Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 2021-2029

  Kienzle, Norbert ^a,b   Olver, Stuart ^a   Buttigieg, Kathy ^a   Groves, Penny ^a   Janas, Michelle L ^a   Baz, Adriana ^a   Kelso, Anne ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; GRANZYME B; INTERLEUKIN 4; MESSENGER RNA; PERFORIN;

ARTICLE; CELL ACTIVATION; CELL CLONING; CELL DIFFERENTIATION; CELL ISOLATION; CLONING; CYTOLYSIS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; T LYMPHOCYTE;

EID: 13544266571     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.2021     Document Type: Article

References (54)

1. Trapani, J. A., and M. J. Smyth. 2002. Functional significance of the perforin/ granzyme cell death pathway. Nat. Rev. Immunol. 2:735.
2. Johnson, H., L. Scorrano, S. J. Korsmeyer, and T. J. Ley. 2003. Cell death induced by granzyme C. Blood 101:3093.
3. + T cells can be primed in vitro to produce IL-4. J. Immunol. 148:1652.
4. - cells that make TH2 cytokines and help B cells. Science 260:1802.
5. Croft, M., L. Carter, S. L. Swain, and R. W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profites. J. Exp. Med. 180:1715.
6. + T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions. Proc. Natl. Acad. Sci. USA 94:8070.
7. Moran, T. M., H. Isobe, A. Fernandez-Sesma, and J. L. Schulman. 1996. Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. J. Virol. 70:5230.
8. Kaji, M., M. Kobayashi, R. B. Pollard, and F. Suzuki. 2000. Influence of type 2 T cell responses on the severity of encephalitis associated with influenza virus infection. J. Leukocyte Biol. 68:180.
9. Villacres, M. C., and C. C. Bergmann. 1999. Enhanced cytotoxic T cell activity in IL-4-deficient mice. J. Immunol. 162:2663.
10. Jackson, R. J., A. J. Ramsay, C. D. Christensen, S. Beaton, D. F. Hall, and I. A. Ramshaw. 2001. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. J. Virol. 75:1205.
11. Sharma, D. P., A. J. Ramsay, D. J. Maguire, M. S. Rolph, and I. A. Ramshaw. 1996. Interleukin-4 mediates down-regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo. J. Virol. 70:7103.
12. Bembridge, G. P., J. A. Lopez, R. Cook, J. A. Melero, and G. Taylor. 1998. Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or γ interferon. J. Virol. 72:4080.
13. + respiratory syncytial virus-specific cytotoxic T-lymphocyte activity in vivo. J. Virol. 73:8944.
14. Van den Broek, M., M. F. Bachmann, G. Kohler, M. Barner, R. Escher, R. Zinkernagel, and M. Kopf. 2000. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-γ and nitric oxide synthetase 2. J. Immunol. 164:371.
15. + T cells. Microbes Infect. 5:923.
16. + T cell subpopulations in established pulmonary metastases. J. Immunol. 162:6671.
17. Kemp, R. A., and F. Ronchese. 2001. Tumor-specific Tc1, but not Tc2. cells deliver protective antitumor immunity. J. Immunol. 167:6497.
18. Helmich, B. K., and R. W. Dutton. 2001. The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors. J. Immunol. 166:6500.
19. + T-cell responses in mice homozygous for disruption of the interleukin-4 gene. J. Virol. 71:2518.
20. Santra, S., and S. K. Ghosh. 1997. Interleukin-4 is effective in restoring cytotoxic T cell activity that declines during in vivo progression of a murine B lymphoma. Cancer Immunol. Immunother. 44:291.
21. Bachmann, M. F., H. Schorle, R. Kuhn, W. Muller, H. Hengartner, R. M. Zinkemagel, and I. Horak. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J. Virol. 69:4842.
22. + T cells secreting Th1 or Th2 cytokines. Immunity 2:271.
23. Carter, L. L., and R. W. Dutton. 1995. Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J. Immunol. 155:1028.
24. Cerwenka, A., L. L. Carter, J. B. Reome, S. L. Swain, and R. W. Dutton. 1998. In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. J. Immunol. 161:97.
25. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. J. Exp. Med. 180:489.
26. Kienzle, N., K. Buttigieg, P. Groves, T. Kawula, and A. Kelso. 2002. A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression. J. Immunol. 168:1672.
27. low phenotype, an alternative career choice for CD8 T cells during primary differentiation. Immunol. Cell Biol. 82:75.
28. + thymocyte differentiation. Immunity 5:461.
29. Viola, A., M. Salio, L. Tuosto, S. Linkert, O. Acuto, and A. Lanzavecchia. 1997. Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J. Exp. Med. 186:1775.
30. Chidgey, A., and R. Boyd. 1997. Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression. Int. Immunol. 9:1527.
31. + T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or IL-6. Int. Immunol. 4:475.
32. Fitzpatrick, D. R., and A. Kelso. 1995. Dissociated expression of granulocyte-macrophage CSF and IL-3 in short-term T cell clones from normal mice. J. Immunol. 155:5140.
33. + cells induced by protein immunization. Immunology 83:25.
34. + T cells. Immunology 93:341.
35. + T cell response to protein immunization. Int. Immunol. 6:1515.
36. + T cells during primary activation. Int. Immunol. 14:605.
37. + T cells in influenza virus-infected mice. Proc. Natl. Acad. Sci. USA 100:2657.
38. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901.
39. + T cell population isolated from an effector site contains cells with flexible cytokine profiles. J. Exp. Med. 190:1081.
40. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
41. Egwuagu, C. E., C. R. Yu, M. Zhang, R. M. Mahdi, S. J. Kim, and I. Gery. 2002. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168:3181.
42. Pestano, G. A., Y. Zhou, L. A. Trimble, J. Daley, G. F. Weber, and H. Cantor. 1999. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science 284:1187.
43. Gao, G. F., and B. K. Jakobsen. 2000. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21:630.
44. Holler, P. D., and D. M. Kranz. 2003. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 18:255.
45. + T cell clones can provide B cell help. J. Immunol. 154:3118.
46. Wu-Hsieh, B. A., J. K. Whitmire, R. de Fries, J. S. Lin, M. Matloubian, and R. Ahmed. 2001. Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. J. Immunol. 167:4566.
47. Moore, M. L., C. C. Brown, and K. R. Spindler. 2003. T cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitis. J. Virol. 77:10060.
48. + cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-αβ and CD8 molecules. Immunology 102:209.
49. dull suppressor cells in spleens of mice intraperitoneally infected with E. multilocularis. J. Immunol. 147:1659.
50. low thymocytes in the HIV type 1-infected thymus. J. Immunol. 169:2788.
51. + individuals. Blood 92:198.
52. Trautmann, A., B. Ruckert, P. Schmid-Grendelmeier, E. Niederer, E. B. Brocker, K. Blaser, and C. A. Akdis. 2003. Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology 108:305.
53. Zhang, Z. X., L. Yang, K. J. Young, B. DuTemple, and L. Zhang. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 6:782.
54. + T cell as immune regulatory cell. J. Mol. Med. 79:419.