Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin

Current Biology

Volumn 11, Issue 16, 2001, Pages 1300-1304

  Schottler, F ^a   Fabiato, H ^a   Leland, J M ^a   Chang, L Y ^a   Lotfi, P ^a   Getachew, F ^a   Lee, K S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; VESPIDAE;

EID: 0035928737     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00395-5     Document Type: Article

References (40)

1. Actin filament organization in the fish keratocyte lamellipodium
2. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation
3. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
4. Actin machinery: Pushing the envelope
5. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
6. Tropomyosin binding to F-actin protects the F-actin from disassembly by brain actin-depolymerizing factor (ADF)
7. Tropomyosin prevents depolymerization of actin filaments from the pointed end
8. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
9. Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins
10. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
11. Activation of Arp2/3 complex-mediated actin polymerization by cortactin
12. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation
13. Tropomyosin isoforms in nonmuscle cells
14. Differential localization of tropomyosin isoforms in cultured nonmuscle cells
15. Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: Evidence for distinct microfilament populations
16. Restricted expression of the actin-regulatory protein, tropomyosin, defines distinct boundaries, evaginating neuroepithelium, and choroid plexus forerunners during early CNS development
17. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins
18. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
19. Kinetic analysis of actin assembly suggests that tropomyosin inhibits spontaneous fragmentation of actin filaments
20. Two general classes of cytoplasmic actin filaments in tissue culture cells: The role of tropomyosin
21. Tropomyosin inhibits the rate of actin polymerization by stabilizing actin filaments
22. Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization
23. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
24. Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks
25. Mechanism of interaction of Acanthamoeba actophorin (ADF/Cofilin) with actin filaments
26. Rate of binding of tropomyosin to actin filaments
27. Rate and mechanism of the assembly of tropomyosin with actin filaments
28. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
29. The ends of tropomyosin are major determinants of actin affinity and myosin subfragment 1-induced binding to F-actin in the open state
30. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments
31. The muscle thin filament as a classical cooperative/allosteric regulatory system
32. Tropomyosin isoforms in chicken embryo fibroblasts: Purification, characterization, and changes in Rous sarcoma virus-transformed cells
33. Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments
34. The Arp2/3 complex branches filament barbed ends: Functional antagonism with capping proteins
35. The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin
36. Identification of a factor in conventional muscle actin preparations which inhibits actin filament self-association
37. Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin
38. Polymerization of ADP-actin
39. Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters
40. Tropomyosin lysine reactivities and relationship to coiled-coil structure