The CD4+ T-cell response to protein immunization is independent of accompanying IFN-γ-producing CD8+ T cells

Immunology

Volumn 93, Issue 3, 1998, Pages 341-349

  Doyle, A G ^a   Ramm, L ^a   Kelso, A ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; IMMUNIZATION; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HEMOCYANIN; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; TIME FACTORS;

EID: 0031941560     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00404.x     Document Type: Article

References (43)

1. + T cells and clones activated in vivo and in vitro. Immunol Rev 123, 85.
2. SALGAME P., ABRAMS J.S., CLAYBERGER C., GOLDSTEIN H., CONVIT J., MODLIN R.L. & BLOOM B.R. (1991) Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254, 279.
3. + T cells that secrete IFN-γ and IL-5. J Immunol 145, 68.
4. BAUMGARTH N., BROWN L., JACKSON D. & KELSO A. (1994) Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma-interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10. J Virol 68, 7575.
5. + cells can switch to interleukin 5 production and induce airway eosinophilia. J Exp Med 181, 1229.
6. + T cells in asthma. Immunol Cell Biol 74, 206.
7. CROFT M., CARTER L., SWAIN S.L. & DUTTON R.W. (1994) Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 180, 1715.
8. WENNER C.A., GÜLER M.L., MACATONIA S.E., O'GARRA A. & MURPHY K.M. (1996) Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J Immunol 156, 1442.
9. SZABO S.J., DIGHE A.S., GUBLER U. & MURPHY K.M. (1997) Regulation of interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 185, 817.
10. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178, 889.
11. + T cells. Immuolgy 78, 226.
12. lo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice. Eur J Immunol 25, 2551.
13. ROTTENBERG M.E., SPORRONG L., PERSSON I., WIGZELL H. & ÖRN A. (1995) Cytokine gene expression during infection of mice lacking CD4 and/or CD8 with Trypanasoma cruzi. Scand J Immunol 41, 164.
14. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 59, 1155.
15. + cells. J Immunol 155, 2396.
16. STAERZ U.D., KARASUYAMA H. & GARNER A.M. (1987) Cytotoxic T lymphocytes against a soluble protein. Nature 329, 449.
17. CARBONE F.R. & BEVAN M.J. (1990) Class 1-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med 171, 377.
18. YEFENOF E., ZEHAVI-FEFERMAN R. & GUY R. (1990) Control of primary and secondary antibody responses by cytotoxic T lymphocytes specific for a soluble antigen. Eur J Immunol 20, 1849.
19. ROCK K.L. & CLARK K. (1996) Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class 1 presentation pathway. J Immunol 156, 3721.
20. + T cell response to protein immunization. Int Immunol 6, 1515.
21. HEINZEL F.P., SADICK M.D., HOLADAY B.J., COFFMAN R.L. & LOCKSLEY R.M. (1989) Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 169, 59.
22. + T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or IL-6. Int Immunol 4, 475.
23. + T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions. Proc Natl Acad Sci USA 94, 8070.
24. KELSO A. & METCALF D. (1985) Clonal heterogeneity in colony stimulating factor production by murine T lymphocytes. J Cell Physiol 123, 101.
25. SANDER B., HÖIDÉN I., ANDERSSON U., MÖLLER E. & ABRAMS J.S. (1993) Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods 166, 201.
26. + cells induced by protein immunization. Immunology 83, 25.
27. SARMIENTO M., GLASEBROOK A.L. & FITCH F.W. (1980) IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 125, 2665.
28. CHERWINSKI H.M., SCHUMACHER J.H., BROWN K.D. & MOSMANN T.R. (1987) Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166, 1229.
29. GERMANN T., GUCKES S., BONGARTZ M. et al. (1995) Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE. Int Immunol 7, 1649.
30. SPRENT J. (1994) T and B memory cells. Cell 76, 315.
31. CHEN W., CARBONE F.R. & MCCLUSKEY J. (1993) Electroporation and commercial liposomes efficiently deliver soluble protein into the MHC class I presentation pathway. Priming in vitro and in vivo for class I-restricted recognition of soluble antigen. J Immunol Methods 160, 49.
32. MAGRAM J., CONNAUGHTON S.E., WARRIER R.R. et al. (1996) IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4, 471.
33. HUANG S., HENDRIKS W., ALTHAGE A. et al. (1993) Immune response in mice that lack interferon-γ receptor. Science 259, 1742.
34. - helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4 and interferon-γ. J Exp Med 174, 547.
35. VAN DEN EERTWEGH A.J.M., NOELLE R.J., ROY M. et al. (1993) In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand. cytokines, and antibody production delineates sites of cognate TB cell interactions. J Exp Med 178, 1555.
36. NORBURY C.C., HEWLETT L.J., PRESCOTT A.R., SHASTRI N. & WATTS C. (1995) Class 1 MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3, 783.
37. BEVAN M.J. (1995) Antigen presentation to cytotoxic T lymphocytes in vivo. J Exp Med 182, 639.
38. COUTELIER J.-P., VAN DER LOGT J.T.M., HEESSEN F.W.A., VINK A. & VAN SNICK J. (1988) Virally induced modulation of murine IgG antibody subclasses. J Exp Med 168, 2373.
39. + T cells can be primed in vitro to produce IL-4. J Immunol 148, 1652.
40. -CD4 cells that make Th2 cytokines and help B cells. Science 260, 1802.
41. + cells. J Exp Med 183, 1001.
42. WESTERMANN J., PERSIN S., MATYAS J., VAN DER MEIDE P. & PABST R. (1993) IFN-γ influences the migration of thoracic duct B and T lymphocyte subsets in vivo. Random increase in disappearance from the blood and differential decrease in reappearance in the lymph. J Immunol 150, 3843.
43. KRAAL G., SCHORNAGEL K., SAVELKOUL H. & MARUYAMA T. (1994) Activation of high endothelial venules in peripheral lymph nodes. The involvement of interferon-gamma. Int Immunol 6, 1195.