Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction - The case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway

Protein Science

Volumn 13, Issue 3, 2004, Pages 786-796

  Sikora, Sergey ^a   Godzik, Adam ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Conservation; Evolutionary trace; HIF 1 ; Phylogeny; Tumorigenic mutations; VHL

Indexed keywords

AMINO ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TUMOR SUPPRESSOR PROTEIN; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; ARTICLE; GENOME; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTERACTION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANIMALS; ATP-DEPENDENT PROTEASES; CONSERVED SEQUENCE; HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; PHYLOGENY; PROTEIN BINDING; PROTEIN CONFORMATION; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SURFACE PROPERTIES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EUKARYOTA;

EID: 1342268062     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03454904     Document Type: Article

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