Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

Journal of Clinical Investigation

Volumn 97, Issue 10, 1996, Pages 2225-2232

  Neuenschwander, Stefan ^a   Schwartz, Arnold ^b   Wood, Teresa L ^c   Roberts Jr , Charles T ^a   Henninghausen, Lothar ^a   LeRoith, Derek ^a,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

apoptosis; insulin like growth factors; lactation; transgenic whey acidic protein gene

Indexed keywords

ACID PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; FEMALE; HISTOLOGY; HYBRID GENE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INVOLUTION; LACTATION; MAMMARY GLAND; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0029946896     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118663     Document Type: Article

References (32)

1. Rillema, J.A. 1994. Development of the mammary gland and lactation. Trends Endocrinol. Metab. 5:149-154.
2. Forsyth, I.A. 1989. Growth factors in mammary gland function. J. Reprod. Fertil. 85:759-770.
3. Forsyth, I.A. 1991. The mammary gland. Bailliere's Clin. Endocrinol. Metab. 5:809-832.
4. Daniel, C.W., and G.B. Silberstein. 1987. Postnatal development of the rodent mammary gland. In The Mammary Gland. M.C. Neville and C.W. Daniel, editors. Plenum Publishing Corp., New York. 1-36.
5. Lyons, W.R., C.H. Li, and R.F. Johnson. 1958. The hormonal control of mammary growth and lactation. Recent Prog. Horm. Res. 14:219-254.
6. Kleinberg, D.L., R. Weifeng, V. Catanese, C.B. Newman, and M. Feldman. 1990. Non-lactogenic effects of growth hormone on growth and insulin-like growth factor-I messenger ribonucleic acid of rat mammary gland. Endocrinology. 126:3274-3276.
7. Plaut, K., M. Ikeda, and B.K. Vonderhaar. 1993. Role of growth hormone and insulin-like growth factor-I in mammary development. Endocrinology. 133: 1843-1848.
8. Rechler, M.M. 1993. Insulin-like growth factor binding proteins. Vitam. Horm. 47:1-99.
9. Donovan, S.M., R.L. Hintz, and R.G. Rosenfeld. 1995. Investigation into the potential physiological sources of rat milk IGF-1 and IGF-binding proteins. J. Endocrinol. 145:569-578.
10. Grosvenor, C.E., M.F. Picciano, and C.R. Baumrucker. 1993. Hormones and growth factors in milk. Endocr. Rev. 14:710-728.
11. Yee, D., K.J. Cullen, S. Paik, J.F. Perdue, B. Hampton, A. Schwartz, M.E. Lippman, and N. Rosen. 1988. Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res. 48:6691-6696.
12. Yee, D., S. Paik, G.S. Lebovic, R.R. Marcus, R.E. Faconi, K.J. Cullen, M.E. Lippman, and N. Rosen. 1989. Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol. Endocrinol. 3:509-517.
13. Prosser, C.G., M.D. Baucells, and I.R. Fleet. 1992. Transfer of insulin-like growth factors I and II from plasma to lymph in young goats. Exp. Physiol. 77:575-585.
14. Campbell, P.G., T.C. Skaar, J.R. Vega, and C.R. Baumrucker. 1991. Secretion of insulin-like growth factor-I (IGF-I) and IGF-binding proteins from bovine mammary tissue in vivo J. Endocrinol. 128:219-228.
15. Roberts, C.T. Jr., S.R. Lasky, W.L. Lowe, Jr., W.T. Seaman, and D. LeRoith. 1987. Molecular cloning of rat insulin-like growth factor 1 complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues. Mol Endocrinol. 1: 243-248.
16. Shimatsu, A., and P. Rotwein. 1987. Sequence of two rat insulin-like growth factor 1 mRNAs differing within the 5′-untranslated region. Nucleic Acids Res. 15:7196-7202.
17. Adamo, M.L., H. Ben-Hur, C.T. Roberts, Jr. and D. LeRoith. 1991. Regulation of start site usage in the leader exons of the rat IGF-I gene by development, fasting and diabetes. Mol. Endocrinol. 5:1677-1686.
18. Chen, J.-C., Z.-M. Shao, S. Sheikh., A. Hussain, D. LeRoith, C.T. Roberts, Jr., and J.A. Fontana. 1994. Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line. J. Cell. Physiol. 158:69-78.
19. Burdon, T., L. Sankaran, R.J. Wall, M. Spencer, and L. Henninghausen. 1991. Expression of a whey acidic protein transgene during mammary development: evidence for different mechanisms of regulation during pregnancy and lactation. J. Biol. Chem. 266:6909-6914.
20. Gordon, J.W. 1992. Production of transgenic mice. In Methods in Enzymology. Guide to Techniques in Mouse Development. Vol. 225. P. W. Wasserman and M. L. Depamphilis, editors. Academic Press, New York. 747-770.
21. Cathala, G., J.F. Savouret, B. Mendez, B.L. West, M. Karin, J.A. Martial, and J.D. Baxter. 1983. A method for isolation of intact, translationally active ribonucleic acid, DNA (NY). 2:329-335.
22. Shimasaki, S., A. Koba, M. Mercado, M. Shimonaka, and N. Ling. 1989. Complementary DNA structure of the high molecular weight rat insulin-like growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA. Biochem. Biophys. Res. Commun. 165:907-912.
23. Ichinose, R.R., and S. Nanci. 1964. Lobuloaveolar differentiation in mouse mammary tissues in vitro. Science (Wash. DC). 145:496-497.
24. Ichinose, R.R., and S. Nandi. 1966. Influence of hormones on lobuloalveolar differentiation of mouse mammary gland in vitro. J. Endocrinol. 35:331-340.
25. Silberstein, G.B., and C.W. Daniel. 1987. Investigation of mouse mammary ductal growth regulation using slow-release plastic implants. J. Dairy Sci. 70:1981-1990.
26. Hauser, S.D., M.F. McGrath, R.J. Collier, and G.G. Krivi. 1990. Cloning and in vivo expression of bovine growth hormone receptor mRNA. Mol. Cell. Endocrinol. 72:187-200.
27. Ruan, W., C.B. Newman, and D.L. Kleinberg. 1992. Intact and amino-terminally shortened forms of insulin-like growth factor-I induce mammary gland differentiation and development. Proc. Natl. Acad. Sci. USA. 89:10872-10876.
28. Strange, F., F. Li, S. Saurer, A. Burkhardt, and R.R. Friis. 1992. Apoptotic cell death and tissue remodeling during mouse mammary gland involution. Development (Camb.). 115:49-58.
29. Harrington, E.A., M.R. Bennett, A. Fanidi, and G.I. Evan. 1994. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO (Eur. Mol. Biol. Organ.) J. 13:3286-3295.
30. Marcotty, C., F. Frankenne, S. Meuris, and G. Hennen. 1994. Immunolocalization and expression of insulin-like growth factor I (IGF-I) in the mammary gland during rat gestation and lactation. Mol. Cell. Endocrinol. 99: 237-243.
31. Li, B., N. Greenberg, L.C. Stephens, R. Meyn, D. Medina, and J.M. Rosen. 1994. Preferential overexpression of a 172Arg→Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth & Differ. 5:711-721.
32. Hadsell, D.L., N.M. Greenberg, J.M. Fligger, C.R. Baumrucker, and J.M. Rosen. 1996. Targeted expression of des(1-3) human insulin-like growth factor-I in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology. 137:321-330.