Evaluation of the BBMEC model for screening the CNS permeability of drugs

Journal of Pharmacological and Toxicological Methods

Volumn 45, Issue 1, 2001, Pages 71-77

  Otis, Kenneth W ^a   Avery, Michael L ^a   Broward Partin, Suzanne M ^a   Hansen, Dannette K ^a   Behlow Jr , Herbert W ^a   Scott, Dennis O ^b   Thompson, Thomas N ^a  

^a IQVIA   (United States)

^b PFIZER INC   (United States)

Author keywords

Blood brain barrier; CNS permeability; In vitro model; P glycoprotein; Transport study

Indexed keywords

ANTIPYRENE; CAFFEINE; CYCLOSPORIN A; GLYCOPROTEIN P; KETOPROFEN; LEUCINE; MACROGOL 400; MANNITOL; PHENYLALANINE; PHENYTOIN; PROPANOL; PYRENE DERIVATIVE; SUCROSE; TESTOSTERONE; THEOPHYLLINE; UNCLASSIFIED DRUG; VALERIC ACID; VINBLASTINE;

ANALYTIC METHOD; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; CENTRAL NERVOUS SYSTEM; COMBINATORIAL CHEMISTRY; DRUG PENETRATION; DRUG RESEARCH; DRUG SCREENING; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; NONHUMAN; REVIEW;

BOVINAE;

EID: 0034896546     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(01)00120-4     Document Type: Article

References (6)

1. Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism
2. Brain microvessel endothelial cell culture systems
3. A quantitative determination of permeability in BBMECs for vinblastine, a substrate for the p-glycoprotein efflux transporter
4. Development and validation of a method based on LC/MS/MS for the determination of MDL 100,907 and MDL 105,725 in microdialysis samples
5. An improved, higher throughput model for screening multiple analogs for CNS penetration