Continued discovery of ligands for G protein-coupled receptors

Life Sciences

Volumn 74, Issue 2-3, 2003, Pages 293-297

  Lee, Dennis K ^a   George, Susan R ^a,b   O'Dowd, Brian F ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c Medical Science Building ^*  (Canada)

Author keywords

Endogenous ligand; Orphan G protein coupled receptor; Reverse pharmacology

Indexed keywords

CALCIUM ION; CARBOXYLIC ACID DERIVATIVE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 43; G PROTEIN COUPLED RECEPTOR 7; G PROTEIN COUPLED RECEPTOR 8; LIGAND; LONG CHAIN FATTY ACID; NEUROPEPTIDE B; NEUROPEPTIDE B23; NEUROPEPTIDE B29; NEUROPEPTIDE W; NEUROPEPTIDE W23; NEUROPEPTIDE W30; PEPTIDE; PERTUSSIS TOXIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

CALCIUM SIGNALING; CONFERENCE PAPER; FOOD INTAKE; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; INJECTION; LOCOMOTION; NONHUMAN; OVARY; PLACENTA; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; SPINAL CORD; SPLEEN; SUBSTANTIA NIGRA; TESTIS; TISSUE DISTRIBUTION;

EID: 0242352645     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.09.016     Document Type: Conference Paper

References (20)

1. Bailey W.J., Vanti W.B., George S.R., Blevins R., Swaminathan S., Bonini J.A., Smith K.E., Weinshank R.L., O'Dowd B.F. Patent status of the therapeutically important G-protein-coupled receptors. Expert. Opin. Ther. Patents. 11:2001;1861-1887.
2. Baker J.R., Cardinal K., Bober C., Taylor M.M., Samson W.K. Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release. Endocrinology. 144:2003;2816-2821.
3. Brezillon S., Lannoy V., Franssen J.D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. J. Biol. Chem. 278:2003;776-783.
4. Briscoe C.P., Tadayyon M., Andrews J.L., Benson W.G., Chambers J.K., Eilert M.M., Ellis C., Elshourbagy N.A., Goetz A.S., Minnick D.T., Murdock P.R., Sauls H.R. Jr., Shabon U., Spinage L.D., Strum J.C., Szekeres P.G., Tan K.B., Way J.M., Ignar D.M., Wilson S., Muir A.I. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 278:2003;11303-11311.
5. Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J., Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C., Marshall F.H., Szekeres P.G., Wilson S., Ignar D.M., Foord S.M., Wise A., Dowell S.J. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 278:2003;11312-11319.
6. Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J. Biol. Chem. 277:2002;34010-34016.
7. Itoh Y., Kawamata Y., Harada M., Kobayashi M., Fujii R., Fukusumi S., Ogi K., Hosoya M., Tanaka Y., Uejima H., Tanaka H., Maruyama M., Satoh R., Okubo S., Kizawa H., Komatsu H., Matsumura F., Noguchi Y., Shinohara T., Hinuma S., Fujisawa Y., Fujino M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 422:2003;173-176.
8. Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., Shiao L.L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., Chateauneuf A., Coulombe N., Ng G., Johnson M.P., Tharian A., Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. J. Neurochem. 71:1998;2239-2251.
9. Kotarsky K., Nilsson N.E., Flodgren E., Owman C., Olde B. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem. Biophys. Res. Commun. 301:2003;406-410.
10. Lee D.K., George S.R., Evans J.F., Lynch K.R., O'Dowd B.F. Orphan G protein-coupled receptors in the CNS. Curr. Opin. Pharmacol. 1:2001;31-39.
11. Lee D.K., George S.R., O'Dowd B.F. Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets. Expert. Opin. Ther. Targets. 6:2002;185-202.
12. Lee D.K., Nguyen T., Porter C.A., Cheng R., George S.R., O'Dowd B.F. Two related G protein-coupled receptors: the distribution of GPR7 in rat brain and the absence of GPR8 in rodents. Brain Res. Mol. Brain Res. 71:1999;96-103.
13. Marchese A., George S.R., O'Dowd B.F. Cloning of G protein-coupled receptor genes: the use of homology screening and the polymerase chain reaction. Lynch K.R. Identification and Expression of G Protein-Coupled Receptors. 1998;1-26 Wiley-Liss, Inc. New York.
14. Nilsson N.E., Kotarsky K., Owman C., Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem. Biophys. Res. Commun. 303:2003;1047-1052.
15. O'Dowd B.F., Lee D.K., Huang W., Nguyen T., Cheng R., Liu Y., Wang B., Gershengorn M.C., George S.R. TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Mol. Endocrinol. 14:2000;183-193.
16. O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S., Marchese A., Zastawny R., Heng H.H., Tsui L.C., Shi X., Asa S., Puy L., George S.R. The cloning and chromosomal mapping of two novel human opioid-somatostatin- like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics. 28:1995;84-91.
17. Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F., O'Dowd B.F. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem. Biophys. Res. Commun. 239:1997;543-547.
18. Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J. Biol. Chem. 277:2002;35826-35832.
19. Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K., Yamanaka A., Williams S.C., Richardson J.A., Tsujino N., Garry M.G., Lerner M.R., King D.S., O'Dowd B.F., Sakurai T., Yanagisawa M. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U. S. A. 100:2003;6251-6256.
20. Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. The G protein-coupled receptor repertoires of human and mouse. Proc. Natl. Acad. Sci. U. S. A. 100:2003;4903-4908.