Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 4, 2002, Pages 630-637

  Aiello, Robert J ^a   Brees, Dominique ^a   Bourassa, Patricia Ann ^a   Royer, Lori ^a   Lindsey, Saralyn ^a   Coskran, Timothy ^a   Haghpassand, Mehrdad ^a   Francone, Omar L ^a  

^a PFIZER INC   (United States)

Author keywords

ABCA1; Atherosclerosis; HDL; Xanthomatosis

Indexed keywords

ABC TRANSPORTER; APOLIPOPROTEIN E; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BONE MARROW TRANSPLANTATION; GENE INACTIVATION; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPID METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANGIER DISEASE; XANTHOMATOSIS;

ANIMALS; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BONE MARROW TRANSPLANTATION; CHOLESTEROL; CROSSES, GENETIC; FEMALE; HYPERLIPIDEMIAS; LIPIDS; LIPOPROTEINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; RECEPTORS, LDL; XANTHOMATOSIS;

EID: 0036120566     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000014804.35824.DA     Document Type: Article

References (37)

1. The human ATP-binding cassette (ABC) transporter superfamily
2. The human ATP-binding cassette (ABC) transporter superfamily
3. Molecular cloning of the human ATP binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
4. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
5. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
6. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
7. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
8. A PPAR-gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
9. Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells
10. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
11. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
12. The ATP binding cassette transporter ABC1 is required for the engulfment of corpses generated by apoptotic cell death
13. Interleukin-1β secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1
14. ABC1, an ATP binding cassette transporter is required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes
15. Mutations in ABC1 in Tangier disease and familial high density lipoprotein deficiency
16. The gene encoding ATP binding cassette transporter 1 is mutated in Tangier disease
17. Tangier disease is caused by mutations in the gene encoding ATP binding cassette transporter 1
18. Hypercatabolism of lipoprotein-free apolipoprotein A-I in HDL-deficient mutant chickens
19. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
20. Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency
21. Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease
22. Metabolism of high-density lipoprotein apolipoproteins in Tangier disease
23. A simple method for the isolation and purification of total lipids form animal tissues
24. Estrogen reduces atherosclerosis lesion development in apolipoprotein E-deficient mice
25. Monocyte/ macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
26. High-density lipoprotein cholesterol and cardiovascular disease: Four prospective American studies
27. High density lipoprotein deficiency syndrome in chickens is not associated with an increased susceptibility to atherosclerosis
28. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
29. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice
30. β-sitosterolemia and xanthomatosis
31. Massive xanthomatosis and altered composition of atherosclerotic lesions and hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
32. Novel approaches to treating cardiovascular disease: Lessons from Tangier disease
33. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
34. Absence of P-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein E-deficient mice
35. Evidence for an altered lipid metabolic state in circulating blood monocytes under conditions of hyperlipidemia in swine and its implications in arterial lipid metabolism
36. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes
37. ATP-binding cassette transporter A1 (ABCA1) in macrophages: A dual function in inflammation and lipid metabolism?