The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3422-3431

  Ambach, Andreas ^a   Saunus, Jochen ^a   Konstandin, Mathias ^a   Wesselborg, Sebastian ^a   Meuer, Stefan C ^a   Samstag, Yvonne ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Co stimulation; Cofilin; Immunosuppression; Phosphatase; T cell activation

Indexed keywords

ACTIN BINDING PROTEIN; CD2 ANTIGEN; CD28 ANTIGEN; COFILIN; CYCLOSPORIN A; DEXAMETHASONE; LEFLUNOMIDE; LIM PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MYCOPHENOLIC ACID; PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; TACROLIMUS;

ACTIN FILAMENT; ARTICLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPHOSPHORYLATION; DEPOLYMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ACTIN DEPOLYMERIZING FACTORS; CYCLOSPORINE; DEXAMETHASONE; HUMANS; ISOXAZOLES; MICROFILAMENT PROTEINS; MYCOPHENOLIC ACID; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; SIROLIMUS; T-LYMPHOCYTES; TACROLIMUS;

EID: 0034536444     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2000012)30:12<3422::AID-IMMU3422>3.0.CO;2-J     Document Type: Article

References (47)

1. Tolerance of T-cell clones is associated with membrane antigen changes
2. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
3. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
4. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
5. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
6. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
7. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
8. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response
9. A serine phosphatase is involved in CD2-mediated activation of human T lymphocytes and natural killer cells
10. Dephosphorylation of pp19: A common second signal for human T cell activation mediated through different accessory molecules
11. Costimulatory signals for human T cell activation induce nuclear translocation of pp19/cofilin
12. Cofilin: A missing link between T cell costimulation and rearrangement of the actin cytoskeleton
13. Inhibition of constitutive serine phosphatase activity in T lymphoma cells results in phosphorylation of pp19/cofilin and induces apoptosis
14. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin
15. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin
16. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
17. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
18. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases
19. The association of type 1, type 2A and type 2B phosphatases with the human T lymphocyte plasma membrane
20. Identification of calcineurin as key signalling enzyme in T-lymphocyte activation
21. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
22. Purification and properties of phosphoprotein phosphatases with different substrate and divalent cation specificities from canine heart
23. PPX, a novel protein serine/threonine phosphatase localized to centrosomes
24. The structure, role, and regulation of type 1 protein phosphatases
25. Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
26. The influence of cyclosporine A on the alternative pathways of human T cell activation in vitro
27. The B7 and CD28 receptor families
28. Calcineurin is a common target of cyclophilin-Cyclosporin A and FKBP-FK506 complexes
29. In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443
30. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
31. Leflunomide, a novel immunosuppressive agent. The mechanism of inhibition of T cell proliferation
32. Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes
33. Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A
34. Alternative pathway of T cell activation: A functional role for the 50kD T11 sheep erythrocyte receptor protein
35. The role of the CD28 receptor during T cell responses to antigen
36. Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-Mr actin-binding and depolymerizing protein
37. Cofilin is an essential component of the yeast cortical cytoskeleton
38. Xenopus laevis actin-depolymerizing factor/cofilin: A phosphorylation- regulated protein essential for development
39. Selective assay of monomeric and filamentous actin in cell extracts, using inhibition of desoxyribonuclease I
40. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death)
41. Dephosphorylation of cofilin accompanies heat shock-induced nuclear accumulation of cofilin
42. Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2 GTPase
43. Cyclosporin A-resistant transactivation of the IL-2 promotor requires activity of okadaic acid-sensitive serine/threonine phosphatases
44. Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells
45. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
46. Activation of human T lymphocytes: Differential effects of CD3- and CD8-mediated signals
47. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas