-
1
-
-
3042728494
-
Drug discovery - The leading edge
-
Chapman T. Drug discovery - the leading edge. Nature. 430:2004;109
-
(2004)
Nature
, vol.430
, pp. 109
-
-
Chapman, T.1
-
2
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3:2004;711-715
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
3
-
-
0036633359
-
Genome-based pharmacogenetics and the pharmaceutical industry
-
Roses A. Genome-based pharmacogenetics and the pharmaceutical industry. Nat. Rev. Drug Discov. 1:2002;541-549
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 541-549
-
-
Roses, A.1
-
4
-
-
0028904620
-
Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome
-
Aono S., et al. Analysis of genes for bilirubin UDP- glucuronosyltransferase in Gilbert's syndrome. Lancet. 345:1995;958-959
-
(1995)
Lancet
, vol.345
, pp. 958-959
-
-
Aono, S.1
-
5
-
-
0033984655
-
Clinical trials in the genomic era: Effects of protective genotypes on sample size and duration of trial
-
Fijal B.A., et al. Clinical trials in the genomic era: effects of protective genotypes on sample size and duration of trial. Control. Clin. Trials. 21:2000;7-20
-
(2000)
Control. Clin. Trials
, vol.21
, pp. 7-20
-
-
Fijal, B.A.1
-
6
-
-
0030030762
-
Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
-
Monaghan G., et al. Genetic variation in bilirubin UPD- glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet. 347:1996;578-581
-
(1996)
Lancet
, vol.347
, pp. 578-581
-
-
Monaghan, G.1
-
7
-
-
0037441560
-
Fulfilling the promise: Drug discovery in the post-genomic era
-
Chanda S., Caldwell J. Fulfilling the promise: drug discovery in the post-genomic era. Drug Discov. Today. 8:2003;168-174
-
(2003)
Drug Discov. Today
, vol.8
, pp. 168-174
-
-
Chanda, S.1
Caldwell, J.2
-
8
-
-
1242285664
-
Biotechnology: Identifying advances from the hype
-
Glassman R., Sun A. Biotechnology: identifying advances from the hype. Nat. Rev. Drug Discov. 3:2004;177-183
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 177-183
-
-
Glassman, R.1
Sun, A.2
-
9
-
-
0037085583
-
Cellular platforms for HTS: Three case studies
-
Johnston P.A., Johnston P.A. Cellular platforms for HTS: three case studies. Drug Discov. Today. 7:2002;353-363
-
(2002)
Drug Discov. Today
, vol.7
, pp. 353-363
-
-
Johnston, P.A.1
Johnston, P.A.2
-
10
-
-
4444262688
-
The knockout mouse project
-
Austin C.P., et al. The knockout mouse project. Nat. Genet. 36:2004;921-924
-
(2004)
Nat. Genet.
, vol.36
, pp. 921-924
-
-
Austin, C.P.1
-
11
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drews J. Drug discovery: a historical perspective. Science. 287:2000;1960-1964
-
(2000)
Science
, vol.287
, pp. 1960-1964
-
-
Drews, J.1
-
14
-
-
0035953873
-
Cancer - Improved mouse models
-
Berns A. Cancer - improved mouse models. Nature. 410:2001;1043-1044
-
(2001)
Nature
, vol.410
, pp. 1043-1044
-
-
Berns, A.1
-
15
-
-
4344649384
-
Opinion: Genetically modified mouse models for pharmacogenomic research
-
Liggett S.B. Opinion: genetically modified mouse models for pharmacogenomic research. Nat. Rev. Genet. 5:2004;657-663
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 657-663
-
-
Liggett, S.B.1
-
16
-
-
0141758327
-
Predicting drug efficacy: Knockouts model pipeline drugs of the pharmaceutical industry
-
Zambrowicz B.P., et al. Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry. Curr. Opin. Pharmacol. 3:2003;563-570
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 563-570
-
-
Zambrowicz, B.P.1
-
17
-
-
0037267313
-
Knockouts model the 100 best-selling drugs - Will they model the next 100?
-
Zambrowicz B.P., Sands A. Knockouts model the 100 best-selling drugs - will they model the next 100? Nat. Rev. Drug Discov. 2:2003;38-51
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.2
-
18
-
-
0036517472
-
A comprehensive review of genetic association studies
-
Hirschhorn J., et al. A comprehensive review of genetic association studies. Genet. Med. 4:2002;45-61
-
(2002)
Genet. Med.
, vol.4
, pp. 45-61
-
-
Hirschhorn, J.1
-
19
-
-
4143134235
-
The future of association studies: Gene-based analysis and replication
-
Neale B., Sham P. The future of association studies: gene-based analysis and replication. Am. J. Hum. Genet. 75:2004;353-362
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 353-362
-
-
Neale, B.1
Sham, P.2
-
20
-
-
0037312921
-
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
-
Lohmueller K., et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33:2003;177-182
-
(2003)
Nat. Genet.
, vol.33
, pp. 177-182
-
-
Lohmueller, K.1
-
21
-
-
0037442235
-
Genetic associations in large versus small studies: An empirical assessment
-
Ioannidis J., et al. Genetic associations in large versus small studies: an empirical assessment. Lancet. 361:2003;567-571
-
(2003)
Lancet
, vol.361
, pp. 567-571
-
-
Ioannidis, J.1
-
22
-
-
0036255811
-
Candidate-gene approaches for studying complex genetic traits: Practical considerations
-
Tabor H.K., et al. Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat. Rev. Genet. 3:2002;391-397
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 391-397
-
-
Tabor, H.K.1
-
23
-
-
1642399172
-
Betting odds and genetic associations
-
Thomas D., Clayton D. Betting odds and genetic associations. J. Natl. Cancer Inst. 96:2004;421-423
-
(2004)
J. Natl. Cancer Inst.
, vol.96
, pp. 421-423
-
-
Thomas, D.1
Clayton, D.2
-
24
-
-
0033780104
-
How many diseases does it take to map a gene with SNPs
-
Weiss K., Terwilliger J. How many diseases does it take to map a gene with SNPs. Nat. Genet. 26:2000;151-157
-
(2000)
Nat. Genet.
, vol.26
, pp. 151-157
-
-
Weiss, K.1
Terwilliger, J.2
-
25
-
-
0034660559
-
Searching for genetic determinants in the new millennium
-
Risch N. Searching for genetic determinants in the new millennium. Nature. 405:2000;847-856
-
(2000)
Nature
, vol.405
, pp. 847-856
-
-
Risch, N.1
-
26
-
-
0037426052
-
Problems of reporting genetic associations with complex outcomes
-
Colhoun H.M., et al. Problems of reporting genetic associations with complex outcomes. Lancet. 361:2003;865-872
-
(2003)
Lancet
, vol.361
, pp. 865-872
-
-
Colhoun, H.M.1
-
27
-
-
13544255351
-
Post-approval R&D raises total drug development costs to $897 million
-
May-June
-
Tufts Center for the Study of Drug Development (2003) Post-approval R&D raises total drug development costs to $897 million. Impact Report: Analysis and Insight into Critical Drug Development Issues 5, May-June
-
(2003)
Impact Report: Analysis and Insight into Critical Drug Development
, Issue.5
-
-
-
28
-
-
0034567325
-
Genomic impact on pharmaceutical development
-
Venter J.C. Genomic impact on pharmaceutical development. Novartis Foundation Symposium. 229:2000;14-18
-
(2000)
Novartis Foundation Symposium
, vol.229
, pp. 14-18
-
-
Venter, J.C.1
-
29
-
-
0035819474
-
Implications of the Human Genome Project for medical science
-
Collins F., McKusick V. Implications of the Human Genome Project for medical science. J. Am. Med. Assoc. 285:2001;540-544
-
(2001)
J. Am. Med. Assoc.
, vol.285
, pp. 540-544
-
-
Collins, F.1
McKusick, V.2
-
30
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander E., et al. Initial sequencing and analysis of the human genome. Nature. 409:2001;860-921
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.1
-
31
-
-
0035895505
-
The sequence of the human genome
-
Venter J., et al. The sequence of the human genome. Science. 291:2001;1304
-
(2001)
Science
, vol.291
, pp. 1304
-
-
Venter, J.1
-
33
-
-
0242363264
-
Innovation - Target discovery
-
Lindsay M. Innovation - target discovery. Nat. Rev. Drug Discov. 2:2003;831-838
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 831-838
-
-
Lindsay, M.1
-
34
-
-
0345304425
-
Pharmacogenetics goes genomic
-
Goldstein D., et al. Pharmacogenetics goes genomic. Nat. Rev. Genet. 4:2003;937-947
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 937-947
-
-
Goldstein, D.1
-
35
-
-
0033624575
-
The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler D., et al. The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26:2000;76-80
-
(2000)
Nat. Genet.
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
-
36
-
-
0035861048
-
Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
-
Martin E., et al. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. J. Am. Med. Assoc. 286:2001;2245-2250
-
(2001)
J. Am. Med. Assoc.
, vol.286
, pp. 2245-2250
-
-
Martin, E.1
-
37
-
-
0037173639
-
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
-
Van Eerdewegh P., et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 418:2002;426-430
-
(2002)
Nature
, vol.418
, pp. 426-430
-
-
Van Eerdewegh, P.1
-
38
-
-
6344237686
-
Association of the DTNBP1 Locus with Schizophrenia in a U.S. Population
-
Funke B., et al. Association of the DTNBP1 Locus with Schizophrenia in a U.S. Population. Am. J. Hum. Genet. 75:2004;891-898
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 891-898
-
-
Funke, B.1
-
39
-
-
4544225882
-
Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia
-
Duan J., et al. Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. Am. J. Hum. Genet. 75:2004;624-638
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 624-638
-
-
Duan, J.1
-
40
-
-
0038389762
-
IBD5 is a general risk factor for inflammatory bowel disease: Replication of association with Crohn disease and identification of a novel association with ulcerative colitis
-
Giallourakis C., et al. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. Am. J. Hum. Genet. 73:2003;205-211
-
(2003)
Am. J. Hum. Genet.
, vol.73
, pp. 205-211
-
-
Giallourakis, C.1
-
41
-
-
0042329759
-
Pharmacogenetics and disease genetics of complex diseases
-
Schmith V., et al. Pharmacogenetics and disease genetics of complex diseases. Cell. Mol. Life Sci. 60:2003;1636-1646
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, pp. 1636-1646
-
-
Schmith, V.1
-
42
-
-
0030274647
-
Genomic sciences and the medicine of tomorrow
-
Drews J. Genomic sciences and the medicine of tomorrow. Nat. Biotechnol. 14:1996;1516-1518
-
(1996)
Nat. Biotechnol.
, vol.14
, pp. 1516-1518
-
-
Drews, J.1
-
44
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
-
Sachidanandam R., et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 409:2001;928-933
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
Sachidanandam, R.1
-
45
-
-
19944429029
-
The relationship between atherogenic dyslipidemia and the adult treatment program-III definition of metabolic syndrome: The Genetic Epidemiology of Metabolic Syndrome Project
-
(in press)
-
Wyszynski, D.F. et al. The relationship between atherogenic dyslipidemia and the adult treatment program-III definition of metabolic syndrome: The Genetic Epidemiology of Metabolic Syndrome Project. Am. J. Cardiol (in press)
-
Am. J. Cardiol
-
-
Wyszynski, D.F.1
-
46
-
-
0035092024
-
Flow cytometric platform for high-throughput single nucleotide polymorphism analysis
-
Taylor J.D., et al. Flow cytometric platform for high-throughput single nucleotide polymorphism analysis. Biotechniques. 30:2001;661-669
-
(2001)
Biotechniques
, vol.30
, pp. 661-669
-
-
Taylor, J.D.1
-
47
-
-
0034060781
-
A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension
-
Chen J., et al. A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension. Genome Res. 10:2000;549-557
-
(2000)
Genome Res.
, vol.10
, pp. 549-557
-
-
Chen, J.1
-
48
-
-
84950435288
-
A network algorithm for performing Fisher's Exact Test in r×c contingency tables
-
Mehta C., Patel N. A network algorithm for performing Fisher's Exact Test in r×c contingency tables. J. Am. Stat. Assoc. 78:1983;427-434
-
(1983)
J. Am. Stat. Assoc.
, vol.78
, pp. 427-434
-
-
Mehta, C.1
Patel, N.2
-
49
-
-
4143134235
-
The future of association studies: Gene-based analysis and replication
-
Neale B., Sham P. The future of association studies: gene-based analysis and replication. Am. J. Hum. Genet. 75:2004;353-362
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 353-362
-
-
Neale, B.1
Sham, P.2
-
50
-
-
0035257236
-
Association study designs for complex diseases
-
Cardon L., Bell J. Association study designs for complex diseases. Nat. Rev. Genet. 2:2001;91-99
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 91-99
-
-
Cardon, L.1
Bell, J.2
-
51
-
-
0036452837
-
SNPs - Where's the beef?
-
Roses A. SNPs - where's the beef? Pharmacogenomics J. 2:2002;277-283
-
(2002)
Pharmacogenomics J.
, vol.2
, pp. 277-283
-
-
Roses, A.1
-
52
-
-
18244378312
-
Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine
-
McCarthy L., et al. Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics. 78:2001;135-149
-
(2001)
Genomics
, vol.78
, pp. 135-149
-
-
McCarthy, L.1
-
53
-
-
18344392840
-
Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map
-
Hewett D., et al. Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map. Genomics. 79:2002;305-314
-
(2002)
Genomics
, vol.79
, pp. 305-314
-
-
Hewett, D.1
-
54
-
-
0033910787
-
A test for linkage and association in general pedigrees: The pedigree disequilibrium test
-
Martin E., et al. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am. J. Hum. Genet. 67:2000;146-154
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 146-154
-
-
Martin, E.1
-
55
-
-
0034785352
-
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
-
Rioux J., et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29:2001;223-228
-
(2001)
Nat. Genet.
, vol.29
, pp. 223-228
-
-
Rioux, J.1
-
56
-
-
2642583283
-
Mapping complex disease loci in whole-genome association studies
-
Carlson C., et al. Mapping complex disease loci in whole-genome association studies. Nature. 429:2004;446-452
-
(2004)
Nature
, vol.429
, pp. 446-452
-
-
Carlson, C.1
-
57
-
-
0036071235
-
A note on the calculation of empirical P values from Monte Carlo procedures
-
North B.V., et al. A note on the calculation of empirical P values from Monte Carlo procedures. Am. J. Hum. Genet. 71:2002;439-441
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 439-441
-
-
North, B.V.1
-
60
-
-
4344684441
-
Pharmacogenetics and drug development: The path to safer and more effective drugs
-
Roses A. Pharmacogenetics and drug development: the path to safer and more effective drugs. Nat. Rev. Genet. 5:2004;645-655
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 645-655
-
-
Roses, A.1
|