Defensins and mucosal protection

Novartis Foundation Symposium

Volumn 263, Issue , 2004, Pages 71-77

  Mahida, Y R ^a   Cunliffe, R N ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN; DEFB4 PROTEIN, HUMAN; DEFENSIN; PEPTIDE;

ANIMAL; BIOSYNTHESIS; CHEMISTRY; EPITHELIUM CELL; HUMAN; INFLAMMATION; INTESTINE MUCOSA; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; REVIEW;

ALPHA-DEFENSINS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; DEFENSINS; EPITHELIAL CELLS; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; PEPTIDES;

EID: 13844307905     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (30)

1. Cunliffe RN, Kamal M, Rose FR, James PD, Mahida YR 2002 Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa. J Clin Pathol 55:298-304
2. Cunliffe RN, Mahida YR 2004 Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J Leukoc Biol 75:49-58
3. Cunliffe RN, Rose FR, Keyte J et al 2001 Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 48:176-185
4. Fahlgren A, Hammarstrom S, Danielsson A, Hammarstrom ML 2003 Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis. Clin Exp Immunol 131:90-101
5. Ghosh D, Porter E, Shen B et al 2002 Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol 3:583-590
6. Hall PA, Coates PJ, Ansari B, Hopwood D 1994 Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci 107:3569-3577
7. Harper PH, Lee EC, Kettlewell MG, Bennett MJ 1985 Role of the faecal stream in the maintenance of Crohn's colitis. Gut 26:279-284
8. Hooper LV, Midtvedt T, Gordon JI 2002 How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 22:283-307
9. Hooper LV, Stappenbeck TS, Hong CV, Gordon JI 2003 Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 4:269-273
10. Islam D, Bandholtz L, Nilsson J et al 2001 Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 7:180-185
11. Izadpanah A, Dwinell MB, Eckmann L, Varki NM, Kagnoff MF 2001 Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol 280:G710-G719
12. Kamal M, Wakelin D, Ouellete AJ, Smith A, Podolsky DK, Mahida YR 2001 Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice. Clin Exp Immunol 126:117-125
13. Konishi A, Shimizu S, Hirota J et al 2003 Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell 114:673-688
14. Kwon JH, Keates S, Bassani L, Mayer LF, Keates AC 2002 Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. Gut 51:818-826
15. Mahida YR, Makh S, Hyde S, Gray T, Borriello SP 1996 Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 38:337-347
16. O'Neil DA, Porter EM, Elewaut D et al 1999 Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 163:6718-6724
17. Ouellette AJ, Bevins CL 2001 Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis 7:43-50
18. Putsep K, Axelsson LG, Boman A et al 2000 Germ-free and colonized mice generate the same products from enteric prodefensins. J Biol Chem 275:40478-40482
19. Rose FR, Bailey K, Keyte JW, Chan WC, Greenwood D, Mahida YR 1998 Potential role of epithelial cell-derived histone H1 proteins in innate antimicrobial defense in the human gastrointestinal tract. Infect Immun 66:3255-3263
20. Salzman NH, Chou MM, de Jong H, Liu L, Porter EM, Patterson Y 2003a Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun 71:1109-1115
21. Salzman NH, Ghosh D, Huttner KM, Patterson Y, Bevins CL 2003b Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422:522-526
22. Savage DC 1977 Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31:107-133
23. Strober W, Fuss IJ, Blumberg RS 2002 The immunology of mucosal models of inflammation. Annu Rev Immunol 20:495-549
24. Takahashi A, Wada A, Ogushi K et al 2001 Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein. FEBS Lett 508:484-488
25. Tsutsumi-Ishii Y, Nagaoka I 2002 NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. J Leukoc Biol 71:154-162
26. Wehkamp J, Schwind B, Herrlinger KR et al 2002 Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins. Dig Dis Sci 47:1349-1355
27. Wilson CL, Ouellette AJ, Satchell DP et al 1999 Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286:113-117
28. Wu Z, Hoover DM, Yang D et al 2003 Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci USA 100:8880-8885
29. Yang D, Chertov O, Bykovskaia SN et al 1999 Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528
30. Zychlinsky A, Sansonetti P 1997 Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis. J Clin Invest 100:493-495