Eosinophils bind rhinovirus and activate virus-specific T cells

Journal of Immunology

Volumn 160, Issue 3, 1998, Pages 1279-1284

  Handzel, Zeev T ^a,c   Busse, William W ^a   Sedgwick, Julie B ^a   Vrtis, Rose ^a   Lee, Wai Ming ^b   Kelly, E A B ^a   Gern, James E ^a,a,d  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c KAPLAN HOSPITAL   (Israel)

^d University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; CD69 ANTIGEN; CELL SURFACE MARKER; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; SUPEROXIDE; VIRUS ANTIGEN;

ADULT; ALLERGIC ASTHMA; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DEGRANULATION; EOSINOPHIL; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS; IMMUNE RESPONSE; INTERFERON PRODUCTION; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGEN PRESENTATION; ANTIGENS, VIRAL; CELL ADHESION; CLONE CELLS; EOSINOPHILS; EPITOPES, T-LYMPHOCYTE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE ACTIVATION; MIDDLE AGED; RHINOVIRUS; SUPEROXIDES; T-LYMPHOCYTE SUBSETS; VIRUS ACTIVATION;

EID: 0031889924     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Nicholson, K. G., J. Kent, and D. C. Ireland. 1993. Respiratory viruses and exacerbations of asthma in adults. BMJ 307:982.
2. Pattemore, P. K., S. L. Johnston, and P. G. Bardin. 1992. Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin. Exp. Allergy 22:325.
3. Duff, A. L., E. S. Pomeranz, L. E. Gelber, H. W. Price, H. Farris, F. G. Hayden, T. A. E. Platts-Mills, and P. W. Heymann. 1993. Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens. Pediatrics 92:535.
4. Busse, W. W., and J. E. Gern. 1997. Viruses in asthma. J. Allergy Clin. Immunol. 100:147.
5. Johnston S. L., P. K. Pattemore, G. Sanderson, S. Smith, F. Lampe, L. Josephs, P. Symington, S. O'Toole, S. H. Myint, D. A. Tyrrell, and S. T. Holgate. 1995. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 310:1225.
6. Calhoun, W. J., E. C. Dick, L. B. Schwartz, and W. W. Busse. 1994. A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J. Clin. Invest. 94:2200.
7. Fraenkel, D. J., P. G. Bardin, G. Sanderson, F. Lampe, S. L. Johnston, and S. T. Holgate. 1995. Lower airway inflammation during rhinovirus colds in normal and in asthmatic subjects. Am. J. Respir. Crit. Care Med. 151:879.
8. Trigg, C. J., K. G. Nicholson, J. H. Wang, D. C. Ireland, S. Jordan, J. M. Duddle, S. Hamilton, and R. J. Daview. 1996. Bronchial inflammation and the common cold: a comparison of atopic and non-atopic individuals. Clin. Exp. Allergy 26: 665.
9. Heymann, P. W., G. P. Rakes, A. D. Hogan, J. M. Ingram, G. E. Hoover, and T. A. Platts-Mills. 1995. Assessment of eosinophils, viruses and IgE antibody in wheezing infants and children. Int. Arch. Allergy Immunol. 107:380.
10. Garofalo, R., J. L. L. Kimpen, R. C. Welliver, and P. L. Ogra. 1992. Eosmophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. J. Pediatr. 120:28.
11. Seminario, M., D. Squillace, P. G. Bardin, D. J. Fraenkel, G. J. Gleich, and S. L. Johnston. 1995. Increased levels of eosinophil major basic protein in nasal secretions in rhinovirus infection. J. Allergy Clin. Immunol. 95:259 (Abstr.).
12. Gern, J. E., E. C. Dick, W. M. Lee, S. Murray, K. Meyer, Z. T. Handzel, and W. W. Busse. 1996. Rhinovirus enters but does not replicate inside monocytes and airway macrophages. J. Immunol. 156:621.
13. Hansel, T. T., I. J. M. de Vries, T. Iff, S. Rihs, M. Wandzilak, S. Betz, K. Blaser, and C. Walker. 1991. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods 145:105.
14. Gern, J. E., E. C. Dick, E. A. B. Kelly, R. Vrtis, and B. Klein. 1997. Rhinovirus-specific T cells recognize both shared and serotype-restricted viral epitopes. J. Infect. Dis. 175:1108.
15. Gern, J. E., R. Vrtis, E. A. B. Kelly, E. C. Dick, and W. W. Busse. 1996. Rhinovirus produces nonspecific activation of lymphocytes through a monocyte-dependent mechanism. J. Immunol. 157:1605.
16. Sedgwick, J. B., K. M. Geiger, and W. W. Busse. 1990. Superoxide generation by hypodense eosinophils from patients with asthma. Am. Rev. Respir. Dis. 142: 120.
17. Hansel, T. T., I. J. M. Devries, J. M. Carballido, R. K. Braun, N. Carballidoperrig, S. Rihs, K. Blaser, and C. Walker. 1992. Induction and function of eosinophil intercellular adhesion molecule-1 and HLA-DR. J. Immunol. 149:2130.
18. Sedgwick, J. B., S. F. Quan, W. J. Calhoun, and W. W. Busse. 1995. Effect of interleukin-5 and granulocyte-macrophage colony stimulating factor on in vitro eosinophil function: comparison with airway eosinophils. J. Allergy Clin. Immunol. 96:375.
19. Mengelers, H. J., T. Maikoe, L. Brinkman, B. Hooibrink, J. W. J. Lammers, and L. Koenderman. 1994. Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics. Am. J. Respir. Crit. Care Med. 149:345.
20. Del Pozo, V., B. Deandres, E. Martin, B. Cardaba, J. C. Fernandez, S. Gallardo, P. Tramon, F. Leyva-Cobian, P. Palomino, and C. Lahoz. 1992. Eosinophils as antigen presenting cells: activation of T cell clones and T cell hybridomas by eosinophils after antigen processing. Eur. J. Immunol. 22:1919
21. Weller, P. F., T. H. Rand, T. Barrett, A. Elovic, D. T. W. Wong, and R. W. Finberg. 1993. Accessory cell function of human eosinophils. J. Immunol. 150:2554.
22. + T-cell proliferation. Immunology 81:584.
23. Gern, J. E., and W. W. Busse. 1996. Role of T cells in virus-induced asthma. In The Genetics of Asthma. S. B. Liggett and D. A. Meyers, eds. Marcel Dekker, New York, p. 39.
24. Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. 1986. Induction by IL 1 and interferon-γ-tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245.
25. Look, D. C., S. R. Rapp, B. T. Keller, and M. J. Holtzman. 1992. Selective induction of intercellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells. Am. J. Physiol. 263:L79.
26. + T-cell responses. Immunol. Today 17:410.
27. Mengelers, H. J. J., T. Maikoe, J. A. M. Raaijmakers, J. W. J. Lammers, and L. Koenderman. 1995. Cognate interaction between human lymphocytes and eosinophils is mediated by beta 2-integrins and very late antigen-4. J. Lab. Clin. Med. 126:261.
28. Strickland, D. H., U. R. Kees, and P. G. Holt. 1994. Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation. Eur. Respir. J. 7:2124.
29. Busse, W. W., M. Nagata, and J. B. Sedgwick. 1996. Characteristics of airway eosinophils. Eur. Respir. J. 9:5132.
30. Teran, L. M., S. L. Johnston, and S. T. Holgate. 1995. Immunoreactive RANTES and MIP-1α are increased in the nasal aspirates of children with virus-associated asthma. Am. J. Respir. Crit. Care Med. 151:A385 (Abstr.).
31. Subauste, M. C., D. B. Jacoby, S. M. Richards, and D. Proud. 1995. Infection of a human respiratory epithelial cell line with rhinovirus: induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J. Clin. Invest. 96:549.
32. Kameyoshi, Y., A. Dorschner, A. I. Mallet, E. Christophers, and J. M. Schroder. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176:587.
33. Zhang, L., A. E. Redington, and S. T. Holgate. 1994. RANTES: a novel mediator of allergic inflammation? Clin. Exp. Allergy 24:899.
34. -) generation and degranulation. Am. J. Resp. Crit. Care Med. 151:A240 (Abstr.).
35. Lopez, A. F., D. J. Williamson, J. R. Gamble, C. G. Begley, J. M. Harlan, S. J. Klebanoff, A. Waltersdorph, G. Wong, S. C. Clark, and M. A. Vadas. 1986. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. J. Clin. Invest. 78:1220.