메뉴 건너뛰기




Volumn 1, Issue 1, 2004, Pages 61-68

Identifying orphan G protein coupled receptors in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; BOMBESIN RECEPTOR; CALCIUM ION; CRE RECOMBINASE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LIGAND; ORPHAN G PROTEIN COUPLED RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

EID: 13344294986     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2004.06.004     Document Type: Review
Times cited : (3)

References (23)
  • 1
    • 1642545591 scopus 로고    scopus 로고
    • Developing functional GPCR screens
    • W.J. Thomsen et al. Developing functional GPCR screens Curr. Drug Discovery Dev. 6 2004 13-18
    • (2004) Curr. Drug Discovery Dev. , vol.6 , pp. 13-18
    • Thomsen, W.J.1
  • 2
    • 0037446894 scopus 로고    scopus 로고
    • The G protein coupled receptor repertoires of human and mouse
    • D.K. Vassilatis et al. The G protein coupled receptor repertoires of human and mouse Proc. Nat. Acad. Sci. USA 100 2003 4903-4908
    • (2003) Proc. Nat. Acad. Sci. USA , vol.100 , pp. 4903-4908
    • Vassilatis, D.K.1
  • 3
    • 0242352645 scopus 로고    scopus 로고
    • Continued discovery of ligands for G protein-coupled receptors
    • D.K. Lee et al. Continued discovery of ligands for G protein-coupled receptors Life Sci. 74 2003 293-297
    • (2003) Life Sci. , vol.74 , pp. 293-297
    • Lee, D.K.1
  • 4
    • 0037082324 scopus 로고    scopus 로고
    • Target validation of G protein coupled receptors
    • A. Wise et al. Target validation of G protein coupled receptors Drug Discovery Today 7 2002 235-246
    • (2002) Drug Discovery Today , vol.7 , pp. 235-246
    • Wise, A.1
  • 5
    • 1342281272 scopus 로고    scopus 로고
    • The identification of ligands at orphan G-protein coupled receptors
    • A. Wise et al. The identification of ligands at orphan G-protein coupled receptors Ann. Rev. Pharmacol. Toxicol. 44 2004 43-66
    • (2004) Ann. Rev. Pharmacol. Toxicol. , vol.44 , pp. 43-66
    • Wise, A.1
  • 6
    • 0036669944 scopus 로고    scopus 로고
    • Strategies to identify ligands for orphan G-protein coupled receptors
    • G. Milligan Strategies to identify ligands for orphan G-protein coupled receptors Biochem. Soc. Trans. 30 2002 789-793
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 789-793
    • Milligan, G.1
  • 7
    • 0034801665 scopus 로고    scopus 로고
    • G protein coupled receptor drug discovery: Implications from the crystal structure of rhodopsin
    • J. Ballesteros et al. G protein coupled receptor drug discovery: implications from the crystal structure of rhodopsin Curr. Drug Discovery Dev. 4 2001 561-574
    • (2001) Curr. Drug Discovery Dev. , vol.4 , pp. 561-574
    • Ballesteros, J.1
  • 8
    • 0032699862 scopus 로고    scopus 로고
    • Exploring the dynamics of regulation of G protein coupled receptors using green fluorescent protein
    • G. Milligan Exploring the dynamics of regulation of G protein coupled receptors using green fluorescent protein Br. J. Pharmacol. 128 1999 501-510
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 501-510
    • Milligan, G.1
  • 9
    • 1842477318 scopus 로고    scopus 로고
    • Targeting GPCRs in silico
    • March
    • G. Jenkins Targeting GPCRs in silico Curr. Drug Discovery March 2004 23-26
    • (2004) Curr. Drug Discovery , pp. 23-26
    • Jenkins, G.1
  • 10
    • 4243133144 scopus 로고    scopus 로고
    • Privileged structure based combinatorial libraries targeting G protein coupled receptors
    • T. Guo et al. Privileged structure based combinatorial libraries targeting G protein coupled receptors Assays Drug Dev. Tech. 1 2003 579-592
    • (2003) Assays Drug Dev. Tech. , vol.1 , pp. 579-592
    • Guo, T.1
  • 11
    • 0037020329 scopus 로고    scopus 로고
    • Drug design strategies for targeting G-protein coupled receptors
    • K. Klabunde et al. Drug design strategies for targeting G-protein coupled receptors Chem. BioChem. 3 2002 928-944
    • (2002) Chem. BioChem. , vol.3 , pp. 928-944
    • Klabunde, K.1
  • 12
    • 0036688175 scopus 로고    scopus 로고
    • The use of constitutively active GPCRs in drug discovery and functional genomics
    • D.T. Chalmers et al. The use of constitutively active GPCRs in drug discovery and functional genomics Nat. Rev. Drug Discovery 1 2002 599-608
    • (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 599-608
    • Chalmers, D.T.1
  • 14
    • 0036449253 scopus 로고    scopus 로고
    • Functional assays for identifying ligands at orphan G protein coupled receptors
    • P.G. Szekeres Functional assays for identifying ligands at orphan G protein coupled receptors Recept. Channels 8 2002 297-308
    • (2002) Recept. Channels , vol.8 , pp. 297-308
    • Szekeres, P.G.1
  • 15
    • 4344577277 scopus 로고    scopus 로고
    • Identification of signal transduction pathways used by orphan G protein coupled receptors
    • S. Bresnick et al. Identification of signal transduction pathways used by orphan G protein coupled receptors Assay Drug Dev. 1 2003 239-249
    • (2003) Assay Drug Dev. , vol.1 , pp. 239-249
    • Bresnick, S.1
  • 16
    • 0038380750 scopus 로고    scopus 로고
    • High-content assays for ligand regulation of G-protein-coupled receptors
    • G. Milligan High-content assays for ligand regulation of G-protein-coupled receptors Drug Discovery Today 8 2003 579-585
    • (2003) Drug Discovery Today , vol.8 , pp. 579-585
    • Milligan, G.1
  • 17
    • 1542756081 scopus 로고    scopus 로고
    • Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation
    • S.S. Ferguson and M.G. Caron Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation Methods Mol. Biol. 237 2004 121-126
    • (2004) Methods Mol. Biol. , vol.237 , pp. 121-126
    • Ferguson, S.S.1    Caron, M.G.2
  • 18
    • 3042518074 scopus 로고    scopus 로고
    • CypHer 5: A generic approach for measuring the activation and trafficking of G protein coupled receptors
    • E.J. Adie et al. CypHer 5: A generic approach for measuring the activation and trafficking of G protein coupled receptors Assay Drug Dev. 1 2003 251-261
    • (2003) Assay Drug Dev. , vol.1 , pp. 251-261
    • Adie, E.J.1
  • 19
    • 0035283073 scopus 로고    scopus 로고
    • Orphan G-protein-coupled receptors and natural ligand discovery
    • A.D. Howard et al. Orphan G-protein-coupled receptors and natural ligand discovery Trends Pharmacol. Sci. 22 2001 132-140
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 132-140
    • Howard, A.D.1
  • 20
    • 0036243672 scopus 로고    scopus 로고
    • Novel G-protein-coupled receptor genes expressed in the brain: Continued discovery of important therapeutic targets
    • D.K. Lee et al. Novel G-protein-coupled receptor genes expressed in the brain: Continued discovery of important therapeutic targets Expert Opin. Ther. Targets 6 2002 185-202
    • (2002) Expert Opin. Ther. Targets , vol.6 , pp. 185-202
    • Lee, D.K.1
  • 21
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • N.E. Nilsson et al. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids Biochem. Biophys. Res. Commun. 303 2003 1047-1052
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1
  • 22
    • 10744224272 scopus 로고    scopus 로고
    • Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23
    • W. Meder et al. Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23 FEBS Lett. 555 2003 495-499
    • (2003) FEBS Lett. , vol.555 , pp. 495-499
    • Meder, W.1
  • 23
    • 12444335267 scopus 로고    scopus 로고
    • Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3
    • H-P. Lammerich et al. Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3 Br. J. Pharmacol. 138 2003 1431-1440
    • (2003) Br. J. Pharmacol. , vol.138 , pp. 1431-1440
    • Lammerich, H.-P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.