Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells

Journal of Immunology

Volumn 174, Issue 5, 2005, Pages 2680-2686

  Liu, Yan Chao ^a,b   Battaglia, Manuela ^a,c   Lee, Ho Seon ^a,d   Sun, Qi Hong ^a,b   Aster, Richard H ^a   Visentin, Gian Paolo ^a,b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; AUTOANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; THROMBOCYTE FACTOR 4;

ARTICLE; CLONAL ANERGY; COCULTURE; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA;

EID: 14044273650     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2680     Document Type: Article

References (44)

1. Shevach, E. M. 2000. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18:423.
2. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
3. + T cells. Adv. Immunol. 81:331.
4. Levings, M. K., R. Bacchetta, U. Schulz, and M. G. Roncarolo. 2002. The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 129:263.
5. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
6. + regulatory T cells and infectious tolerance. Transplantation 77:S23.
7. high regulatory cells in human peripheral blood. J. Immunol. 167:1245.
8. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295.
9. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:237.
10. Battaglia, M., B. R. Blazar, and M. G. Roncarolo. 2002. The puzzling world of murine T regulatory cells. Microbes Infect. 4:559.
11. Groux, H., and F. Powrie. 1999. Regulatory T cells and inflammatory bowel disease. Immunol. Today 20:442.
12. - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
13. Luster, A. D. 1998. Chemokines: chemotactic cytokines that mediate inflammation. N. Engl. J Med. 338:436.
14. Strieter, R. M., P. J. Polverini, S. L. Kunkel, D. A. Arenberg, M. D. Burdick, J. Kasper, J. Dzuiba, J. Van Damme, A. Walz, D. Marriott, et al. 1995. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270:27348.
15. Broxmeyer, H. E., B. Sherry, S. Cooper, L. Lu, R. Maze, M. P. Beckmann, A. Cerami, and P. Ralph. 1993. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells: interacting effects involving suppression, synergistic suppression, and blocking of suppression. J. Immunol. 150:3448.
16. Fleischer, J., E. Grage-Griebenow, B. Kasper, H. Heine, M. Ernst, E. Brandt, H. D. Flad, and F. Petersen. 2002. Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells. J. Immunol. 169:770.
17. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196:1335.
18. + regulatory T cells. Semin. Immunol. 16:89.
19. Poncz, M., S. Surrey, P. LaRocco, M. J. Weiss, E. F. Rappaport, T. M. Conway, and E. Schwartz. 1987. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. Blood 69:219.
20. Visentin, G. P., S. E. Ford, J. P. Scott, and R. H. Aster. 1994. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J. Clin. Invest. 93:81.
21. Lyons, A. B. 2000. Analysing cell division in vivo and in vitro using flow Cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243:147.
22. Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin. Invest. 100:3173.
23. + cells: a naturally occurring population of regulatory T cells. Blood 98:2736.
24. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285.
25. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
26. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
27. - T cells. J. Leukocyte Biol. 75:785.
28. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
29. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
30. Lasagni, L., M. Francalanci, F. Annunziato, E. Lazzeri, S. Giannini, L. Cosmi, C. Sagrinati, B. Mazzinghi, C. Orlando, E. Maggi, et al. 2003. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 197:1537.
31. Stringer, S. E., and J. T. Gallagher. 1997. Specific binding of the chemokine platelet factor 4 to heparan sulfate. J. Biol. Chem. 272:20508.
32. Schlessinger, J., I. Lax, and M. Lemmon. 1995. Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell 83:357.
33. Kaneider, N. C., C. M. Reinisch, S. Dunzendorfer, J. Romisch, C. J. Wiedermann, and C. J. Wiederman. 2002. Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes. J. Cell. Sci. 115:227.
34. Zucker, M. B., and I. R. Katz. 1991. Platelet factor 4: production, structure, and physiologic and immunologic action. Proc. Soc. Exp. Biol. Med. 198:693.
35. O'Brien, J. R., M. D. Etherington, and M. Pashley. 1984. Intra-platelet platelet factor 4 (IP.PF4) and the heparin-mobilisable pool of PF4 in health and atherosclerosis. Thromb. Haemost. 51:354.
36. Marcum, J. A., and R. D. Rosenberg. 1989. Role of endothelial cell surface heparin-like polysaccharides. Ann. NY Acad. Sci. 556:81.
37. Taub, D. D., S. M. Turcovski-Corrales, M. L. Key, D. L. Longo, and W. J. Murphy. 1996. Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation' in vitro. J. Immunol. 156:2095.
38. Gentilini, G., N. E. Kirschbaum, J. A. Augustine, R. H. Aster, and G. P. Visentin. 1999. Inhibition of human umbilical vein endothelial cell proliferation by the CXC chemokine, platelet factor 4 (PF4), is associated with impaired downregulation of p21(Cip1/WAF1). Blood 93:25.
39. Petersen, F., L. Bock, H. D. Flad, and E. Brandt. 1999. Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8. Blood 94:4020.
40. Scheuerer, B., M. Ernst, I. Durrbaum-Landmann, J. Fleischer, E. Grage-Griebenow, E. Brandt, H. D. Flad, and F. Petersen. 2000. The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 95:1158.
41. Zucker, M. B. 1975. Effect of heparin on platelet function. Thromb. Diath. Haemorrh. 33:63.
42. Wan, S., J. L. LeClerc, and J. L. Vincent. 1997. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112:676.
43. Visentin, G. P., M. Malik, K. A. Cyganiak, and R. H. Aster. 1996. Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin:platelet factor 4 complexes. J. Lab. Clin. Med. 128:376.
44. Yamamoto, S., M. Koide, M. Matsuo, S. Suzuki, M. Ohtaka, S. Saika, and T. Matsuo. 1996. Heparin-induced thrombocytopenia in hemodialysis patients. Am. J. Kidney Dis. 28:82.