The effect of TGFbeta1 on the expression and phosphorylation of key cell-cycle regulators in malignant B cells

Medical Science Monitor

Volumn 10, Issue 12, 2004, Pages

  Tvrdík, Daniel ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cyclin dependent kinase; Cyclin dependent kinase inhibitor; Follicular lymphoma; Retinoblastoma tumor suppressor protein; Transforming growth factor beta1

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; PHOSPHOTRANSFERASE; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; SERINE; THREONINE; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; DECOMPOSITION; ENZYME INACTIVATION; ENZYME INHIBITION; FOLLICULAR LYMPHOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MITOSIS INHIBITION; NONHODGKIN LYMPHOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; PHOSPHORYLATION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 13944267911     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Zetterberg AH, Pettersson RF, Lindahl SG: Hartwell, Hunt and Nurse share the 2001 Nobel Prize in physiology or medicine. CDK and cyclin - molecular motors of cell cycle. Lakartidningen, 2001; 42: 4544-50
2. Sherr CJ: Mammalian G1 cyclins. Review Cell, 1993; 73: 1059-65
3. Bates S, Bonetta L, MacAllan D et al: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cydin-dependent kinases that associate with cyclin D1. Oncogene, 1994; 9: 71-79
4. Sporn MB, Roberts AB: TGF-beta: problems and prospects. Cell Regulation, 1990; 1: 875-82
5. Pokrovskaja K, Ehlin-Henriksson B, Bartkova J et al: Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines. Cell Growth Differ, 1996; 7: 1723-32
6. Jeffrey PD, Tong I, Pavletich NP: Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev, 2000; 14: 3115-25
7. Niculescu AB, Chen X, Smeets M et al: Effects of p21(Cip1/ Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol, 1998; 18: 629-43
8. Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev, 1995; 9: 1149-63
9. Grana X, Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases cdks, growth suppressor genes and cyclin-dependent kinase inhibitors CKIs. Oncogene, 1995; 11: 211-19
10. LaBaer J, Garrett MD, Stevenson LF et al: New functional activities for the p21 family of CDK inhibitors. Genes Dev, 1997; 7: 847-62
11. Welcker M, Lucas J, Strauss M, Bartek J: p21WAF1/CIP1 mutants deficient in inhibiting cyclin-dependent kinases (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells. Cancer Res, 1998; 22: 5053-56
12. Rozga J: Hepatocyte proliferation in health and in liver failure. Med Sci Monit, 2002; 8(2): RA32-RA38
13. Douglas RS, Capocasale RJ, Lamb RJ et al: Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. Blood, 1997; 89: 941-47
14. Bouchard C, Fridman WH, Cautes C: Effects of TGF-beta1 on cell cycle regulatory proteins in LPS-stimulated normal mouse B lymphocytes. J Immunol, 1997; 159: 4155-64
15. DeVisser KE, Kast WM: Effects of TGF-beta on the immune system: implications for cancer immunotherapy. Leukemia, 1999; 13: 1188-99
16. Zarkowska T, Mittnach S: Differential phosphorylation of Retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem, 1997; 19: 12738-46
17. LaThangue NB: DP and E2F proteins: components a heterodimeric transcription factor implicated in cell cycle control. Curr Opin Cell Biol, 1994; 6: 443-50
18. Paggi MG, Baldi A, Bonetto F, Giordano A: Retinoblastoma protein family in cell cycle and cancer: a review. J Cell Biochem, 1996; 62: 340-418
19. Geng Y, Eaton EN, Picon M et al: Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene, 1996; 12: 1173-80
20. Connell-Crowley L, Harper JW, Goodrich DW: Cyclin D1/Cdk4 regulates Retinoblastoma protein mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell, 1997; 8: 287-301
21. Nevins JR: Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ, 1998; 9: 585-93
22. Bartek J, Bartkova J, Lukas J: The retinoblastoma protein pathway in cell cycle control and cancer. Exp Cell Res, 1997; 237: 1-6
23. Canhoto AJ, Chestukhin A, Litovchick L, DeCaprio JA: Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells. Oncogene. 2000; 19: 5116-22
24. Niller H, Salamon D, Ilg K et al: The in vivo binding site for oncoprotein c-Myc in the promoter for Ebstein-Barr virus (EBV) encoding RNA (EBER) 1 suggests a specific role for EBV in lymphomagenesis. Med Sci Monit, 2003; 9(1): HY1-HY9
25. Chaouchi N, Arvanitakis L, Auffredou MT et al: Characterization of transforming growth factor-beta 1 induced apoptosis in normal human B cells and lymphoma B cell lines. Oncogene, 1995; 11: 1615-22
26. Kluin-Nelemans HC, Limpers J, Meerabux J et al: A new non-Hodgkin's B-cell line DoHH2 with a chromosomal translocation t(14;18) (q32;q21). Leukemia, 1991; 5: 221-24
27. Djaborkhel R, Tvrdik D, Eckschlager T et al: Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells. Exp Cell Res, 2000; 261:250-59
28. WAF1 in growth-arrested lymphoma cells. J Struct Biol, 2002; 140: 49-56
29. Arvanitakis L, Yaseen N, Sharma S: Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells. J Immunol, 1995; 55: 1047-56
30. Russo AA, Tong L, Lee JO et al: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 1998; 395: 237-43
31. Finke J, Fritzen R, Ternes P et al: Expression of bcl-2 in Burkitt's lymphoma cell lines: induction by latent Epstein-Barr virus genes. Blood, 1992; 80: 459-69
32. Sandhu C, Garbe J, Bhattacharya N et al: Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. Mol Cell Biol, 1997; 17: 2458-67
33. Jeffrey PD, Russo AA, Polya K et al: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature, 1995; 376: 313-20
34. Brotherton DH, Dhanaraj V, Wick S et al: Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature, 1998; 395: 244-50
35. Russo AA, Jeffrey PD, Patten AK et al: Crystal structure of the p27Kip1 cyclin-dependent-ldnase inhibitor bound to the cyclin A-Cdk2 complex. Nature, 1996; 382: 325-31
36. Diehl JA, Sherr CJ: Dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Mol Cell Biol, 1997; 7: 7362-74
37. Kamesaki H, Nishizawa K, Michaud GY et al: TGF-beta 1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells. J Immunol, 1998; 160: 770-77
38. Rank KB, Evans DB, Sharma SK: The N-terminal of cyclin-dependent kinase inhibitory proteins block the phosphorylation of cdk2/cyclin E by the CDK-activating kinase. Biochem Biophys Res Commun. 2000; 271: 469-73
39. Kaldis P, Russo AA, Chou H et al: Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Mol Biol Cell, 1998; 9: 2545-60
40. Valverius EM, Walker-Jones D, Bates SE et al: Production of and responsiveness to transforming growth factor-beta 1 in normal and oncogene-transformed human mammary epithelial cells. Cancer Res, 1989; 49: 6269-77
41. Yoshizumi M, Wang H, Hsieh CM et al: Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J Biol Chem, 1997; 272: 22259-64
42. Barlat I, Henglein B, Plet A et al: TGFbeta1 and cAMP attenuate cyclin A gene transcription via a camp response element through independent pathways. Oncogenes, 1995; 11: 1309-18
43. Shimizu M, Nomura Y, Suzuki H et al: Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. Exp Cell Res, 1998; 239: 93-103
44. Ginty DD, Bading H, Greenberg ME: Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science, 1993; 260: 238-41
45. Müller J, Tvrdík D, Dvořák R et al: Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes. Acta Histochem, 2000; 102: 369-80