Targeting an mRNA for decapping: Displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs

Molecular Cell

Volumn 8, Issue 5, 2001, Pages 1075-1083

  Tharun, Sundaresan ^a   Parker, Roy ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHODIESTERASE I; RIBONUCLEOPROTEIN;

ARTICLE; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; DEANYLATION; EUKARYOTE; GENE TARGETING; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN INTERACTION; YEAST;

EUKARYOTA;

EID: 0035930337     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00395-1     Document Type: Article

References (32)

1. An essential component of the decapping enzyme required for normal rates of mRNA turnover
2. Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant
3. The two protein Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p
4. A Sm-like protein complex that participates in mRNA degradation
5. Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast
6. The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes
7. A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation
8. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif
9. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae
10. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins
11. Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae
12. The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3′ termini from partial degradation
13. Yeast cells lacking 5′ to 3′ exoribonuclease I contain mRNA species that are poly(A) deficient and partially lack the 5′ cap structure
14. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
15. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
16. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
17. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
18. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
19. Characterization of Sm-like proteins in yeast and their association with U6 snRNA
20. Mutations affecting stability and deadenylation of the yeast MFA2 transcript
21. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′-3′ digestion of the transcript
22. Turnover mechanisms of the stable yeast PGK1 mRNA
23. Starting at the beginning, middle, and end: Translation initiation in eukaryotes
24. Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae
25. mRNA decapping yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E
26. Analysis of mutations in the yeast mRNA decapping enzyme
27. Yeast Sm-like proteins function in mRNA decapping and decay
28. Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae
29. The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex
30. Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast
31. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans