Adipocyte insensitivity syndromes - Novel approach to nutritional metabolic problems including obesity and obesity related disorders

Medical Hypotheses

Volumn 64, Issue 4, 2005, Pages 826-832

  Erol, Adnan ^a  

^a Silivri City Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; FAT; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; LONG CHAIN FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOCYTE INSENSITIVITY SYNDROME; ARTICLE; ATHEROSCLEROSIS; BIOCHEMISTRY; FATTY ACID OXIDATION; HUMAN; INSULIN RESISTANCE; LIPODYSTROPHY; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 13444269285     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.09.017     Document Type: Article

References (47)

1. L. Chao, B. Marcus-Samuels, M.M. Mason, and M.L. Reitman Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones J Clin Invest 106 2000 1221 1228
2. B.B. Kahn, and J.S. Flier Obesity and insulin resistance J Clin Invest 106 2000 473 481
3. A. Garg Lipodystrophias Am J Med 108 2000 143 152
4. O. Gavrilova, L.R. Leon, C. Vinson, and M.L. Reitman Leptin and diabetes in lipoatrophic mice Nature 403 2000 850 851
5. J. Moitra, M.M. Mason, M. Olive, D. Krylov, and O. Gavrilova Life without white fat: a transgenic mouse Genes Dev 12 1998 3168 3181
6. O. Gavrilova, B. Marcus-Samuels, D. Graham, and M.L. Reitman Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice J Clin Invest 105 2000 271 278
7. M. Caron, M. Auclair, and C. Vigouroux The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance Diabetes 50 2001 1378 1388
8. J.E. Pessin, D.C. Thurmond, and J.S. Elmendorf Molecular basis of insulin-stimulated GLUT4 vesicle trafficking J Biol Chem 274 1999 2593 2596
9. P.R. Shepherd, and B.B. Kahn Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus N Engl J Med 341 1999 248 257
10. K.K. Jason, M.M. Dodson, and B.B. Kahn Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle J Clin Invest 105 2000 1791 1797
11. E.D. Abel, D. Peroni, and B.B. Kahn Adipose selective targeting of the GLUT4 gene impairs insulin action in muscle and liver Nature 409 2001 729 733
12. E. Tozzo, L. Gnudi, and B.B. Kahn Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter Endocrinology 138 1997 1604 1611
13. J.M. Friedman Obesity in the new millennium Nature 404 2000 632 634
14. P.H. Weinstock, S. Levak-Frank, and L.C. Hudgins Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase Proc Natl Acad Sci USA 94 1997 10261 10266
15. M.-Y. Wang, Y. Lee, and R.H. Unger Novel form of lipolysis induced by leptin J Biol Chem 274 1999 17541 17544
16. H. Shimano, N. Yahagi, M. Amemiya-Kudo, A.H. Hasty, and J. Osuga Sterol regulatory element binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J Biol Chem 274 1999 35832 35839
17. J.B. Kim, and B.M. Spigelman ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev 10 1996 1096 1107
18. A.H. Hasty, H. Shimano, N. Yahagi, and M.A. Kudo Sterol regulatory element binding protein-1 is regulated by glucose at the transcriptional level J Biol Chem 275 2000 31069 31077
19. J.B. Kim, P. Sarraf, M. Wright, and B.M. Spiegelman Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J Clin Invest 101 1998 1 9
20. S. Mandrup, and M.D. Lane Regulating adipogenesis J Biol Chem 272 1997 5367 5370
21. J.B. Kim, H.M. Wright, and B.M. Spigelman ADD1/SREBP1 activates PPARγ through the production of endogenous ligand Proc Natl Acad Sci USA 95 1998 4333 4337
22. T.J. Kieffer, and J.F. Habenar The adipoinsular axis: effects of leptin on pancreatic β-cells Am J Physiol (Endocrinol metab) 278 2000 E1 E14
23. Y.T. Zhou, M. Shimabukuro, K. Koyama, and R.H. Unger Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation Proc Natl Acad Sci USA 94 1997 6386 6390
24. M.-Y. Wang, Y. Lee, and R.H. Unger Novel form of lipolysis induced by leptin J Biol Chem 274 1999 17541 17544
25. C. Fleury, M. Neverova, and S. Collins Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia Nat Genet 15 1997 269 272
26. N. Ouchi, S. Kihara, Y. Arita, K. Maeda, and Y. Matsuzawa Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin Circulation 100 1999 2473 2476
27. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, and Y. Matsuzawa Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-[kappa]B signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
28. K. Hotta, T. Funahashi, N. Bodkin, and Y. Matsuzawa Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys Diabetes 50 2001 1126 1133
29. B.G. Marques, D.B. Hausman, and R.J. Martin Association of fat cell size and paracrine growth factors in development of hyperplastic obesity Am J Physiol (Regulatory Integrative Comp Physiol) 275 1998 R1898 R1908
30. G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance Science 259 1993 87 91
31. C.M. Steppan, S.T. Bailey, and M.A. Lazar The hormon resistin. Links obesity to diabetes Nature 409 2001 307 312
32. J.F. Nils, and J. Knudsen Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signaling Biochem J 323 1997 1 12
33. M. Shimabukuro, Y.T. Zhou, M. Levi, and R.H. Unger Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes Proc Natl Acad Sci USA 95 1998 2498 2502
34. V. Zammit The malonyl-CoA, long-chain acyl-CoA axis in the maintenance of mammalian cell function Biochem J 343 1999 505 515
35. A. Erol Energy dense high-carbohydrate and low-fat diets are the reason for the epidemic of metabolic syndrome - novel approach to etiopathogenesis of metabolic syndrome Turkish J Endocrinol Metab 1 2001 1 16
36. E. Duplus, M. Glorian, and C. Forest Fatty acid regulation of gene transcription J Biol Chem 275 2000 30749 30752
37. M.S. Brown, and J.L. Goldstein The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340
38. A. Brunetti, L. Brunetti, D. Foti, D. Accili, and I.D. Goldfine Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene J Clin Invest 97 1997 258 262
39. I. Shimomura, Y. Bashmakov, S. Ikemoto, J.D. Horton, M.S. Brown, and J.L. Goldstein Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes Proc Natl Acad Sci USA 96 1999 13656 13661
40. P.-H. Ducluzeau, N. Perretti, and M. Laville Regulation by insulin of gene expression in human skeletal muscle and adipose tissue Diabetes 50 2001 1134 1142
41. I. Barroso, M. Gurnell, and S. O'Rahilly Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension Nature 402 1999 880 883
42. S.A. McCune, and R.A. Harris Mechanism responsible for 5-(tetradexyloxy)-2-furoic acid inhibition of hepatic lipogenesis J Biol Chem 254 1979 10095 10101
43. G.F. Merrill, E.J. Kurth, D.G. Hardie, and W.W. Winder AICAriboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle Am J Physiol (Endocrinol Metab) 273 1997 E1107 E1112
44. H. Makimura, T.M. Mizuno, and X.-J. Yang Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting Diabetes 50 2001 733 739
45. C. Bouchard Inhibition of food intake by inhibitors of fatty acid synthase N Engl J Med 343 2000 1888 1889
46. A. Erol Effects of high fat diet on body mass index and metabolic parameters Obezite 5 2001 44 48
47. T. Yamauchi, J. Kamon, and T. Kadowaki Replenishment of fat-derived hormone adiponectin reverses insulin resistance in lipoatrophic diabetes and type 2 diabetes Diabetes 50 Suppl 2 2001 pA70