Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFκB, c-fos/c-jun, and p53 proteins

Molecular Carcinogenesis

Volumn 22, Issue 4, 1998, Pages 235-246

  Liu, Guang Yaw ^a   Frank, Norbert ^b   Bartsch, Helmut ^b   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

AP 1; Apoptosis; Dithiocarbamate; G1 arrest; NF B; P53; Thiuramdisulfide

Indexed keywords

DIETHYLDITHIOCARBAMIC ACID; DISULFIDE; DISULFIRAM;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE INDUCTION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALCOHOL DETERRENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISULFIRAM; DITIOCARB; G1 PHASE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NF-KAPPA B; OXIDATION-REDUCTION; PROLINE; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; THIOCARBAMATES; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0031855760     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199808)22:4<235::AID-MC5>3.0.CO;2-I     Document Type: Article

References (53)

1. Abanobi SE, Popp JA, Chang SK, et al. Inhibition of dimethylnitrosamine-induced strand breaks in liver DNA and liver cell necrosis by diethyldithiocarbamate. J Natl Cancer Inst 58:263-271, 1977.
2. Hadjiolov D, Frank N, Mundt D, et al. Effects of disulfiram on metabolism of nitrosodiethylamine during liver carcinogenesis. J Cancer Res Clin Oncol 108:281-285, 1984.
3. Gringeri A, Keng PC, Borch RF. Diethyldithiocarbamate inhibition of murine bone marrow toxicity caused by cisdiammine-dichloroplatinum (II) or diammine (1, 1-cyclobutanedicarboxylato) platinum (II). Cancer Res 48:5708-5712, 1988.
4. Pannacciulli IM, Lerza RA, Bogliolo GV, et al. Effect of diethyl-dithiocarbamate on toxicity of doxorubicin, cyclophosphamide and cisdiamminedichloroplatinum (II) on mice haemopoietic progenitor cells. Br J Cancer 59:371-374, 1989.
5. Frank N, Wiessler M, Hadjiolov D. Influence of disulfiram on the metabolism of N-nitrosodiethylamine. IARC Sci Publ 57:519-523, 1984.
6. Schweinsberg F, Bu̇rkle V. Wirkung von Disulfiram auf die Toxizität und Carcinogenitet von N-Methyl-N-nitrosobenzylamin bei Ratten. J Cancer Res Clin Oncol 102:43-47, 1981.
7. Schweinsberg F, Danecki S, Grotzke J, et al. Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methylbenzylamine-induced carcinogenesis in rats. J Cancer Res Clin Oncol 112:75-80, 1986.
8. Lijinsky W, Reuber MD. Tumor induced in Fischer F344 rats by the feeding of disulfiram together with sodium nitrite. Food Chem Toxicol 18:85-87, 1980.
9. Hadjiolov D, Frank N, Moog C. Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis. J Cancer Res Clin Oncol 118:401-404, 1992.
10. Frank N, Christmann A, Frei E. Compaction studies on the pharmacokinetics of hydrophilic prolinedithiocarbamate, sarcosinedithiocarbamate and the less hydrophilic diethyldithiocarbamate. Toxicology 95:113-122, 1995.
11. Guillaumin JM, Lepape A, Renoux G. Fate and distribution of radioactive sodium diethyldithiocarbamate (imuthiol) in the mouse. Int J Immunopharmacol 8:859-865, 1986.
12. Holm IE, Andreasen A, Danscher G. Densitometric analysis of the local bleaching of the Neo-Timm staining pattern following intrahippocampal injection of diethyldithiocarbamate. Histochem J 23:63-68, 1991.
13. Frank N, Bertram B, Scherf HR, et al. Influence of ditniocarbamates on the metabolism and toxicity of N-nitrosodimethylamine in rats. Carcinogenesis 11:199-203, 1990.
14. Osswald H, Frank N. Sarcosine-and proline-dithiocarbamate pretreatment increases the therapeutic efficacy of doxorubicin, methotrexate, teniposide, mitoxantrone or cyclohexylchloroethylnitrosourea in leukemia L1210. J Cancer Res Clin Oncol 116:448-452, 1990.
15. Williams EE. Effects of alcohol on workers with carbon disulfide. JAMA 109:1472-1473, 1937.
16. Kitson TM. Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram. Biochem J 213:551-554, 1983.
17. Marchner H, Tottmar O. A comparative study on the effects of disulfiram, cyanamide and 1-aminocyclopropanol on the acetaldehyde metabolism in rats. Acta Pharmacol Toxicol 43:219-232, 1978.
18. Eneanya DI, Bianchine JR, Duran DO, et al. The actions and metabolic fate of disulfiram. Annu Rev Pharmacol Toxicol 21:575-596, 1981.
19. Goldstein M, Anagnoste B, Lauber E, et al. Inhibition of dopamine-β-hydroxylase by disulfiram. Life Sci 3:763-767, 1964.
20. Guan RJ, Moss SF, Arber N, et al. 30 kDa phosphorylation form of Bcl-2 protein in human colon. Oncogene 12:2605-2609, 1996.
21. Chang TC, Huang SM, Huang TM, et al. Human placental alkaline phosphatase: An improved purification procedure and kinetic studies. Eur J Biochem 209:241-247, 1992.
22. Xiong Y, Zhang H, Beach D. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7:1572-1583, 1993.
23. Rothstein JD, Bristol LA, Hosler B, et al. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc Natl Acad Sci USA 91:4155-4159, 1994.
24. 1 arrest in human cancer cells. Cancer Res 55-5187-5190, 1995.
25. De Sondt HL, Rosenblatt J, Jancarik J, et al. Crystal structure of cyclin-dependent kinase 2. Nature 363:595-602, 1993.
26. Morgan DO, De Bondt HL. Protein kinase regulation: Insights from crystal structure analysis. Curr Opin Cell Biol 6:239-246, 1994.
27. Won KA, Reed S. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J 15:4182-4193, 1996.
28. Clurman BE, Sheaff RJ, Thress K, et al. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 10:1979-1990, 1996.
29. Polyak K, Xia Y, Zweier JL, et al. A model for p53-induced apoptosis. Nature 389:300-305, 1997.
30. Ducommun B, Brambilla P, Felix MA, et al. cdc2 phosphorylation is required for its interaction with cyclin. EMBO J 10(11):3310-3319, 1991.
31. Desai D, Wessling HC, Fisher RP, et al. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol 15:345-350, 1995.
32. Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382(6591):511-517, 1996.
33. Atherton-Fessler S, Parker LL, Geahlen RL, et al. Mechanisms of p34cdc2 regulation. Mol Cell Biol 13:1675-1685, 1993.
34. Polyak K, Lee MH, Erdjument-Bromage H, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular artimitogenic signals. Cell 78(1):59-66, 1994.
35. Dulic V, Kaufmann WK, Wilson SJ, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76(6):1013-1023, 1994.
36. INK4/CDKN2 and p53 genes cooperated to induce apoptotic tumor cell death. Nature Med 3:313-319, 1997.
37. Johnson TM, Yu ZX, Ferrans VJ, et al. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93:11848-11852, 1996.
38. Deng C, Zhang P, Harper JW, et al. Mice lacking p21/WAF1/CIP1 undergo normal development, but are defective in G1 checkpoint control. Cell 82(4):675-684, 1995.
39. White E. Life, death, and the pursuit of apoptosis. Genes Dev 10(1):1-15, 1996.
40. Angel P, Karin M. The role of Jun, Fos and AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129-157, 1991.
41. Morgan JL, Curran T. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 14:421-451, 1991.
42. Devary Y, Gottlieb RA, Lan LF, et al. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11:2804-2811, 1991.
43. Sherman ML, Datta R, Hallahan DE, et al. Ionizing radiation regulates expression of the c-jun proto-oncogene. Proc Natl Acad Sci USA 87:5663-5666, 1990.
44. Karin M, Liu ZG, Zandi E. AP-1 function and regulation. Curr Opin Ceil Biol 9:240-246, 1997.
45. Siebenlist U. NFκB/lκB proteins. Their role in cell growth, differentiation and development. Madrid, Spain, July 7-10, 1996. Biochim Biophys Acta 1332:R7-R13, 1997.
46. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annual Review of Cell Biology 10:405-455, 1994.
47. Baeuerle P, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141-179, 1994.
48. Verma IM, Stevenson JK, Schwarz EM, et al. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation. Genes Dev 9:2723-2735, 1995.
49. Finco T, Baldwin A. Mechanistic aspects of NF-kappa B regulation: The emerging role of phosphorylation and proteolysis. Immunity 3:263-272, 1995.
50. Baldwin AS-Jr. The NF-kappa B and I kappa B proteins, new discoveries and insights. Annu Rev Immunol 14:649-683, 1996.
51. Grimm S, Bauer M, Baeuerle PA, et al. Bcl-2 down-regulates the activity of transcription factor NFκB induced upon apoptosis. J Cell Biol 134:13-23, 1996.
52. Schreck R, Meier B, Mannel DN, et al. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 175:1181-1194, 1992.
53. Abbadie C, Kabrun N, Bouali F, et al. High levels of c-rel, expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro. Cell 75:899-912, 1993.