1300-1304.
17. Bryce, N. S., Schevzov, G., Ferguson, V., Percival, J. M., Lin, J. J., Matsumura, F., Bamburg, J. R., Jeffrey, P. L., Hardeman, E. C., Gunning, P. et al. (2003). Specification of actin filament function and molecular composition by tropomyosin isoforms. Mol. Biol. Cell 14, 1002-1016.
18. Carlier, M. F., Laurent, V., Santolini, J., Melki, R., Didry, D., Xia, G. X., Hong, Y., Chua, N. H. and Pantaloni, D. (1997 . Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J. Cell Biol. 136 1307-1322.
19. Chan, A. Y., Raft, S., Bailly, M., Wyckoff, J. B., Segall, J. E. and Condeelis, J. S. (1998). EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells. J. Cell Sci. 111, 199-211.
20. Chan, A. Y., Bailly, M., Zebda, N., Segall, J. E. and Condeelis, J. S. (2000). Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. J. Cell Biol. 148, 531-542.
21. 3 accumulation and have unique roles during chemotaxis. Mol. Biol. Cell 14, 5028-5037.
22. Chou, J., Stolz, D. B., Burke, N. A., Watkins, S. C. and Wells, A. (2002). Distribution of gelsolin and pbosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility. Int. J. Biochem. Cell Biol. 34, 776-790.
23. Condeelis, J. (2001). How is actin polymerization nucleated in vivo? Trends Cell Biol. 11, 288-293.
24. Condeelis, J. S., Wyckoff, J. B., Bailly, M., Pestell, R., Lawrence, D., Backer, J. and Segall, J. E. (2001). Lamellipodia in invasion. Semin. Cancer Biol. 11, 119-128.
25. Cooper, J. A. (2002). Actin dynamics: tropomyosin provides stability. Curr. Biol. 12, R523-R525.
26. Cox, D., Condeelis, J., Wessels, D., Soll, D., Kern, H. and Knecht, D. A. (1992). Targeted disruption of the ABP-120 gene leads to cells with altered motility. J. Cell Biol. 116, 943-955.
27. Cramer, L. P. (1999). Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr. Biol. 9, 1095-1105.
28. Dan, C., Kelly, A., Bernard, O. and Minden, A. (2001). Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J. Biol. Chem. 276, 32115-32121.
29. Dawe, H. R., Minamide, L. S., Bamburg, J. R. and Cramer, L. P. (2003). ADF/cofilin controls cell polarity during fibroblast migration. Curr. Biol. 13, 252-257.
30. DesMarais, V., Ichetovkin, I., Condeelis, J. and Hitchcock-DeGregori, S. E. (2002). Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J. Cell Sci. 115, 4649-4660.
31. DesMarais, V., Macaluso, F., Condeelis, J. and Bailly, M. (2004). Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. J. Cell Sci. 117, 3499-3510.
32. dos Remedios, C. G., Chhabra, D., Kekic, M., Dedova, I. V., Tsubakibara, M., Berry, D. A. and Nosworthy, N. J. (2003). Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol. Rev. 83, 433-473.
33. Du, J. and Frieden, C. (1998). Kinetic studies on the effect of yeast cofilin on yeast actin polymerization. Biochemistry 37, 13276-13284.
34. Eddy, R. J., Han, J. and Condeelis, J. S. (1997). Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium. J. Cell Biol. 139, 1243-1253.
35. Edmonds, B. T., Wyckoff, J., Yeung, Y. G., Wang, Y., Stanley, E. R., Jones, J., Segall, J. and Condeelis, J. (1996). Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. J. Cell Sci. 109, 2705-2714.
36. Endo, M., Ohashi, K., Sasaki, Y., Goshima, Y., Niwa, R., Uemura, T. and Mizuno, K. (2003). Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. J. Neurosci. 23, 2527-2537.
37. Evangelista, M., Zigmond, S. and Boone, C. (2003). Formins: signaling effectors for assembly and polarization of actin filaments. J. Cell Sci. 116, 2603-2611.
38. Falet, H., Barkalow, K. L., Pivniouk, V. I., Barnes, M. J., Geha, R. S. and Hartwig, J. H. (2000). Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood 96, 3786-3792.
39. Falet, H., Hoffmeister, K. M., Neujahr, R., Italiano, J. E., Jr, Stossel, T. P., Southwick, F. S. and Hartwig, J. H. (2002). Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc. Natl. Acad. Sci. USA 99, 16782-16787.
40. Funamoto, S., Meili, R., Lee, S., Parry, L. and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
41. Ghosh, M., Song, X., Mouneimne, G., Sidani, M., Lawrence, D. S. and Condeelis, J. S. (2004). Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304, 743-746.
42. Gohla, A. and Bokoch, G. M. (2002). 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr. Biol. 12, 1704-1710.
43. Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G. and Pollard, T. D. (1991). Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. Science 251 1231-1233.
44. Goldschmidt-Clermont, P. J., Furman, M. I., Wachsstock, D., Safer, D., Nachmias, V. T. and Pollard, T. D. (1992). The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. Mol. Biol. Cell 3, 1015-1024.
45. Hall, A. L., Warren, V., Dharmawardhane, S. and Condeelis, J. (1989). Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation. J. Cell Biol. 109, 2207-2213.
46. Hammell, R. L. and Hitchcock-DeGregori, S. E. (1996). Mapping the functional domains within the carboxyl terminus of alpha-tropomyosin encoded by the alternatively spliced ninth exon. J. Biol. Chem. 271, 4236-4242.
47. Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A. and Stossel, T. P. (1995). Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.
48. Hawkins, M., Pope, B., Maciver, S. K. and Weeds, A. G. (1993). Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry 32, 9985-9993.
49. Higgs, H. N. and Pollard, T. D. (2001). Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Annu. Rev. Biochem. 70, 649-676.
50. Ichetovkin, I., Han, J., Pang, K. M., Knecht, D. A. and Condeelis, J. S. (2000). Actin filaments are severed by both native and recombinant Dictyostelium cofilin but to different extents. Cell Motil. Cytoskeleton 45, 293-306.
51. Ichetovkin, I., Grant, W. and Condeelis, J. (2002). Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr. Biol. 12, 79-84.
52. Iijima, M. and Devreotes, P. (2002). Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610.
53. Kanamori, T., Hayakawa, T., Suzuki, M. and Titani, K. (1995). Identification of two 17-kDa rat parotid gland phosphoproteins, subjects for dephosphorylation upon beta-adrenergic stimulation, as destrin- and cofilin-like proteins. J. Biol. Chem. 270, 8061-8067.
54. Kassis, J., Moellinger, J., Lo, H., Greenberg, N. M., Kim, H. G. and Wells, A. (1999). A role for phospholipase C-gamma-mediated signaling in tumor cell invasion. Clin. Cancer Res. 5, 2251-2260.
55. Lappalainen, P. and Drubin, D. G. (1997). Cofilin promotes rapid actin filament turnover in vivo. Nature 388, 78-82.
56. Loisel, T. P., Boujemaa, R., Pantaloni, D. and Cartier, M. F. (1999). Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature 401, 613-616.
57. Maciver, S. K., Zot, H. G. and Pollard, T. D. (1991). Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J. Cell Biol. 115, 1611-1620.
58. Maciver, S. K., Pope, B. J., Whytock, S. and Weeds, A. G. (1998). The effect of two actin depolymerizing factors (ADF/cofilins) on actin filament turnover: pH sensitivity of F-actin binding by human ADF, but not of Acanthamoeba actophorin. Eur. J. Biochem. 256 388-397.
59. McGough, A., Pope, B., Chiu, W. and Weeds, A. (1997). Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function. J. Cell Biol. 138, 771-781.
60. Meberg, P. J., Ono, S., Minamide, L. S., Takahashi, M. and Bamburg, J. R. (1998). Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension. Cell Motil. Cytoskeleton 39, 172-190.
61. Moriyama, K. and Yahara, I. (2002). Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J. Cell Sci. 115, 1591-1601.
62. Moriyama, K., Iida, K. and Yahara, I. (1996). Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1, 73-86.
63. Mouneimne, G., Soon, L., DesMarais, V., Sidani, M., Song, X., Yip, S. C., Ghosh, M., Eddy, R., Backer, J. M. and Condeelis, J. (2004). Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J. Cell Biol. 166 697-708.
64. Mullins, R. D., Heuser, J. A. and Pollard, T. D. (1998). The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc. Natl. Acad. Sci. USA 95, 6181-6186.
65. Niwa, R., Nagata-Ohashi, K., Takeichi, M., Mizuno, K. and Uemura, T. (2002). Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell 108, 233-246.
66. Ojala, P. J., Paavilainen, V. and Lappalainen, P. (2001). Identification of yeast cofilin residues specific for actin monomer and PIP2 binding. Biochemistry 40, 15562-15569.
67. Okada, K., Takano-Ohmuro, H., Obinata, T. and Abe, H. (1996). Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood. Exp. Cell Res. 227, 116-122.
68. Okada, K., Obinata, T. and Abe, H. (1999). XAIP1: a Xenopus homologue of yeast actin interacting protein 1 (AIP1), which induces disassembly of actin filaments cooperatively with ADF /cofilin family proteins. J. Cell Sci. 112, 1553-1565.
69. Ono, S. (2003). Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1, new blades for twisted filaments. Biochemistry 42, 13363-13370.
70. Ono, S. and Ono, K. (2002). Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics. J. Cell Biol. 156 1065-1076.
71. Pantaloni, D., Boujemaa, R., Didry, D., Gounon, P. and Carlier, M. F. (2000). The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nat. Cell Biol. 2, 385-391.
72. Pollard, T. D. and Borisy, G. G. (2003). Cellular motility driven by assembly and disassembly of actin filaments. Cell 113, 549.
73. Pollard, T. D., Blanchoin, L. and Mullins, R. D. (2000). Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu. Rev. Biophys. Biomol. Struct. 29, 545-576.
74. Pruyne, D., Evangelista, M., Yang, C., Bi, E., Zigmond, S., Bretscher, A. and Boone, C. (2002). Role of formins in actin assembly: nucleation and barbed-end association. Science 297, 612-615.
75. Rodal, A. A., Tetreault, J. W., Lappalainen, P., Drubin, D. G. and Amberg, D. C. (1999). Aip1p interacts with cofilin to disassemble actin filaments. J. Cell Biol. 145, 1251-1264.
76. Rosok, O., Pedeutour, F., Ree, A. H. and Aasheim, H. C. (1999). Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Genomics 61, 44-54.
77. Schafer, D. A., Welch, M. D., Machesky, L. M., Bridgman, P. C., Meyer, S. M. and Cooper, J. A. (1998). Visualization and molecular analysis of actin assembly in living cells. J. Cell Biol. 143, 1919-1930.
78. Sun, H. Q., Yamamoto, M., Mejillano, M. and Yin, H. L. (1999). Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. 274, 33179-33182.
79. Suzuki, K., Yamaguchi, T., Tanaka, T., Kawanishi, T., Nishimaki-Mogami, T., Yamamoto, K., Tsuji, T., Irimura, T., Hayakawa, T. and Takahashi, A. (1995). Activation induces dephosphorylation of cofilin and its translocation to plasma membranes in neutrophil-like differentiated HL-60 cells. J. Biol. Chem. 270, 19551-19556.
80. Svitkina, T. M. and Borisy, G. G. (1999). Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J. Cell Biol. 145, 1009-1026.
81. Toshima, J., Toshima, J. Y., Amano, T., Yang, N., Narumiya, S. and Mizuno, K. (2001). Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol. Biol. Cell 12, 1131-1145.
82. Welch, M. D. and Mullins, R. D. (2002). Cellular control of actin nucleation. Annu. Rev. Cell Dev. Biol. 18, 247-288.
83. Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E. and Mizuno, K. (1998). Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393, 809-812.
84. Yonezawa, N., Nishida, E. and Sakai, H. (1985). pH control of actin polymerization by cofilin. J. Biol. Chem. 260 14410-14412.
85. Yonezawa, N., Nishida, E., Iida, K., Yahara, I. and Sakai, H. (1990). Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. J. Biol. Chem. 265, 8382-8386.
86. Yonezawa, N., Homma, Y., Yahara, I., Sakai, H. and Nishida, E. (1991). A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilin. J. Biol. Chem. 266, 17218-17221.
87. Zebda, N., Bernard, O., Bailly, M., Welti, S., Lawrence, D. S. and Condeelis, J. S. (2000). Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension. J. Cell Biol. 151, 1119-1128.
88. Zhan, Q., Bamburg, J. R. and Badwey, J. A. (2003). Products of phosphoinositide specific phospholipase C can trigger dephosphorylation of cofilin in chemoattractant stimulated neutrophils. Cell Motil. Cytoskeleton 54, 1-15.