Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo

Journal of Virology

Volumn 70, Issue 10, 1996, Pages 7103-7107

  Sharma, Dharam P ^a   Ramsay, Alistair J ^a   Maguire, Deborah J ^a   Rolph, Michael S ^a   Ramshaw, Ian A ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; VACCINIA; VACCINIA VIRUS;

EID: 0029819130     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.7103-7107.1996     Document Type: Article

References (36)

1. Actor, J. K., M. Shirai, M. C. Kullberg, R. M. L. Buller, A. Sher, and J. Berzofsky. 1993. Helminth infection results in decreased virus-specific CD8+ cytotoxic T cell and Th1 cytokine responses as well as delayed virus clearance. Proc. Natl. Acad. Sci. USA 90:948-952.
2. Andrew, M. E., and B. E. H. Coupar. 1992. Biological effects of recombinant vaccinia virus-expressed interleukin-4. Cytokine 4:281-286.
3. Andrew, M. E., B. E. H. Coupar, G. L. Ada, and D. B. Boyle. 1986. Cell-mediated immune responses to influenza virus antigens expressed by vaccinia virus recombinants. Microb. Pathog. 1:443-452.
4. Blanden, R. V. 1974. T cell responses to viral and bacterial infection. Transplant. Rev. 19:56-88.
5. Cenci, E., L. Romani, A. Mencacci, R. Spaccapelo, E. Schiaffella, P. Puccetti, and F. Bistoni. 1993. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 23: 1034-1038.
6. Chouaib, S., J. Chehimi, L. Bani, N. Genetel, T. Tursz, F. Gay, G. Trinchieri, and F. Mami-Chouaib. 1994. Interleukin-12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T lymphocyte precursors into allospeciflc cytotoxic effectors. Proc. Natl. Acad. Sci. USA 91: 12659-12663.
7. H2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
8. Coupar, B. E. H., M. E. Andrew, and D. B. Boyle. 1988. A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes. Gene 68:1-10.
9. Coutelier, J.-P., J. van Broeck, and S. F. Wolf. 1995. Interleukin-12 gene expression after viral infection in the mouse. J. Virol. 69:1955-1958.
10. Coyle, A. J., F. Erard, C. Bertrand, S. Walti, H. Pircher, and G. Le Gros. 1995. Virus-specific CD8+ cells can switch to interleukin-5 production and induce airway eosinophilia. J. Exp. Med. 181:1229-1233.
11. Croft, M., L. Carter, S. L. Swain, and R. W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715-1728.
12. H2 cytokines and help B cells. Science 260:1802-1805.
13. Flexner, C., A. Hugin, and B. Moss. 1987. Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression. Nature (London) 330:259-262.
14. Green, S. J., and C. A. Nacy. 1993. Antimicrobial and immunopathologic effects of cytokine-induced nitric oxide synthesis. Curr. Opin. Infect. Dis. 6:384-396.
15. Gromo, G., R. L. Geller, L. Inverardi, and F. H. Bach. 1987. Signal requirements in the step-wise functional maturation of cytotoxic T lymphocytes. Nature (London) 327:424-426.
16. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguel. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742-1745.
17. Hu-Li, J., J. Ohara, C. Watson, W. Tsang, and W. E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that cell line (CT.4S). J. Immunol. 142:800-807.
18. Karupiah, G., B. E. H. Coupar, M. E. Andrew, D. B. Boyle, S. M. Phillips, A. Mulbacher, R. V. Blanden, and I. A. Ramshaw. 1990. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2. J. Immunol. 144:290-298.
19. Karupiah, G., Q.-W. Xie, R. M. L. Buller, C. Nathan, C. Duarte, and J. D. MacMicking. 1993. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 261:1445-1448.
20. Kohonen-Corish, M. R. J., N. J. C. King, C. E. Woodhams, and I. A. Ramshaw. 1990. Immunodeficient mice recover from infection with vaccinia virus expressing interferon-γ. Eur. J. Immunol. 20:157-161.
21. Lefkovits, I., and H. Waldmann. 1984. Limiting dilution analysis of the cells of immune system. I. The clonal basis of the immune response. Immunol. Today 5:265-268.
22. h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur. J. Immunol. 21:2489-2494.
23. Martinez, O. M., R. S. Gibbons, M. R. Garovoy, and F. R. Aronson. 1990. IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells. J. Immunol. 144:2211-2215.
24. Modlin, R. L., and T. B. Nutman. 1993. Type 2 cytokines and negative immune regulation in human infections. Curr. Opin. Immunol. 5:511-517.
25. Ramsay, A. J., A. J. Husband, I. A. Ramshaw, S. Bao, K. I. Matthaei, G. Koehler, and M. Kopf. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264:561-563.
26. Ramsay, A. J., J. Ruby, and I. A. Ramshaw. 1993. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today 14:155-157.
27. Ramshaw, I., J. Ruby, A. Ramsay, G. Ada, and G. Karupiah. 1992. Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo. Immunol. Rev. 127:157-182.
28. Ramshaw, I. A., M. E. Andrew, S. M. Phillips, D. B. Boyle, and B. E. H. Coupar. 1987. Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection. Nature (London) 329:545-546.
29. Rockett, K. A., M. M. Awburn, E. S. Rockett, W. B. Cowden, and I. A. Clark. 1994. Possible role of nitric oxide in malarial immunosuppression. Parasite Immunol. 16:243-249.
30. + T cells is dependent on interferon-γ. Lymphokinc Cytokine Res. 10:353-358.
31. Salcedo, T. W., L. Azzoni, S. F. Wolf, and B. Perussia. 1993. Modulation of pcrforin and granzyme messenger RNA expression in human natural killer cells. J. Immunol. 151:2511-2520.
32. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279-282.
33. Schwarz, E. M., P. Salgame, and B. R. Bloom. 1993. Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Proc. Natl. Acad. Sci. USA 90:7734-7738.
34. Seder, R., and W. E. Paul. 1994. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12:635-673.
35. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
36. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:73-178.