LFA-1 integrin and the microtubular cytoskeleton are involved in the Ca2+-mediated regulation of the activity of the tyrosine kinase PYK2 in t cells

Journal of Leukocyte Biology

Volumn 71, Issue 3, 2002, Pages 520-530

  Rodríguez Fernández, José Luis ^a   Sánchez Martín, Lorena ^a   De Frutos, Cristina Alvarez ^a   Sancho, David ^b   Robinson, Martyn ^c   Sánchez Madrid, Francisco ^b   Cabañas, Carlos ^a,d  

^a SCHOOL OF MEDICINE   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c UCB PHARMA   (Belgium)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adhesion molecules; Protein kinases; Signal transduction; T lymphocytes

Indexed keywords

CALCIMYCIN; CALCIUM CHELATING AGENT; CALCIUM ION; EGTAZIC ACID; FOCAL ADHESION KINASE 2; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; IONOMYCIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; THAPSIGARGIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM METABOLISM; CALCIUM MOBILIZATION; CROSS LINKING; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; T LYMPHOBLAST;

CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; CYTOSKELETON; FOCAL ADHESION KINASE 2; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICROTUBULES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036521469     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Harris, E. S., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A. (2000) The leukocyte integrins. J. Biol. Chem. 275, 23409-23412.
2. Gahmberg, C. G. (1997) Leukocyte adhesion: CD11/CM18 integrins and intercellular adhesion molecules. Curr. Opin. Cell Biol. 9, 643-650.
3. van Kooyk, Y., Figdor, C. G. (1997) Signaling and adhesive properties of the integrin leucocyte function-associated antigen 1 (LFA-1), Biochem. Soc, Trans. 25, 515-520.
4. 2+-dependent protease, calpain. J. Cell Biol, 140, 669-707.
5. 2+-dependent epitope stimulates lymphocyte adhesion. J. Cell Biol. 112, 345-354.
6. Ortlepp, S., Stephens, P. E., Hogg, N., Figdor, C. C., Robinson, M. K. (1995) Antibodies that activate β2 integrins can generate different ligand binding states, Eur. J. Immunol. 25, 637-643.
7. Stephens, P., Romer, J. T., Shock, A., Ortlepp, S., Figdor, C., Robinson, M. K. (1995) KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats. Cell Adhes. Commun. 3, 375-384.
8. Sjaastad, M. D., Nelson, W. J. (1997) Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium. BioEssays 19, 47-55.
9. Kanner, S. B., Grosmaire, L. S., Ledbetter, J. A., Damle, N. K. (1993) β2-Integrin LFA-1 signaling through phospholipase C-γ 1 activation. Proc. Natl, Acad. Sci. USA 90, 7099-7103.
10. Arroyo, A. G., Campanero, M. R., Sánchez-Mateos, P., Zapata, J. M., Ursa, M. A., del Pozo, M. A., Sánchez-Madrid, F. (1994) Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. J. Cell Biol. 126, 1277-1286.
11. Lub, M., van Kooyk, Y., Figdor, C. G. (1995) Ins and outs of LFA-1. Immunol. Today 16, 479-489.
12. Rodríguez-Fernández, J. L., Gómez, M., Luque, A., Hogg, N., Sánchez-Madrid, F., Cabañas, C. (1999) The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. Mol. Biol. Cell 10, 1891-1907.
13. Avraham, S., London, R., Fu, Y., Ota, S., Hiregowdara, D., Li, J., Jiang, S., Pasztor, L. M., White, R. A., Groopman, J. E., Avraham, H. (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270, 27742-27751.
14. FAK. J. Biol. Chem. 270, 28440-28447.
15. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376, 737-745.
16. Sasaki, H., Nagura, K., Ishino, M., Tobioka, H., Kotani, K., Sasaki, T. (1995) Cloning and characterization of cell adhesion kinase β, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J. Biol. Chem. 270, 21206-21219.
17. Herzog, H., Nicholl, J., Hort, Y. J., Sutherland, G. R., Shine, J. (1996) Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization. Genomics 32, 484-486.
18. Avraham, H., Park, S. Y., Schinkmann, K., Avraham, S. (2000) RAFTK/Pyk2-mediated cellular signaling. Cell. Signal. 12, 123-133.
19. Yu, H., Li, X., Marchetto, G. S. Dy, R., Hunter, D., Calvo, B., Dawson, T. L., Wilm, M., Anderegg, R. J., Graves, L. M., Earp, H. S. (1996) Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J. Biol. Chem. 271, 29993-29998.
20. Liu, Z., Ganju, R. K., Wang, J., Schweitzer, K., Weksler, S., Avraham, S., Groopman, J. E. (1997) Characterization of signal transduction pathways in human bone marrow endothelial cells. Blood 90, 2253-2259.
21. Ganju, R. K., Dutt, P., Wu, L., Newman, H., Avraham, H., Avraham, S., Groopman, J. E. (1998) β-Chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood 91, 791-797.
22. Liu, Z. Y., Ganju, R. K., Wang, J. F., Ona, M. A., Hatch, W. C., Zheng, T., Avraham, S., Gill, P., Groopman, J. E. (1997) Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells. J. Clin. Investig. 99, 1798-1804.
23. Zohn, I., Yu, H., Li, X., Cox, A. D., Earp, H. S. (1995) Angiotensin II stimulates calcium-dependent activation of c-Jun N-terminal kinase. Mol. Cell. Biol. 15, 6160-6168.
24. Tokiwa, G., Dikic, I., Lev, S., Schlessinger, J. (1996) Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273, 792-794.
25. Li, X., Yu, H., Graves, L. M., Earp, H. S. (1997) Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells. J. Biol. Chem. 272, 14996-15002.
26. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A., Schlessinger, J. (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383, 547-550.
27. Mainiero, F., Gismondi, A., Soriani, A., Cippitelli, M., Palmieri, G., Jacobelli, J., Piccoli, M., Frati, L., Santoni, A. (1998) Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J. Exp. Med. 188, 1267-1275.
28. Pandey, P., Avraham, S., Kumar, S., Nakazawa, A., Place, A., Ghanem, L., Rana, A., Kumar, V., Majumder, P. K., Avraham, H., Davis, R. J., Kharbanda, S. (1999) Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. J. Biol. Chem. 274, 10140-10144.
29. Graves, L. M., He, Y., Lambert, J., Hunter, D., Li, X., Earp, H. S. (1997) An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells. J. Biol. Chem, 272, 1920-1928.
30. cas. J. Biol. Chem. 272, 228-232.
31. Ma, E. A., Lou, O., Berg, N. N., Ostergaard, H. L. (1997) Cytotoxic T lymphocytes express a β3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2. Eur. J. Immunol. 27, 329-335.
32. Li, J., Avraham, H., Rogers, R. A., Raja, S., Avraham, S. (1996) Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes. Blood 88, 417-428.
33. Hiregowdara, D., Avraham, H., Fy, Y., London, R., Avraham, S. (1997) Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. J. Biol. Chem. 272, 1080410810.
34. Raja, S., Avraham, S., Avraham, H. (1997) Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. J. Biol. Chem. 272, 10941-10947.
35. Luque, A., Gómez, M., Puzon, W., Takada, Y., Sánchez-Madrid, F., Cabañas, C. (1996) Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common β1 chain. J. Biol. Chem. 271, 11067-11075.
36. Cantrell, D. A., Smith, K. A. (1984) Interleukin 2 T cell system. A new model for cell growth. Science 224, 1312-1315.
37. Berendt, A. R., McDowall, A., Craig, A. G., Bates, P. A., Sternberg, M. J. E., Marsh, K., Newbold, C. I., Hogg, N. (1992) The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site. Cell 68, 71-81.
38. 2+ binding epitope on leukocyte integrin alpha subunits. EMBO J. 8, 3759-3765.
39. Dransfield, I., Cabañas, C., Barrett, J., Hogg, N. (1992) Interaction of leukocyte integrins with ligand is necessary but not sufficient for function. J. Cell Biol. 116, 1527-1535.
40. Campanero, M. R., del Pozo, M. A., Arroyo, A. G., Sánchez-Mateos, P., Hernández-Caselles, T., Craig, A., Pulido, R., Sánchez-Madrid, F. (1993) ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J. Cell Biol. 123, 1007-1016.
41. Sancho, D., Santis, A. G., Alonso-Lebrero, J. L., Viedma, F., Tejedor, R., Sánchez-Madrid, F. (2000) Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors. J. Immunol. 165, 3868-3875.
42. Stewart, M. P., Cabañas, C., Hogg, N. (1996) T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1. J. Immunol. 156, 1810-1817.
43. Dransfield, I., Cabañas, C., Craig, A., Hogg, N. (1992) Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol. 116, 219-226.
44. Cabañas, C., Hogg, N. (1993) Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1. Proc. Natl. Acad. Sci. USA 90, 5838-5842.
45. Weber, C., Katayama, J., Springer, T. A. (1996) Differential regulation of β1 and β2 integrin avidity by chemoattractants in eosinophils. Proc. Natl. Acad. Sci. USA 93, 10939-10944.
46. Sancho, D., Nieto, M., Llano, M., Rodríguez-Fernández, J. L., Tejedor, R., Avraham, S., Cabañas, C., López-Botet, M., Sánchez-Madrid, F. (2000) The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing. J. Cell Biol. 149, 1249-1262.
47. Rodríguez Fernández, J. L., Geiger, B., Salomon, D., Ben-Ze'ev, A. (1993) Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells. J. Cell Biol. 122, 1285-1294.
48. Rodríguez-Fernández, J. L., Rozengurt, E. (1998) Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells. J. Biol. Chem. 273, 19321-19328.
49. Rodríguez-Fernández, J. L. (1999) Why do so many stimuli induce tyrosine phosphorylation of FAK? BioEssays 21, 1069-1075.
50. Li, X., Hunter, D., Morris, J., Haskill, J. S., Earp, H. S. (1998) A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J. Biol. Chem. 273, 9361-9364.
51. Berridge, M. J., Lipp, P., Bootman, M. D. (2000) The versatility and universality of calcium signals. Nat. Rev. (Mol. Cell. Biol.) 1, 11-21.
52. Volkov, Y., Long, A., McGrath, S., Eidhin D. N., Kelleher, D. (2001) Crucial importance of PKC-β(I) in LFA-1-mediated locomotion of activated T cells. Nat. Immunol. 2, 508-514.
53. Volkov, Y., Long, A., Kelleher, D. (1998) Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes β(1) and δ. J. Immunol. 161, 6487-6495.
54. Herreros, L., Rodríguez-Fernández, J. L., Brown, M. C., Alonso-Lebrero, J. L., Cabañas, C., Sánchez-Madrid, F., Longo, N., Turner, C. E., Sánchez-Mateos, P. (2000) Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. J. Biol. Chem. 275, 26436-26440.