Chapter 27. Eosinophils in repair and remodelling

Clinical and Experimental Allergy Reviews

Volumn 4, Issue SUPPL. 2, 2004, Pages 229-236

  Kay, A B ^a   Flood Page, P ^a   Menzies Gow, A ^a   Robinson, D ^a   Phipps, S ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Eosinophil; Remodelling; Repair; TGF

Indexed keywords

ALLERGEN; INTERLEUKIN 13; INTERLEUKIN 5 ANTIBODY; MATRIX PROTEIN; MEPOLIZUMAB; PROCOLLAGEN; TENASCIN; TRANSFORMING GROWTH FACTOR BETA1;

ALLERGENICITY; ALLERGIC ASTHMA; ALLERGY; BASEMENT MEMBRANE; CELL ACTIVATION; CELL REGENERATION; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; EDEMA; EOSINOPHIL; ERYTHEMA; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LYMPHOCYTIC INFILTRATION; MYOFIBROBLAST; PRIORITY JOURNAL; SKIN BIOPSY; SKIN INDURATION; TIME;

EID: 11844294689     PISSN: 14729725     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-9725.2004.00059.x     Document Type: Conference Paper

References (66)

1. Wardlaw AJ, Moqbel R, Kay AB. Eosinophils: biology and role in disease. Adv Immunol 1995; 60:151-266.
2. Todd R, Donoff BR, Chiang T et al. The eosinophil as a cellular source of transforming growth factor alpha in healing cutaneous wounds. Am J Pathol 1991; 138:1307-13.
3. Wong DT, Donoff RB, Yang J et al. Sequential expression of transforming growth factors alpha and beta 1 by eosinophils during cutaneous wound healing in the hamster. Am J Pathol 1993; 143:130-42.
4. Noguchi H, Kephart GM, Colby TV, Gleich GJ. Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am J Pathol 1992; 140:521-8.
5. Shock A, Rabe KF, Dent G et al. Eosinophils adhere to and stimulate replication of lung fibroblasts 'in vitro'. Clin Exp Immunol 1991; 86:185-90.
6. Birkland TP, Cheavens MD, Pincus SH. Human eosinophils stimulate DNA synthesis and matrix production in dermal fibroblasts. Arch Dermatol Res 1994; 286:312-8.
7. Levi-Schaffer F, Garbuzenko E, Rubin A et al. Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta). Proc Natl Acad Sci USA 1999; 96:9660-5.
8. Doucet C, Brouty-Boye D, Pottin-Clemenceau C, Canonica GW, Jasmin C, Azzarone B. Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Invest 1998; 101:2129-39.
9. Teran LM, Mochizuki M, Bartels J et al. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol 1999; 20:777-86.
10. Liu X, Kohyama T, Wang H et al. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol 2002; 282:L1049-L1056.
11. Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103:779-88.
12. Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999; 104:777-85.
13. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001; 107:295-301.
14. Minshall E, Chakir J, Laviolette M et al. IL-11 expression is increased in severe asthma: association with epithelial cells and eosinophils. J Allergy Clin Immunol 2000; 105:232-8.
15. Molet S, Hamid Q, Davoine F et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001; 108:430-8.
16. Solomon A, Aloe L, Pe'er J et al. Nerve growth factor is preformed in and activates human peripheral blood eosinophils. J Allergy Clin Immunol 1998; 102:454-60.
17. Elovic A, Wong DT, Weller PF, Matossian K, Galli SJ. Expression of transforming growth factors-alpha and beta 1 messenger RNA and product by eosinophils in nasal polyps. J Allergy Clin Immunol 1994; 93:864-9.
18. Horiuchi T, Weller PF. Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5. Am J Respir Cell Mol Biol 1997; 17:70-7.
19. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodelling. Am J Respir Crit Care Med 2000; 161:1720-45.
20. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989; 1:520-4.
21. Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989; 140:1745-53.
22. Wilson JW, Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin Exp Allergy 1997; 27:363-71.
23. Jeffery PK, Godfrey RW, Adelroth E, Nelson F, Rogers A, Johansson SA. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 1992; 145:890-9.
24. Laitinen A, Altraja A, Kampe M, Linden M, Virtanen I, Laitinen LA. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med 1997; 156:951-8.
25. Huang J, Olivenstein R, Taha R, Hamid Q, Ludwig M. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 1999; 160:725-9.
26. Murphy-Ullrich JE. The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state? J Clin Invest 2001; 107:785-90.
27. Anwar AR, Moqbel R, Walsh GM, Kay AB, Wardlaw AJ. Adhesion to fibronectin prolongs eosinophil survival. J Exp Med 1993; 177:839-43.
28. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 1993; 148:720-6.
29. Ordonez CL, Khashayar R, Wong HH et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001; 163:517-23.
30. Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997; 156:229-33.
31. Gizycki MJ, Adelroth E, Rogers AV, O'Byrne PM, Jeffery PK. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997; 16:664-73.
32. Ohno I, Lea RG, Flanders KC et al. Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1). J Clin Invest 1992; 89:1662-8.
33. Ohno I, Nitta Y, Yamauchi K et al. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 1996; 15:404-9.
34. Minshall EM, Leung DY, Martin RJ et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997; 17:326-33.
35. Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990; 63:21-9.
36. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122:103-11.
37. Elovic AE, Ohyama H, Sauty A et al. IL-4-dependent regulation of TGF-alpha and TGF-beta1 expression in human eosinophils. J Immunol 1998; 160:6121-7.
38. Lee CG, Homer RJ, Zhu Z et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001; 194:809-21.
39. Ying S, Meng Q, Barata LT, Robinson DS, Durham SR, Kay AB. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Immunol 1997; 158:5050-7.
40. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990; 3:507-11.
41. Phipps S, Kay AB. Eosinophil-induced myofibroblast differentiation. J Allergy Clin Immunol 2001; 107:5323 [Abstract].
42. Ruegg CR, Chiquet-Ehrismann R, Alkan SS. Tenascin, an extracellular matrix protein, exerts immunomodulatory activities. Proc Natl Acad Sci USA 1989; 86:7437-41.
43. Erickson HP, Bourdon MA. Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. Annu Rev Cell Biol 1989; 5:71-92.
44. Treasurywala S, Berens ME. Migration arrest in glioma cells is dependent on the alphav integrin subunit. Glia 1998; 24:236-43.
45. Koyama Y, Kusubata M, Yoshiki A et al. Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. J Invest Dermatol 1998; 111:930-5.
46. Ying S, Robinson DS, Meng Q et al. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 1999; 163:3976-84.
47. Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood 1992; 79:3101-9.
48. Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
49. Flood-Page P, Menzies-Gow A, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Resp Crit Care Med 2003; 167:199-204.
50. Phipps S, Ying S, Wangoo A, Ong YE, Levi-Schaffer F, Kay AB. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodelling in human atopic skin. J Immunol 2002; 169:4604-12.
51. Phipps S, Flood-Page P, Menzies-Gow A, Ong YE, Kay AB. Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin. J Invest Dermatol 2004; 122:1406-1412.
52. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, Barnes N, Robinson DS, Kay AB. Anti-IL-5 treatment (mepolizumab) reduces deposition of extracellular matrix proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics: evidence for a role for eosinophils in airways remodeling. J Clin Invest 2003; 112:1029-1036.
53. Trifilieff A, Fujitani Y, Coyle AJ, Kopf M, Bertrand C. IL-5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation. Clin Exp Allergy 2001; 31:934-42.
54. Blyth DI, Wharton TF, Pedrick MS, Savage TJ, Sanjar S. Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-interleukin-5 antibody. Am J Respir Cell Mol Biol 2000; 23:241-6.
55. Trigg CJ, Manolitsas ND, Wang J et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994; 150:17-22.
56. Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999; 159:1043-51.
57. Ward C, Pais M, Bish R et al. Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002; 57:309-16.
58. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 145:1251-8.
59. Hoshino M, Nakamura Y, Sim J, Shimojo J, Isogai S. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol 1998; 102:783-8.
60. Vignola AM, Chanez P, Chiappara G et al. Release of transforming growth factor-beta (TGF-beta) and fibronectin by alveolar macrophages in airway diseases. Clin Exp Immunol 1996; 106:114-9.
61. Handzel ZT, Busse WW, Sedgwick JB et al. Eosinophils bind rhinovirus and activate virus-specific T cells. J Immunol 1998; 160:1279-84.
62. Nishinakamura R, Miyajima A, Mee PJ, Tybulewicz VL, Murray R. Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Blood 1996; 88:2458-64.
63. Foster PS, Mould AW, Yang M et al. Elemental signals regulating eosinophil accumulation in the lung. Immunol Rev 2001; 179:173-81.
64. Olivieri D, Chetta A, Del Donno M et al. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodelling in mild asthma: a placebo-controlled study. Am J Respir Crit Care Med 1997; 155:1864-71.
65. Hoshino M, Nakamura Y, Sim JJ et al. Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF)-I expression in bronchial asthma. Clin Exp Allergy 1998; 28:568-77.
66. Saetta M, Maestrelli P, Turato G et al. Airway wall remodelling after cessation of exposure to isocyanates in sensitized asthmatic subjects. Am J Respir Crit Care Med 1995; 151:489-94.