A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4

Journal of Virology

Volumn 76, Issue 7, 2002, Pages 3114-3124

  Naif, Hassan M ^a   Cunningham, Anthony L ^a   Alali, Mohammed ^a   Li, Shan ^a   Nasr, Najla ^a   Buhler, Marc M ^a   Schols, Dominique ^a   De Clercq, Erik ^a   Stewart, Graeme ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCLONAL ANTIBODY; RANTES; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CASE REPORT; CONTROLLED STUDY; DISEASE COURSE; DNA SEQUENCE; GENE MUTATION; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MALE; MONONUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SYNCYTIUM; T LYMPHOCYTE; VIRUS ISOLATION; VIRUS TRANSMISSION;

AMINO ACID SEQUENCE; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GENOTYPE; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HOMOZYGOTE; HUMANS; MACROPHAGES; MALE; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; RECEPTORS, CCR5; RECEPTORS, CXCR4; SEQUENCE ALIGNMENT; T-LYMPHOCYTES; TROPISM; VIRUS REPLICATION;

EID: 0036121120     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.7.3114-3124.2002     Document Type: Article

References (59)

1. Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates
2. A new SIV co-receptor, STRL33
3. CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
4. Homozygous Δ32 deletion of the CCR-5 chemokine receptor gene in an HIV-1 infected patient
5. A seven transmembrane domain receptor involved in fusion and entry of T-cell tropic HIV-1 strains
6. Structure-function studies of the HIV-1 coreceptors
7. HIV-1 infection in an individual homozygous for the CCR5 deletion allele
8. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
9. Orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1
10. The beta chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
11. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals
12. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
13. Genetic relationships determined by a DNA heteroduplex mobility assay: Analysis of HIV-1 env genes
14. Expression cloning of new receptors used by simian and human immunodeficiency viruses
15. Identification of a major co-receptor for primary isolates of HIV-1
16. A dual tropic isolate that uses fusin and the beta chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
17. + cells is mediated by the chemokine receptor CC-CKR-5
18. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus
19. Two orphan 7-transmembrane segment receptors which are expressed on CD4-positive cells support simian immunodeficiency virus infection
20. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
21. Replicative capacity, cytopathic effect and cell tropism of HIV
22. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immunodeficiency syndrome retrovirus
23. Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia
24. CCR3 and CCR5 are coreceptors for HIV-1 infection of microglia
25. The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains
26. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
27. Variations in CD4 expression by human monocytes and macrophages and their relationship to infection with the human immunodeficiency virus
28. Cutting edge: Dichotomous effects of β-chemokines on HIV replication in monocytes and monocyte-derived macrophages
29. An HIV-1-infected individual homozygous for the CCR-5 delta32 allele and the SDF-1 3′A allele
30. Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates
31. The Δ CCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe
32. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection
33. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32
34. Human immunodeficiency type 1 IIIB selceted for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: Separation of in vivo replication from macrophage tropism
35. Co-receptors for HIV-1 entry
36. Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages using twins
37. CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection
38. The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication
39. HIV-1 infection in a man homozygous for CCR5Δ32
40. Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors
41. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry
42. Role of CCR5 in infection of primary macrophages and lymphocytes by M-tropic strains of human immunodeficiency virus: Resistance to patient-derived and prototype isolates resulting from the CCR5 mutation
43. CD4-independent infection by HIV-2 (ROD/B): Use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry
44. Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses
45. Primer-directed enzyme amplification of DNA with a thermostable DNA polymerase
46. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
47. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
48. Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia
49. CXCR4 as a functional coreceptor for human immunodeficiency virus type 1 infection of primary macrophages
50. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression
51. Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes
52. Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection
53. HIV-1 infection in an individual homozygous for CCR5Δ32
54. Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates
55. CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates
56. Risk of human immunodeficiency virus (HIV-1) infection among laboratory workers
57. CCR5 levels and expression pattern correlate with infectability by macrophagetropic HIV-1. In vitro
58. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
59. Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro