Predicting drug efficacy: Knockouts model pipeline drugs of the pharmaceutical industry

Current Opinion in Pharmacology

Volumn 3, Issue 5, 2003, Pages 563-570

  Zambrowicz, Brian P ^a   Turner, C Alexander ^a   Sands, Arthur T ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR AGONIST; BVT 933; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; CILOMILAST; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPLERENONE; EXENDIN 4; FASIDOTRIL; GI 181771; GLP 1; GLUCAGON LIKE PEPTIDE 1; GW 493838; HORMONE RECEPTOR STIMULATING AGENT; IFETROBAN; MONOCLONAL ANTIBODY; MORPHINE; N TERT BUTYL 4 [5' ETHOXY 4 (2 MORPHOLINOETHOXY) 2' OXOSPIRO[CYCLOHEXANE 1,3' INDOLE] 1' SULFONYL] 3 METHOXYBENZAMIDE; NICOTINE; OMALIZUMAB; OMAPATRILAT; PHOSPHODIESTERASE IV INHIBITOR; RIMONABANT; ROFLUMILAST; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; TACHYKININ RECEPTOR ANTAGONIST; TAK 637; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANXIETY; BEHAVIOR DISORDER; CANCER THERAPY; CARDIOVASCULAR DISEASE; CLINICAL STUDY; CLINICAL TRIAL; CORRELATION ANALYSIS; DEPRESSION; DIABETES MELLITUS; DOSE RESPONSE; DRUG APPROVAL; DRUG DEPENDENCE; DRUG EFFICACY; DRUG INDUSTRY; DRUG RESEARCH; DRUG TARGETING; EXPERIMENTAL MODEL; GENE SEQUENCE; HUMAN; HUMAN GENOME; HYPERALGESIA; HYPERTENSION; INFLAMMATORY DISEASE; KNOCKOUT MOUSE; LIFESPAN; MOUSE; MUSCLE WEAKNESS; NONHUMAN; OBESITY; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; VALIDATION PROCESS; VISCERAL PAIN;

ANIMALS; DRUG DESIGN; DRUG INDUSTRY; GENOME, HUMAN; HUMANS; MICE; MICE, KNOCKOUT; PHENOTYPE; TECHNOLOGY, PHARMACEUTICAL;

EID: 0141758327     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2003.04.002     Document Type: Review

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