Insect olfactory receptors: Contributions of molecular biology to chemical ecology

Journal of Chemical Ecology

Volumn 30, Issue 12, 2004, Pages 2359-2397

  Jacquin Joly, Emmanuelle ^a   Merlin, Christine ^a  

^a CEMAGREF   (France)

Author keywords

Anopheles gambiae; Arrestin; Caenorhabditis elegans; CD36; Drosophila melanogaster; G protein coupled receptor; Guanylyl cyclase; Insects; Molecular biology; Olfaction; Olfactory receptors; SNMP

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN;

CHEMORECEPTION; OLFACTION;

AMINO ACID SEQUENCE; BIOINFORMATICS; COLEOPTERA; DATA ANALYSIS; DEVELOPMENTAL STAGE; DROSOPHILA; ECOLOGY; FLY; GENOME; GLOMERULUS; HEMOLYMPH; HYMENOPTERA; IMAGING; INSECT; INSECT DEVELOPMENT; INSECT GENETICS; LEPIDOPTERA; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PROTEIN DOMAIN; RECEPTOR GENE; REVIEW; SMELLING; SPECIES IDENTIFICATION; UNINDEXED SEQUENCE; VERTEBRATE;

ANIMALS; CHEMISTRY; ECOLOGY; GENOMICS; INSECTS; MOLECULAR BIOLOGY; MOLECULAR SEQUENCE DATA; OLFACTORY RECEPTOR NEURONS; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

ANOPHELES GAMBIAE; CAENORHABDITIS ELEGANS; COLEOPTERA; DIPTERA; DROSOPHILA MELANOGASTER; DROSOPHILIDAE; GLOMERULUS; HEXAPODA; HYMENOPTERA; INSECTA; LEPIDOPTERA; MELANOGASTER; VERTEBRATA;

EID: 13844254037     PISSN: 00980331     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10886-004-7941-3     Document Type: Review

References (128)

1. ADAMS, M. D., CELNIKER, S. E., HOLT, R. A., EVANS, C. A., GOCAYNE, J. D., AMANATIDES, P. G., SCHERER, S. E., LI, P. W., HOSKINS, R. A., GALLE, R. F. et al. 2000. The genome sequence of Drosophila melanogaster. Science 287:2185-2196.
2. ALCEDO, J. and KENYON, C. 2004. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41:45-55.
3. ANDERSON, P., SADEK, M. M., and HANSSON, B. S. 2003. Pre-exposure modulates attraction to sex pheromone in a moth. Chem. Senses 28:285-291.
4. ARANEDA, R. C., KINI, A. D., and FIRESTEIN, S. 2000. The molecular receptive range of an odorant receptor. Nat. Neurosci. 3:1248-1255.
5. BEN-ARIE, N., LANCET, D., TAYLOR, C., KHEN, M., WALKER, N., LEDBETTER, D. H., CARROZZO, R., PATEL, K., SHEER, D., LEHRACH, H. et al. 1994. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Hum. Mol. Genet. 3:229-235.
6. BISSANTZ, C., BERNARD, P., HIBERT, M., and ROGNAN, D. 2003. Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets? Proteins 50:5-25.
7. BRAND, J. G., CAGAN, R. H., and NAIM, M. 1982. Chemical senses in the release of gastric and pancreatic secretions. Annu. Rev. Nutr. 2:249-276.
8. BRAY, S. and AMREIN, H. 2003. A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship. Neuron 39:1019-1029.
9. BREER, H., RAMING, K., and KRIEGER, J. 1994. Signal recognition and transduction in olfactory neurons. Biochim. Biophys. Acta 1224:277-287.
10. BREER, H. 2003. Sense of smell: recognition and transduction of olfactory signals. Biochem. Soc. Trans. 31:113-116.
11. BUCK, L. and AXEL, R. 1991. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187.
12. BUTENANDT, A., GROSCHEL, U., KARSLON, P., and ZILLIG, W. 1959. N-acetyl tyramine, its isolation from Bombyx cocoons and its chemical and biological properties. Arch. Biochem. Biophys. 83:76-83.
13. CHYB, S. 2004. Drosophila gustatory receptors: from gene identification to functional expression. J. Insect Physiol. 50:469-477.
14. CLYNE, P. J., WARR, C. G., FREEMAN, M. R., LESSING, D., KIM, J., and CARLSON, J. R. 1999a. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron 22:327-338.
15. CLYNE, P. J., CERTEL, S. J., DE BRUYNE, M., ZASLAVSKY, L., JOHNSON, W. A., and CARLSON, J. R. 1999b. The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor. Neuron 22:339-347.
16. CLYNE, P. J., WARR, C. G., and CARLSON, J. R. 2000. Candidate taste receptors in Drosophila. Science 287:1830-1834.
17. COYNE, J. A., CRITTENDEN, A. P., and MAH, K. 1994. Genetics of a pheromonal difference contributing to reproductive isolation in Drosophila. Science 265:1461-1464.
18. DE BRUYNE, M., CLYNE, P. J., and CARLSON, J. R. 1999. Odor coding in a model olfactory organ: the Drosophila maxillary palp. J. Neurosci. 19:4520-4532.
19. DE BRUYNE, M., FOSTER, K., and CARLSON, J. R. 2001. Odor coding in the Drosophila antenna. Neuron 30:537-552.
20. DEL PUNTA, K., LEINDERS-ZUFALL, T., RODRIGUEZ, I., JUKAM, D., WYSOCKI, C. J., OGAWA, S., ZUFALL, F., and MOMBAERTS, P. 2002. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419:70-74.
21. DOBRITSA, A. A., VAN DER GOES VAN NATERS, W., WARR, C. G., STEINBRECHT, R. A., and CARLSON, J. R. 2003. Integrating the molecular and cellular basis of odor coding in the Drosophila antenna. Neuron 37:827-841.
22. DROSOPHILA ODORANT RECEPTOR NOMENCLATURE COMMITTEE. 2000. A unified nomenclature system for the Drosophila odorant receptors. Cell 102:145-146.
23. DUNIPACE, L., MEISTER, S., MCNEALY, C., and AMREIN, H. 2001. Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr. Biol. 11:822-835.
24. DWYER, N. D., TROEMEL, E R., SENGUPTA, P., and BARGMANN, C. I. 1998. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell 93:455-466.
25. FOX, A. N., PITTS, R. J., ROBERTSON, H. M., CARLSON, J. R., and ZWIEBEL, L. J. 2001. Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of downregulation in response to blood feeding. Proc. Natl Acad. Sci. USA 98:14693-14697.
26. FOX, A. N., PITTS, R. J., and ZWIEBEL, L. J. 2002. A cluster of candidate odorant receptors from the malaria vector mosquito, Anopheles gambiae. Chem. Senses 27:453-459.
27. FRAZIER, J. L. and HEITZ, J. R. 1975. Electrophysiological studies of the interactions of sulfhydryl reagents with insect olfactory receptors. J. Miss. Acad. Sci. 19:188.
28. GADENNE, C., DUFOUR, M. C., and ANTON, S. 2001. Transient post-mating inhibition of behavioural and central nervous responses to sex pheromone in an insect. Proc. R. Soc. Lond. B. Biol. Sci. 268:1631-1635.
29. GALIZIA, C. G., SACHSE, S., RAPPERT, A., and MENZEL, R. 1999. The glomerular code for odor representation is species specific in the honeybee Apis mellifera. Nat. Neurosci. 2:473-478.
30. GALVEZ, T. and PIN, J. P. 2003. How do G-protein-coupled receptors work? The case of metabotropic glutamate and GABA receptors. Med. Sci. (Paris). 19:559-565.
31. GAO, Q. and CHESS, A. 1999. Identification of candidate Drosophila olfactory receptors from genomic DNA sequence. Genomics 60:31-39.
32. GAO, Q., YUAN, B., and CHESS, A. 2000. Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe. Nat. Neurosci. 3:780-785.
33. GIMELBRANT, A. A., HALEY, S. L., and MC CLINTOCK, T. S. 2001. Olfactory receptor trafficking involves conserved regulatory steps. J. Biol. Chem. 276:7285-7290.
34. GROSSMAN, G. L., RAFFERTY, C. S., CLAYTON, J. R., STEVENS, T. K., MUKABAYINE, O., and BENEDICT, M. Q. 2001. Germline transformation of the malaria vector, Anopheles gambiae, with the piggyBac transposable element. Insect Mol. Biol. 10:597-604.
35. HALLEM, E. A., FOX, A. N., ZWIEBEL, L. J., and CARLSON, J. R. 2004a. Mosquito receptor for human-sweat odorant. Nature 427:212-213.
36. HALLEM, E. A., HO, M. G., and CARLSON, J. R. 2004b. The molecular basis of odor coding in the Drosophila antennae. Cell 117:965-979.
37. HAMMOND, S. M., CAUDY, A. A., and HANNON, G. J. 2001. Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2:110-119.
38. HANDLER, A. M. 2001. A current perspective on insect gene transformation. Insect Biochem. Mol. Biol. 31:111-128.
39. HANSSON, B. S. 1995. Olfaction in lepidoptera. Experientia 51:1003-1027.
40. HILDEBRAND, J. G. 1996. King Solomon Lecture. Olfactory control of behavior in moths: central processing of odor information and the functional significance of olfactory glomeruli. J. Comp. Physiol. A 178:5-19.
41. HILL, C. A., FOX, A. N., PITTS, R. J., KENT, L. B., TAN, P. L., CHRYSTAL, M. A., CRAVCHIK, A., COLLINS, F. H., ROBERTSON, H. M., and ZWIEBEL, L. J. 2002. G protein-coupled receptors in Anopheles gambiae. Science 298:176-178.
42. HOLZENBERGER, M., DUPONT, J., DUCOS, B., LENEUVE, P., GELOEN, A., EVEN, P. C., CERVERA, P., and LE BOUC, Y. 2003. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421:182-187.
43. HYDE, D. R., MECKLENBURG, K. L., POLLOCK, J. A., VIHTELIC, T. S., and BENZER, S. 1990. Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin. Proc. Natl Acad. Sci. USA 87:1008-1012.
44. ITO, K., SUZUKI, K., ESTES, P., RAMASWAMI, M., YAMAMOTO, D., and STRAUSFELD, N. J. 1998. The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen. Learn Mem. 5:52-57.
45. JACQUIN-JOLY, E., FRANÇOIS, M.-C., BURNET, M., LUCAS, P., BOURRAT, F., and MAIDA, R. 2002. Expression pattern in the antennae of a newly isolated lepidopteran Gq protein and subunit cDNA. Eur. J. Biochem. 269:2133-2142.
46. JORDAN, B. A. and DEVI, L. A. 1999. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697-700.
47. KAFKA, W. A. and NEUWIRTH, J. 1975. A model of pheromone molecule-acceptor interaction. Z. Naturforsch. 30:278-282.
48. KALIDAS, S. and SMITH, D. P. 2002. Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron 33:177-184.
49. KIKUCHI, T. 1975. Correlation of moth sex pheromone activities with molecular characteristics involved in conformers of bombykol and its derivatives. Proc. Natl Acad. Sci. USA 72:3337-3341.
50. KRAUTWURST, D., YAU, K. W., and REED, R. R. 1998. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95:917-926.
51. KRIEGER, J. and BREER, H. 1999. Olfactory reception in invertebrates. Science 286:720-723.
52. KRIEGER, J., RAMING, K., DEWER, Y. M. E., BETTE, S., CONZELMANN, S., and BREER H. 2002. A divergent gene family encoding candidate olfactory receptors of the moth Heliothis virescens. Eur. J. Neurosci. 16:619-628.
53. KRIEGER, J., KLINK, O., MOHL, C., RAMING, K., and BREER, H. 2003. A candidate olfactory receptor subtype highly conserved across different insect orders. J. Comp. Physiol. A 189:519-526.
54. KRIEGER, J., GROSSE-WILDE, E., GOHL, T., DEWER, Y. M. E., RAMING, K., and BREER, H. 2004. Genes encoding candidate pheromone receptors in a moth (Heliothis virescens). Proc. Natl Acad. Sci. USA 101:11845-11850.
55. KRISHNAN, B., DRYER, S. E., and HARDIN, P. E. 1999. Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature 400:375-378.
56. LEAL, W. S. 2003. Proteins that make sense, pp. 447-476, in G. J. Blomquist and R. G. Vogt. Insect Pheromone Biochemistry and Molecular Biology, Elsevier, Oxford.
57. L'ETOILE, N. D. and BARGMANN, C. I. 2000. Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1. Neuron 25:575-586.
58. MAIBECHE-COISNE, M., NIKONOV, A. A., ISHIDA, Y., JACQUIN-JOLY, E., and LEAL, W. S. 2004. Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme. Proc. Natl. Acad. Sci. USA 101:11459-11464.
59. MALNIC, B., HIRONO, J., SATO, T., and BUCK, L. B. 1999. Combinatorial receptor codes for odors. Cell 96:713-723.
60. MITA, K., KASAHARA, M., SASAKI, S., NAGAYASU, Y., YAMADA, T., KANAMORI, H., NAMIKI, N., KITAGAWA, M., YAMASHITA, H., YASUKOCHI, Y., et al. 2004. The genome sequence of silkworm, Bombyx mori. DNA Res. 29:27-35.
61. MELO, A. C. A., RUTZLER, M., PITTS, R. J., and ZWIEBEL, L. J. 2004. Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs. Chem. Senses 29:403-410.
62. MERRILL, C. E., RIESGO-ESCOVAR, J., PITTS, R. J., KAFATOS, F. C., CARLSON, J. R., and ZWIEBEL, L. J. 2002. Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. USA 99:1633-1638.
63. MERRILL, C. E., PITTS, R. J., and ZWIEBEL, L. J. 2003. Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae. Insect Mol. Biol. 12:641-50.
64. MILANI, N., GUARIN, E., RENFER, E., NEF, P., and ANDRES-BARQUIN, P. J. 2002. Functional expression of a mammalian olfactory receptor in Caenorhabditis elegans. Chem. Neurosci. 13:2515-2520.
65. MOMBAERTS, P. 1999. Molecular biology of odorant receptors in vertebrates. Annu. Rev. Neurosci. 22:487-509.
66. MOMBAERTS, P. 2004. Odorant receptor gene choice in olfactory sensory neurons: the one receptor-one neuron hypothesis revisited. Curr. Opin. Neurobiol. 14:31-6.
67. MOMBAERTS, P., WANG, F., DULAC, C., CHAO, S. K., NEMES, A., MENDELSOHN, M., EDMONDSON, J., and AXEL, R. 1996. Visualizing an olfactory sensory map. Cell 87:675-686.
68. MUSTAPARTA, H. 1996. Central mechanisms of pheromone information processing. Chem. Senses 21:269-275.
69. NEF, S., ALLAMAN, I., FIUMELLI, H., DE CASTRO, E., and NEF, P. 1996. Olfaction in birds: differential embryonic expression of nine putative odorant receptor genes in the avian olfactory system. Mech. Dev. 55:65-77.
70. NEWCOMB, R. D., SIREY, T. M., JORDAN, M., MARSHALL, S. D. J., TURNER, C., and GREENWOOD, D. R. 2003. Functional genomics of genes involved in odorant reception from the tortricid moth, Epiphyas postvittana. Lepidoptera Abstracts. Abstracts from Sixth International Workshop on the Molecular Biology and Genetics of the Lepidoptera. Journal of Insect Science. 3:16,36. Available online: insectscience.org/3.36.
71. NGAI, J., DOWLING, M. M., BUCK, L., AXEL, R., and CHESS, A. 1993. The family of genes encoding odorant receptors in the channel catfish. Cell 72:657-666.
72. NIGHORN, A., SIMPSON, P. J., and MORTON, D. B. 2001. The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta. J. Exp. Biol. 204:305-314.
73. OHGAMI, N., NAGAI, R., IKEMOTO, M., ARAI, H., KUNIYASU, A., HORIUCHI, S., and NAKAYAMA, H. 2001. CD36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products. J. Biol. Chem. 276:3195-202.
74. OTAKI, J. M. and YAMAMOTO, H. 2003. Length analyses of Drosophila odorant receptors. J. Theor. Biol. 223:27-37.
75. PAGE, T. L. and KOELLING, E. 2003. Circadian rhythm in olfactory response in the antennae controlled by the optic lobe in the cockroach. J. Insect Physiol. 49:697-707.
76. PALCZEWSKI, K., KUMASAKA, T., HORI, T., BEHNKE, C. A., MOTOSHIMA, H., FOX, B. A., LE TRONG, I., TELLER, D. C., OKADA, T., STENKAMP, R. E., YAMAMOTO, M., and MIYANO, M. 2000. Crystal structure of rhodopsin: A G-protein coupled receptor. Science 289:739-745.
77. PECKOL, E. L., TROEMEL, E. R., and BARGMANN, C. I. 2001. Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 98:11032-11038.
78. PFEIFFER, M., KOCH, T., SCHRODER, H., KLUTZNY, M., KIRSCHT, S., KREIENKAMP, H. J., HOLLT, V., and SCHULZ, S. 2001. Homo- and heterodimerization of somatostatin receptor subtypes. J. Biol. Chem. 276:14027-14036.
79. PITTS, R. J., FOX, A. N., and ZWIEBEL, L. J. 2004. A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae. Proc. Natl Acad. Sci. USA 101:5058-5063.
80. QASBA, P. and REED, R. R. 1998. Tissue and zonal-specific expression of an olfactory receptor transgene. J. Neurosci. 18:227-236.
81. RAMING, K., KRIEGER, J., STROTMANN, J., BOEKHOFF, I., KUBICK, S., BAUMSTARK, C., and BREER, H. 1993a. Cloning and expression of odorant receptors. Nature 361:353-356.
82. RAMING, K., FREITAG, J., KRIEGER, J., and BREER, H. 1993b. Arrestin-subtypes in insect antennae. Cell Signal 5:69-80.
83. ROBBINS, M. J., CALVER, A. R., FILIPPOV, A. K., HIRST, W. D., RUSSELL, R. B., WOOD, M. D., NASIR, S., COUVE, A., BROWN, D. A., MOSS, S. J., and PANGALOS, M. N. 2001. GABA (B2) is essential for G-protein coupling of the GABA (B) receptor heterodimer. J. Neurosci. 21:8043-8052.
84. ROBERTSON, H. M. 2001. Updating the str and srj (stl) families of chemoreceptors in Caenorhabditis nematodes reveals frequent gene movement within and between chromosomes. Chem. Senses 26:151-159.
85. ROBERTSON, H. M., WARR, C. G., and CARLSON, J. R. 2003. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 100:14537-14542.
86. RODRIGUES, V. 1988. Spatial coding of olfactory information in the antennal lobe of Drosophila melanogaster. Brain Res. 453:299-307.
87. ROGERS, M. E., SUN, M., LERNER, M. R., and VOGT, R. G. 1997. SNMP-1, a novel membrane protein of olfactory neurons of the silk moth Antheraea polyphemus with homology to the CD 36 family of membrane proteins. J. Biol. Chem. 272:14792-14799.
88. ROGERS, M. E., STEINBRECHT, R. A., and VOGT, R. G. 2001a. Expression of SNMP-1 in olfactory neurons and sensilla of male and female antennae of the silkmoth Antheraea polyphemus. Cell Tissue Res. 303:433-446.
89. ROGERS, M. E., KRIEGER, J., and VOGT, R. G. 2001b. Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a unique family of invertebrate CD 36-like proteins. J. Neurobiol. 49:47-61.
90. SCOTT, K., BRADY, R. Jr., CRAVCHIK, A., MOROZOV, P., RZHETSKY, A., ZUKER, C., and AXEL, R. 2001. A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104:661-673.
91. SENGUPTA, P., CHOU, J. H., and BARGMANN, C. I. 1996. Odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell 84:899-909.
92. SERIZAWA, S., ISHII, T., NAKATANI, H., TSUBOI, A., NAGAWA, F., ASANO, M., SUDO, K., SAKAGAMI, J., SAKANO, H., IJIRI, T., MATSUDA, Y., SUZUKI, M., YAMAMORI, T., IWAKURA, Y., and SAKANO, H. 2000. Mutually exclusive expression of odorant receptor transgenes. Nat. Neurosci. 3:687-693.
93. SMITH, D. P., SHIEH, B. H., and ZUKER, C. S. 1990. Isolation and structure of an arrestin gene from Drosophila. Proc. Natl. Acad. Sci. USA 87:1003-1007.
94. STELINSKI, L. L., MILLER, J. R., RESSA, N. E., and GUT, L. J. 2003. Increased EAG responses of tortricid moths after prolonged exposure to plant volatiles: evidence for octopamine-mediated sensitization. J. Insect Physiol. 49:845-856.
95. STENGL, M., ZINTL, R., DE VENTE, J., and NIGHORN, A. 2001. Localization of cGMP immunoreactivity and of soluble guanylyl cyclase in antennal sensilla of the hawkmoth Manduca sexta. Cell Tissue Res. 304:409-421.
96. STEINBRECHT, R. A., OZAKI, M., and ZIEGELBERGER, G. (1992) Immunocytochemical localization of pheromone-binding protein in moth antennae. Cell Tissue Res. 270:287-302.
97. STOCKER, R. F. 1994. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res. 275:3-26.
98. STOCKER, R. F. 2001. Drosophila as a focus in olfactory research: mapping of olfactory sensilla by fine structure, odor specificity, odorant receptor expression, and central connectivity. Microsc. Res. Tech. 55:284-296.
99. STÖRTKHUL, K. F. and KETTLER, R. 2001. Functional analysis of an olfactory receptor in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 98:9381-9385.
100. STROTMANN, J., LEVAI, O., FLEISCHER, J., SCHWARZENBACHER, K., and BREER, H. 2004. Olfactory receptor proteins in axonal processes of chemosensory neurons. J. Neurosci. 24:7754-7761.
101. TAKKEN, W., VAN LOON, J. J., and ADAM, W. 2001. Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding. J. Insect Physiol. 47:303-310.
102. TAMURA, T., THIBERT, C., ROYER, C., KANDA, T., ABRAHAM, E., KAMBA, M., KOMOTO, N., THOMAS, J. L., MAUCHAMP, B., CHAVANCY, G., SHIRK, P., FRASER, M., PRUDHOMME, J.-C., and COUBLE, P. 2000. Germline transformation of the silkworm Bombyx mori L. using a piggyBac transposon derivated vector. Nat. Biotech. 18:81-84.
103. TANOUE, S., SUMIDA, S., SUETSUGU, T., ENDO, Y., and NISHIOKA, T. 2001. Identification of a receptor type guanylyl cyclase in the antennal lobe and antennal sensory neurons of the silkmoth, Bombyx mori. Insect Biochem. Mol. Biol. 31:971-979.
104. TATAR, M., KOPELMAN, A., EPSTEIN, D., TU, M. P., YIN, C. M., and GAROFALO, R. S. 2001. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292:107-110.
105. TERRILLON, S. and BOUVIER, M. 2004. Roles of G-protein-coupled receptor dimerization. EMBO Rep. 5:30-34.
106. TOUHARA, K., SENGOKU, S., INAKI, K., TSUBOI, A., HIRONO, J., SATO, T., SAKANO, H., and HAGA, T. 1999. Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl. Acad. Sci. USA 96:4040-1045.
107. TOUHARA, K. 2002. Odor discrimination by G protein-coupled olfactory receptors. Microsc. Res. Tech. 58:135-141.
108. TROEMEL, E. R., CHOU, J. H., DWYER, N. D., COLBERT, H. A., and BARGMANN, C. I. 1995. Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell 83:207-218.
109. VILLET, R. H. 1974. Involvement of amino and sulfhydryl groups in olfactory transduction in silkmoths. Nature 248:707-709.
110. VILLET, R. H. 1978. Mechanism of insect sex-pheromone sensory transduction: role of adenyl cyclase. Comp. Biochem. Physiol. 61C:389-394.
111. VOGT, R. G. 2003. Biochemical diversity of odor detection: OBPs, ODEs and SNMPs. pp. 391-445, in G. J. Blomquist and R. G. Vogt. Insect Pheromone Biochemistry and Molecular Biology. Elsevier, Oxford.
112. VOGT, R. G. and RIDDIFORD, L. M. 1981. Pheromone binding and inactivation by moth antennae. Nature 293:161-163.
113. VOGT, R. G., PRESTWICH, G. D., and RIDDIFORD, L. M. 1988. Sex pheromone receptor proteins. Visualization using a radiolabeled photoaffinity analog. J. Biol. Chem. 263:3952-3959.
114. VOSSHALL, L. B., AMREIN, H., MOROZOV, P. S., RZHETSKY, A., and AXEL, R. 1999. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell 96:725-736.
115. VOSSHALL, L. B., WONG, A. M., and AXEL, R. 2000. An olfactory sensory map in the fly brain. Cell 102:147-159.
116. VOSSHALL, L. B. 2001. The molecular logic of olfaction in Drosophila. Chem. Senses 26:207-213.
117. WANG, F., NEMES, A., MENDELSOHN, M., and AXEL, R. 1998. Odorant receptors govern the formation of a precise topographic map. Cell 93:47-60.
118. WETZEL, C. H., OLES, M., WELLERDIECK, C., KUCZKOWIAK, M., GISSELMANN, G., and HATT, H. 1999. Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus laevis oocytes. J. Neurosci. 19:7426-7433.
119. WETZEL, C. H., BEHRENDT, H.-J., GISSELMANN, G., STÖRTKHUL, K. F., HOVEMANN, B., and HATT, H. 2001. Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc. Natl. Acad. Sci. USA 98:9377-9380.
120. WHITFIELD, C. W., BAND, M. R., BONALDO, M. F., KUMAR, C. G., LIU, L., PARDINAS, J. R., ROBERTSON, H. M., SOARES, M. B., and ROBINSON, G. E. 2002. Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee. Genome Res. 12:555-566.
121. WIECZOREK, H. and SCHWEIKL, H. 1985. Concentrations of cyclic nucleotids and activities of cyclases and phosphodiesterases in an insect chemosensory organ. Insect Biochem. 6:723-728.
122. WITZGALL, P., LINDBLOM, T., BENGTSSON, M., and TÓTH, M. 2004. The Pherolist. www-pherolist.slu.se.
123. YU, S., AVERY, L., BAUDE, E., and GARBERS, D. L. 1997. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc. Natl. Acad. Sci. USA 94:3384-3387.
124. ZHANG, Y., CHOU, J. H., BRADLEY, J., BARGMANN, C. I., and ZINN, K. 1997. The Caenorhabditis elegans seven-transmembrane protein ODR-10 functions as an odorant receptor in mammalian cells. Proc. Natl. Acad. Sci. USA 94:12162-12167.
125. ZHANG, X. and FIRESTEFN, S. 2002. The olfactory receptor gene superfamily of the mouse. Nat. Neurosci. 5:124-133.
126. ZHAO, H., IVIC, L., OTAKI, J. M., HASHIMOTO, M., MIKOSHIBA, K., and FIRESTEIN, S. 1998. Functional expression of a mammalian odorant receptor. Science 279:237-242.
127. ZUFALL, F. and LEINDERS-ZUFALL, T. 2000. The cellular and molecular basis of odor adaptation. Chem. Senses 25:473-481.
128. ZWIEBEL, L. J. and TAKKEN W. 2004. Olfactory regulation of mosquito-host interactions. Insect Biochem. Mol. Biol. 34:645-652.