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Volumn 78, Issue 5, 2004, Pages 2277-2287

Role for CCR5Δ32 Protein in Resistance to R5, R5X4, and X4 Human Immunodeficiency Virus Type 1 in Primary CD4+ Cells

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; COMPLEMENTARY DNA; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MUTANT PROTEIN; PHOSPHORUS 32; PHYTOHEMAGGLUTININ; RNA; RECOMBINANT DNA;

EID: 1242342131     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.5.2277-2287.2004     Document Type: Article
Times cited : (91)

References (50)
  • 1
    • 0011770673 scopus 로고    scopus 로고
    • Chemokine receptors: Emerging opportunities for new anti-HIV therapies
    • Agrawal, L., and G. Alkhatib. 2001. Chemokine receptors: emerging opportunities for new anti-HIV therapies. Expert Opin. Ther. Targets 5:303-326.
    • (2001) Expert Opin. Ther. Targets , vol.5 , pp. 303-326
    • Agrawal, L.1    Alkhatib, G.2
  • 2
    • 0023792844 scopus 로고
    • High-level eucaryotic in vivo expression of biologically active measles virus hemagglutinin by using an adenovirus type 5 helper-free vector system
    • Alkhatib, G., and D. J. Briedis. 1988. High-level eucaryotic in vivo expression of biologically active measles virus hemagglutinin by using an adenovirus type 5 helper-free vector system. J. Virol. 62:2718-2727.
    • (1988) J. Virol. , vol.62 , pp. 2718-2727
    • Alkhatib, G.1    Briedis, D.J.2
  • 3
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3    Feng, Y.4    Kennedy, P.E.5    Murphy, P.M.6    Berger, E.A.7
  • 4
    • 0030749666 scopus 로고    scopus 로고
    • HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: Independence from G protein signaling and importance of coreceptor down-modulation
    • Alkhatib, G., M. Locati, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1997. HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor down-modulation. Virology 234:340-348.
    • (1997) Virology , vol.234 , pp. 340-348
    • Alkhatib, G.1    Locati, M.2    Kennedy, P.E.3    Murphy, P.M.4    Berger, E.A.5
  • 5
    • 0023714870 scopus 로고
    • Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: Levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator codon
    • Alkhatib, G., B. Massie, and D. J. Briedis. 1988. Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator codon. J. Virol. 62:4059-4069.
    • (1988) J. Virol. , vol.62 , pp. 4059-4069
    • Alkhatib, G.1    Massie, B.2    Briedis, D.J.3
  • 6
    • 0025273116 scopus 로고
    • Intracellular processing, glycosylation, and cell-surface expression of the measles virus fusion protein (F) encoded by a recombinant adenovirus
    • Alkhatib, G., C. Richardson, and S. H. Shen. 1990. Intracellular processing, glycosylation, and cell-surface expression of the measles virus fusion protein (F) encoded by a recombinant adenovirus. Virology 175:262-270.
    • (1990) Virology , vol.175 , pp. 262-270
    • Alkhatib, G.1    Richardson, C.2    Shen, S.H.3
  • 7
    • 0031957171 scopus 로고    scopus 로고
    • Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates
    • Bazan, H. A., G. Alkhatib, C. C. Broder, and E. A. Berger. 1998. Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates. J. Virol. 72:4485-4491.
    • (1998) J. Virol. , vol.72 , pp. 4485-4491
    • Bazan, H.A.1    Alkhatib, G.2    Broder, C.C.3    Berger, E.A.4
  • 8
    • 0030712312 scopus 로고    scopus 로고
    • Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32
    • Benkirane, M., D. Y. Jin, R. F. Chun, R. A. Koup, and K. T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:30603-30606.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30603-30606
    • Benkirane, M.1    Jin, D.Y.2    Chun, R.F.3    Koup, R.A.4    Jeang, K.T.5
  • 9
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    • Berger, E. A., P. M. Murphy, and J. M. Farber. 1999. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17:657-700.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 657-700
    • Berger, E.A.1    Murphy, P.M.2    Farber, J.M.3
  • 10
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett, A. J., W. Haddara, L. Prevec, and F. L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91:8802-8806.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 11
    • 0031042433 scopus 로고    scopus 로고
    • The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
    • Bleul, C. C., L. Wu, J. A. Hoxie, T. A. Springer, and C. R. Mackay. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925-1930.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1925-1930
    • Bleul, C.C.1    Wu, L.2    Hoxie, J.A.3    Springer, T.A.4    Mackay, C.R.5
  • 12
    • 0033573545 scopus 로고    scopus 로고
    • Recombinant vaccinia viruses. Design, generation, and isolation
    • Broder, C. C., and P. L. Earl. 1999. Recombinant vaccinia viruses. Design, generation, and isolation. Mol. Biotechnol. 13:223-245.
    • (1999) Mol. Biotechnol. , vol.13 , pp. 223-245
    • Broder, C.C.1    Earl, P.L.2
  • 13
    • 0035861556 scopus 로고    scopus 로고
    • Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor
    • Chelli, M., and M. Alizon. 2001. Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor. J. Biol. Chem. 276:46975-46982.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46975-46982
    • Chelli, M.1    Alizon, M.2
  • 14
    • 0030963248 scopus 로고    scopus 로고
    • Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity
    • Chidiac, P., M. A. Green, A. B. Pawagi, and J. W. Wells. 1997. Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity. Biochemistry 36:7361-7379.
    • (1997) Biochemistry , vol.36 , pp. 7361-7379
    • Chidiac, P.1    Green, M.A.2    Pawagi, A.B.3    Wells, J.W.4
  • 15
    • 0029985197 scopus 로고    scopus 로고
    • + T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1
    • + T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1. J. Virol. 70:8758-8764.
    • (1996) J. Virol. , vol.70 , pp. 8758-8764
    • Connor, R.I.1    Paxton, W.A.2    Sheridan, K.E.3    Koup, R.A.4
  • 16
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
    • Erratum, 274:1069
    • Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, and S. J. O'Brien. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273:1856-1862. (Erratum, 274:1069.)
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3    Huttley, G.A.4    Smith, M.W.5    Allikmets, R.6    Goedert, J.J.7    Buchbinder, S.P.8    Vittinghoff, E.9    Gomperts, E.10    Donfield, S.11    Vlahov, D.12    Kaslow, R.13    Saah, A.14    Rinaldo, C.15    Detels, R.16    O'Brien, S.J.17
  • 17
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 18
    • 0025304162 scopus 로고
    • Adenoviruses as expression vectors and recombinant vaccines
    • Graham, F. L. 1990. Adenoviruses as expression vectors and recombinant vaccines. Trends Biotechnol. 8:85-87.
    • (1990) Trends Biotechnol. , vol.8 , pp. 85-87
    • Graham, F.L.1
  • 19
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-74.
    • (1977) J. Gen. Virol. , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 20
    • 0028007135 scopus 로고
    • A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells
    • Hirschberg, B. T., and M. I. Schimerlik. 1994. A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells. J. Biol. Chem. 269:26127-26135.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26127-26135
    • Hirschberg, B.T.1    Schimerlik, M.I.2
  • 22
    • 0033941573 scopus 로고    scopus 로고
    • Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
    • Kuhmann, S. E., E. J. Platt, S. L. Kozak, and D. Kabat. 2000. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J. Virol. 74:7005-7015.
    • (2000) J. Virol. , vol.74 , pp. 7005-7015
    • Kuhmann, S.E.1    Platt, E.J.2    Kozak, S.L.3    Kabat, D.4
  • 23
    • 0031851757 scopus 로고    scopus 로고
    • Influence of the CCR2-V641 polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4
    • Lee, B., B. J. Doranz, S. Rana, Y. Yi, M. Mellado, J. M. Frade, A. C. Martinez, S. J. O'Brien, M. Dean, R. G. Collman, and R. W. Doms. 1998. Influence of the CCR2-V641 polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J. Virol. 72:7450-7458.
    • (1998) J. Virol. , vol.72 , pp. 7450-7458
    • Lee, B.1    Doranz, B.J.2    Rana, S.3    Yi, Y.4    Mellado, M.5    Frade, J.M.6    Martinez, A.C.7    O'Brien, S.J.8    Dean, M.9    Collman, R.G.10    Doms, R.W.11
  • 24
    • 0033609149 scopus 로고    scopus 로고
    • Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendrilic cells, and differentially conditioned monocyte-derived macrophages
    • Lee, B., M. Sharron, L. J. Montaner, D. Weissman, and R. W. Doms. 1999. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendrilic cells, and differentially conditioned monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 96:5215-5220.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5215-5220
    • Lee, B.1    Sharron, M.2    Montaner, L.J.3    Weissman, D.4    Doms, R.W.5
  • 26
    • 0033057961 scopus 로고    scopus 로고
    • HIV-1 entry inhibitors: Evading the issue
    • Michael, N. L., and J. P. Moore. 1999. HIV-1 entry inhibitors: evading the issue. Nat. Med. 5:740-742.
    • (1999) Nat. Med. , vol.5 , pp. 740-742
    • Michael, N.L.1    Moore, J.P.2
  • 28
    • 0036121120 scopus 로고    scopus 로고
    • A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4
    • Naif, H. M., A. L. Cunningham, M. Alali, S. Li, N. Nasr, M. M. Buhler, D. Schols, E. de Clercq, and G. Stewart. 2002. A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4. J. Virol. 76:3114-3124.
    • (2002) J. Virol. , vol.76 , pp. 3114-3124
    • Naif, H.M.1    Cunningham, A.L.2    Alali, M.3    Li, S.4    Nasr, N.5    Buhler, M.M.6    Schols, D.7    De Clercq, E.8    Stewart, G.9
  • 29
    • 0028129959 scopus 로고
    • Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation
    • Nussbaum, O., C. C. Broder, and E. A. Berger. 1994. Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation. J. Virol. 68:5411-5422.
    • (1994) J. Virol. , vol.68 , pp. 5411-5422
    • Nussbaum, O.1    Broder, C.C.2    Berger, E.A.3
  • 30
    • 0033647217 scopus 로고    scopus 로고
    • The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
    • O'Brien, S. J., and J. P. Moore. 2000. The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol. Rev. 177:99-111.
    • (2000) Immunol. Rev. , vol.177 , pp. 99-111
    • O'Brien, S.J.1    Moore, J.P.2
  • 34
    • 0033567397 scopus 로고    scopus 로고
    • Novel method for evaluation of the oligomeric structure of membrane proteins
    • Ramjeesingh, M., L. J. Huan, E. Garami, and C. E. Bear. 1999. Novel method for evaluation of the oligomeric structure of membrane proteins. Biochem. J. 342:119-123.
    • (1999) Biochem. J. , vol.342 , pp. 119-123
    • Ramjeesingh, M.1    Huan, L.J.2    Garami, E.3    Bear, C.E.4
  • 40
    • 0030849537 scopus 로고    scopus 로고
    • Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2
    • Sol, N., F. Ferchal, J. Braun, O. Pleskoff, C. Treboute, I. Ansart, and M. Alizon. 1997. Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2. J. Virol. 71:8237-8244.
    • (1997) J. Virol. , vol.71 , pp. 8237-8244
    • Sol, N.1    Ferchal, F.2    Braun, J.3    Pleskoff, O.4    Treboute, C.5    Ansart, I.6    Alizon, M.7
  • 41
    • 0029794456 scopus 로고    scopus 로고
    • Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system
    • Sutton, R. E., and D. R. Littman. 1996. Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system. J. Virol. 70:7322-7326.
    • (1996) J. Virol. , vol.70 , pp. 7322-7326
    • Sutton, R.E.1    Littman, D.R.2
  • 42
    • 0037127299 scopus 로고    scopus 로고
    • Reduced cell surface expression of CCR5 in CCR5Δ32 heterozygotes is mediated by gene dosage rather than receptor sequestration
    • Venkatesan, S., A. Petrovic, D. I. Van Ryk, M. Locati, D. Weissman, and P. M. Murphy. 2002. Reduced cell surface expression of CCR5 in CCR5Δ32 heterozygotes is mediated by gene dosage rather than receptor sequestration. J. Biol. Chem. 277:2287-2301.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2287-2301
    • Venkatesan, S.1    Petrovic, A.2    Van Ryk, D.I.3    Locati, M.4    Weissman, D.5    Murphy, P.M.6
  • 43
    • 0032160522 scopus 로고    scopus 로고
    • CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates
    • Verani, A., E. Pesenti, S. Polo, E. Tresoldi, G. Scarlatti, P. Lusso, A. G. Siccardi, and D. Vercelli. 1998. CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates. J. Immunol. 161:2084-2088.
    • (1998) J. Immunol. , vol.161 , pp. 2084-2088
    • Verani, A.1    Pesenti, E.2    Polo, S.3    Tresoldi, E.4    Scarlatti, G.5    Lusso, P.6    Siccardi, A.G.7    Vercelli, D.8
  • 44
    • 0029083945 scopus 로고
    • Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors
    • Wreggett, K. A., and J. W. Wells. 1995. Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J. Biol. Chem. 270:22488-22499.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22488-22499
    • Wreggett, K.A.1    Wells, J.W.2
  • 46
    • 0033200006 scopus 로고    scopus 로고
    • Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion
    • Xiao, L., S. H. Weiss, S. H. Qari, D. Rudolph, C. Zhao, T. N. Denny, T. Hodge, and R. B. Lal. 1999. Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion. AIDS Res. Hum. Retrovir. 15:1201-1208.
    • (1999) AIDS Res. Hum. Retrovir. , vol.15 , pp. 1201-1208
    • Xiao, L.1    Weiss, S.H.2    Qari, S.H.3    Rudolph, D.4    Zhao, C.5    Denny, T.N.6    Hodge, T.7    Lal, R.B.8
  • 47
    • 0031985684 scopus 로고    scopus 로고
    • CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1
    • Yi, Y., S. Rana, J. D. Turner, N. Gaddis, and R. G. Collman. 1998. CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1. J. Virol. 72:772-777.
    • (1998) J. Virol. , vol.72 , pp. 772-777
    • Yi, Y.1    Rana, S.2    Turner, J.D.3    Gaddis, N.4    Collman, R.G.5
  • 48
    • 0032522661 scopus 로고    scopus 로고
    • Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor
    • Zhou, Y., T. Kurihara, R. P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr, and R. Bravo. 1998. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160:4018-4025.
    • (1998) J. Immunol. , vol.160 , pp. 4018-4025
    • Zhou, Y.1    Kurihara, T.2    Ryseck, R.P.3    Yang, Y.4    Ryan, C.5    Loy, J.6    Warr, G.7    Bravo, R.8
  • 49
    • 0032506160 scopus 로고    scopus 로고
    • Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function
    • Zhu, X., and J. Wess. 1998. Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37:15773-15784.
    • (1998) Biochemistry , vol.37 , pp. 15773-15784
    • Zhu, X.1    Wess, J.2


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