The presence of astrocytes enhances beta amyloid-induced neurotoxicity in hippocampal cell cultures

Journal of Physiology Paris

Volumn 96, Issue 3-4, 2002, Pages 313-316

  Domenici, M R ^a   Paradisi, S ^a   Sacchetti, B ^a   Gaudi, S ^a   Balduzzi, M ^b   Bernardo, A ^a   Ajmone Cat, M A ^a   Minghetti, L ^a   Malchiodi Albedi, F ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ENEA   (Italy)

Author keywords

Amyloid; Alzheimer's disease; Astrocytes; Neurotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; CYTARABINE; DIAMINOBENZIDINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL INTERACTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EVALUATION; GLIA; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTHESIS; IN VITRO STUDY; MIXED CELL CULTURE; MODEL; NERVE CELL; NERVE DEGENERATION; NERVE INJURY; NEUROTOXICITY; NONHUMAN; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; ASTROCYTES; CELL COMMUNICATION; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; HIPPOCAMPUS; NEURONS; RATS; RATS, WISTAR;

EID: 0036556422     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(02)00021-9     Document Type: Article

References (12)

1. C. Behl, J. Davis, R. Lesley, D. Schubert, Hydrogen peroxide mediates amyloid beta protein toxicity, Cell 77 (1994) 817-827.
2. J. Busciglio, J. Yeh, B.A. Yankner, beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins, J. Neurochem. 61 (1993) 1565-1568.
3. V.L. Dowson, Nitric Oxide: role in neurotoxicity, Clin. Exp. Pharmacol. Physiol. 22 (1995) 305-308.
4. G. Forloni, R. Chiesa, S. Smiroldo, S. Versa, M. Salmona, F. Tagliavini, N. Angeretti, Apoptosis mediated neurotoxicity induced by chronic application of beta-amyloid fragment 25-35, Neuroreport 4 (1993) 523-526.
5. M.E. Hatten, N. Heintz, Mechanisms of neural pattern and specification in the developing cerebellum, Annu. Rev. Neurosci. 18, (1995) 385-408.
6. J. Hu, K.T. Akama, G.A. Krafft, B.A. Chromy, L.J. Van Eldik, Amyliod-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release, Brain Res. 785 (1998) 195-206.
7. Q.Y. Liu, A.E. Schaffner, Y.H. Chang, K. Vaszil, J.L. Barker, Astrocytes regulate amino acid receptor current densities in embryonic rat hippocampal neurons, J. Neurobiol. 33 (1997) 848-864.
8. F. Malchiodi-Albedi, M.R. Domonici, S. Paradisi, A. Bernardo, M.A. Ajmone-Cat, L. Minghetti, Astrocytes contribute to neuronal impairment in βA toxicity increasing apoptosis in rat hippocampal neurons, Glia 34 (2001) 68-72.
9. L.A. Peña, C.W. Brecher, D.R. Marshak, β-amyloid regulates gene expression of glial trophic substances S-100β in C6 glioma and primary astrocyte cultures, Mol. Brain. Res. 34 (1995) 118-126.
10. C.J. Pike, B.J. Cummings, C.W. Cotman, beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology, Neuroreport 3 (1992) 769-772.
11. P. Shubert, T. Ogata, C. Marchini, S. Ferroni, Glia-related pathomechanisms in Alzheimer's disease: a therapeutic target?, Mech. Ageing Dev. 123 (2001) 47-57.
12. B.A. Yankner, L.R. Dawes, S. Fisher, L. Villa-Komaroff, M.L. Oster-Granite, R.L. Neve, Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease, Science 245 (1989) 417-420.