High-valent intermediates of heme proteins and model compounds

Current Opinion in Chemical Biology

Volumn 5, Issue 6, 2001, Pages 724-735

  Harris, Danni L ^a  

^a MOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CATION; CYTOCHROME P450; HEMOPROTEIN; IRON; LIGAND; MANGANESE; PEROXIDASE; PORPHYRIN; PROTON;

BINDING SITE; CALCULATION; ELECTROCHEMISTRY; ENZYME MECHANISM; HYDROGEN BOND; POLARIZATION; PROTON TRANSPORT; REVIEW;

EID: 0035606245     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(01)00272-1     Document Type: Review

References (45)

1. Molecular oxygen in biological oxidation
2. Enzymology of oxygen
3. The structure and spin coupling of catalase compound I: A study of noncovalent effects
4. Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue
5. Proximal ligand effects on electronic structure and spectra of compound I of peroxidases
6. Medium polarization and hydrogen bonding effects on compound I of cytochrome P450: What kind of radical is it really?
7. The high-valent compound of cytochrome P450: The nature of the Fe-S bond and the role of the thiolate ligand as an internal electron donor
8. Chameleon states: High-valent metal-oxo species of cytochrome P450 and its ruthenium analog
9. Reaction mechanism of compound I formation in heme peroxidases: A density functional study
10. Cytochrome P450nor: A nitric oxide reductase - Structure, spectra, and mechanism
11. Proton transfer dynamics in the activation of cytochrome P450eryF
12. Hypersensitive radical probe studies of chloroperoxidase-catalyzed hydroxylation reactions
13. Chloroperoxidase-catalyzed asymmetric oxidations: Substrate specificity and mechanistic studies
14. Highly enantioselective epoxidation of disubstituted alkenes with hydrogen peroxide catalyzed by choroperoxidase
15. Unusual propargylic oxidations catalyzed by chloroperoxidase
16. 18O Studies of the peroxidase-catalyzed oxidation of N-methylcarbazole. Mechanisms of carbinolamine and carboxaldehyde formation
17. Enantioselective oxidations of sulfides catalyzed by chloroperoxidase
18. Cytochrome P-450 55A1 (P-450dNIR) acts as nitric oxide reductase employing NADH as the direct electron donor
19. Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism
20. Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin
21. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
22. Theoretical investigation of the proton assisted pathway to formation of cytochrome P450 compound I
23. A theoretical study of electronic factors affecting hydroxylation by model ferryl complexes of cytochrome P-450 and horseradish peroxidase
24. Density functional study on the electronic structures of model peroxidase compounds I and II
25. Identification of intermediates of the catalytic cycle of chloroperoxidase
26. Heme-containing oxygenases
27. Local density functional study of oxoiron (IV) porphyrin complexes and their one-electron oxidized derivatives: Axial ligand effects
28. Evidence for sulfur-based radicals in thiolate compound I intermediates
29. The experimentally elusive oxidant of cytochrome P450: A theoretical 'trapping' defining more closely the 'real' species
30. The catalytic pathway of cytochrome p450cam at atomic resolution
31. Calculation of the electronic structure and spectra of model cytochrome P450 compound I
32. Valence bond description of antiferromagnetic coupling in transition metal dimers
33. Imidazole-ligated compound I intermediates: The effects of hydrogen bonding
34. Bioinorganic spectroscopy
35. Saddle distortions of ferryl-porphyrin models for peroxidase compound I: A density functional study
36. A first-principles quantum chemical analysis of the factors controlling ruffling deformations of porphyrins: Insights from the molecular structures and potential energy surfaces of silicon, phosphorus, germanium, and arsenic porphyrins and of a peroxidase compound I model
37. Investigation of the proton-assisted pathway to formation of the catalytically active, ferryl species of P450s by molecular dynamics studies of P450eryF
38. Structure and spectra of ferrous dioxygen and reduced ferrous dioxygen model cytochrome P450
39. High-valent transition metal centers and noninnocent ligands in metalloporphyrins and related molecules: A broad overview based on quantum chemical calculations
40. Electrochemical and electronic absorption spectroscopic studies of substitutent effects in iron (IV) and manganese (IV) corroles. Do the compounds feature high-valent metal centers or noninnicent corrole ligands? Implications for peroxidase compound I and II intermediates
41. What is the difference between manganese porphyrin and corrole analogues of cytochrome P450's compound I?
42. High-valent corrole metal complexes