Transforming growth factor-β predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage

Journal of Rheumatology

Volumn 24, Issue 3, 1997, Pages 536-542

  Lafeber, Floris P J G ^a   Van Roy, Hanneke L A M ^a   Van Der Kraan, Peter M ^b   Van Den Berg, Wim B ^b   Bijlsma, Johannes W J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cartilage; chondrocyte; human; osteoarthritis; proteoglycan; transforming growth factor

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS;

AGED; AGED, 80 AND OVER; AUTORADIOGRAPHY; CARTILAGE; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HUMANS; MALE; OSTEOARTHRITIS; PHENOTYPE; PROTEOGLYCANS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030947810     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Lafeber FPJG, Van Roy HLAM, Wilbrink B, Huber-Bruning O, Bijlsma JWJ: Human osteoarthritic cartilage is synthetically more active but in culture less vital than normal cartilage. J Rheumatol 1992;19:123-9.
2. Lafeber FPJG, van der Kraan PM, Van Roy HLAM, et al: Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage. Am J Pathol 1992;140:1421-9.
3. Wahl SM: Transforming growth factor β: The good, the bad, and the ugly. J Exp Med 1994;180:1587-90.
4. Harvey AK, Hrubey PS, Chandrasekhar S: TGFβ inhibition of IL activity involves down-regulation of IL-1 receptors on chondrocytes. Exp Cell Res 1991;195:376-85.
5. Hardingham TE, Bayliss MT, Rayan V, Noble DP: Effects of growth factors and cytokines on proteoglycan turnover in articular cartilage. Br J Rheumatol 1992;31:1-6.
6. Van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB: Does TGFβ protect articular cartilage in vivo? Agents Actions 1993;39:127-31.
7. Redini F, Mauviele A, Pronost S, Loyau G, Pujol JP: TGFβ exerts opposite effects from IL-1β on cultured rabbit articular chondrocytes through reduction of IL-1 receptor expression. Arthritis Rheum 1993;36:44-50.
8. Livne E, Weiss A: In vitro effects of hormones and growth factors on the incorporation of [3H]leucine, [35S]sulphate and [3H]proline by chondrocytes of aging mice. Mech Ageing Dev 1993;72:213-29.
9. Redini F, Daireaux M, Mauviel A, Galera P, Loyau G, Pujol JP: Characterisation of proteoglycans synthesized by rabbit articular chondrocytes in response to TGFβ. Biochim Biophys Acta 1991;1093:196-206.
10. Van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB: TGFβ1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee. Lab Invest 1994;71:279-90.
11. Gunther M, Hausebeck HD, van de Leur E, et al: TGFβ 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated articular chondrocytes. Arthritis Rheum 1994;37:395-405.
12. Campbell IK, Wotta J, Novak U, Hamilton JA: Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage chondrocytes. Down regulation by tumor necrosis factor alpha and upregulation by TGFβ basic fibroblast growth factor. Biochim Biophys Acta 1994;1226:277-85.
13. Benya PD, Padilla SR: Dihydrocytochalasin B enhances TGF-beta-induced reexpression of the differentiated chondrocyte phenotype without stimulation of collagen synthesis. Exp Cell Res 1993;204:268-17.
14. Van der Kraan PM, Vitters EL, van den Berg WB: Inhibition of proteoglycan synthesis by TGFβ in anatomically intact articular cartilage. Ann Rheum Dis 1992;51:643-7.
15. Rayan V, Hardingham T: The recovery of articular cartilage in explant culture from IL-1α: Effects on proteoglycan synthesis and degradation. Matrix Biol 1994;14:263-71.
16. Verschure PJ, Joosten LA, van der Kraan PM, van den Berg WB: Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors. Ann Rheum Dis 1994;53:455-60.
17. Von den Hoff, De Koning MH, Van Kampen GP, van der Korst JK: TGFβ stimulates retinoic acid-induced proteoglycan depletion in intact articular cartilage. Arch Biochem Biophys 1994;313:241-7.
18. Malemud CJ, Killeen W, Hering TM, Purchio AF: Enhanced sulfated proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant TGFβ1. J Cell Physiol 1991;149:152-9.
19. Lafeber FPJG, van der Kraan PM, Huber-Bruning O, van den Berg WB, Bijlsma JWJ: Osteoarthritic human cartilage is more sensitive to transforming growth factor β than normal cartilage. Br J Rheumalol 1993;32:281-6.
20. Ballock RT, Heydemann A, Wakefield LM, Flanders KC, Roberts AB, Sporn MB: TGFβ 1 prevents hypertrophy of epiphyseal chondrocyles: Regulation of gene expression for cartilage matrix protein metalloproteases. Dev Biol 1993;158:414-29.
21. Van der Kraan PM, Vitters EL, van den Berg WB: Differential effect of TGF-β on freshly isolated and cultured articular chondrocytes. J Rheumatol 1992;19:140-5.
22. Glansbeek HL, van der Kraan PM, Vitters EL, van den Berg WB: Correlation of the size of type II TGFβ receptor with TGFβ responses of isolated bovine articular chondrocytes. Ann Rheum Dis 1993;52:812-6.
23. Vivien D, Galera P, Lebrun E, Loyau G, Pujol JP: Differential effects of TGF-β and epidermal growth factor on cell cycle of cultured rabbit articular chondrocytes. J Cell Physiol 1990;143:534-45.
24. Vivien D, Galera P, Loyau G, Pujol JP: Differential response of cultured rabbit articular chondrocytes to TGFβ evidence for a role of serum factors. Eur J Cell Biol 1991;54:217-23.
25. Vivien D, Redini F, Galera P, Lebrun E, Loyau G, Pujol JP: Rabbit articular chondrocytes express distinct TGFB receptor phenotypes as a function of cell cycle phases. Exp Cell Res 1993;205:165-70.
26. Galera P, Redini F, Vivien D, et al: Effects of TGFβ on matrix synthesis by monolayer cultures of rabbit articular chondrocytes during differentiation process. Exp Cell Res 1992;200:319-92.
27. Lafeber FPJG, van der Kraan PM, Van Roy JLAM, Huber-Bruning O, Bijlsma JWJ: Articular cartilage explant culture; an appropriate in vitro system to compare osteoarthritic and normal human cartilage. Connect Tissue Res 1993;29:287-99.
28. Mankin HJ, Dorfman H, Lippiello L, Zarnis A: Biochemical and metabolic abnormalities in articular cartilage obtained from osteoarthritic human hips: II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg 1971;53:523-37.
29. van Valburg AA, Wenting MJG, Beekman B, Te Koppele JM, Lafeber FPJG, Bijlsma JWJ: Degenerated human articular cartilage at autopsy represents preclinical osteoarthritic cartilage: Comparison with clinically defined osteoarthritic cartilage. J Rheumatol 1997;24:358-64.
30. Ronziére M-C, Ricard-Blum S, Tiollier J, Hartmann DJ, Garrone R, Herbage D: Comparative analysis of collagen solubilized from human foetal, and normal and osteoarthritic adult articular cartilage, with an emphasis on type VI collagen. Biochem Biophys Acta 1990;1038:220-30.
31. Fava R, Olson N, Keski-Oja J, Moses H, Pincus T: Active and latent forms of TGFβ activity in synovial effusions. J Exp Med 1989;169:291-6.
32. Suzuki A, Shioda N, Maeda T, Tada M, Ueno N: Cloning of an isoform of mouse TGF-beta type II receptor gene. FEBS Lett 1994;355:19-22.
33. Glansbeek HL, van der Kraan PM, Lafeber FPJG, Vitters EL, van den Berg WB: Species specific expression of type II TGFβ receptor isoforms by articular chondrocytes: Effect of proteoglycan depletion and aging. Cytokine 1997;(in press).