Integral membrane protein biosynthesis: Why topology is hard to predict

Journal of Cell Science

Volumn 115, Issue 10, 2002, Pages 2003-2009

  Ott, Carolyn M ^a   Lingappa, Vishwanath R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biogenesis; Endoplasmic reticulum; Signal transduction; Topogenesis; Translocon

Indexed keywords

MEMBRANE PROTEIN;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; CELL ANCHORAGE; CONTROLLED STUDY; HUMAN; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TERTIARY STRUCTURE; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; METABOLISM; PROTEIN PROCESSING; PROTEIN TRANSPORT; REVIEW;

ALGORITHMS; ANIMAL; CELL MEMBRANE; HYDROPHOBICITY; MEMBRANE PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 0037092503     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. The role of the N region in signal sequence and signal-anchor function
2. Architecture of the protein-conducting channel associated with the translating 80S ribosome
3. Membrane integration of Na,K-ATPase alpha-subunits and beta-subunit assembly
4. Membrane protein folding
5. Biogenesis of polytopic membrane proteins - Membrane segments assemble within translocation channels prior to membrane integration
6. Mechanism of polypeptide translocation into the endoplasmic reticulum
7. Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: The dense alignment surface method
8. TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales
9. The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process
10. Membrane insertion and assembly of Ductin - A polytopic channel with dual orientations
11. Purification of microsomal signal peptidase as a complex
12. Negatively charged residues in the IgM stop-transfer effector sequence regulate transmembrane polypeptide integration
13. Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access
14. SR beta coordinates signal sequence release from SRP with ribosome binding to the translocon
15. Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon
16. A protein of the endoplasmic reticulum involved early in polypeptide translocation
17. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
18. A new role for BiP: Closing the aqueous translocon pore during protein integration into the ER membrane
19. The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane
20. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
21. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation
22. Regulation of protein biogenesis at the endoplasmic reticulum membrane
23. A transmembrane form of the prion protein in neurodegenerative disease
24. Regulation of protein topology by trans-acting factors at the endoplasmic reticulum
25. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum
26. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain
27. Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein
28. Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences
29. Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins
30. Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain
31. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane
32. A simple method for displaying the hydropathic character of a protein
33. A novel integration signal that is composed of two transmembrane segments is required to integrate the Neurospora plasma membrane H+-Atpase into microsomes
34. Unusual topogenic sequence directs prion protein biogenesis
35. Protein translocation: Tunnel vision
36. A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane
37. Molecular mechanism of membrane protein integration into the endoplasmic reticulum
38. Assessment of topogenic functions of anticipated transmembrane segments of human band 3
39. Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins
40. Membrane integration of the second transmembrane segment of band 3 requires a closely apposed preceding signal-anchor sequence
41. Intracellular aspects of the process of protein synthesis
42. Membrane protein folding and oligomerization - The 2-stage model
43. Helical membrane protein folding, stability, and evolution
44. Mapping the ends of transmembrane segments in a polytopic membrane protein. Scanning N-glycosylation mutagenesis of extracytosolic loops in the anion exchanger, band 3
45. Approaches to determining membrane protein structures to high resolution: Do selections of subpopulations occur?
46. Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations
47. Substrate-specific regulation of the ribosome-translocon junction by N-terminal signal sequences
48. Misfolding of membrane proteins in health and disease: The lady or the tiger?
49. Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences
50. A hidden Markov model for predicting transmembrane helices in protein sequences
51. The structure and function of band 3 (AE1): Recent developments
52. A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation
53. Principles governing amino acid composition of integral membrane proteins: Application to topology prediction
54. The HMMTOP transmembrane topology prediction server
55. Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane
56. Membrane protein structure prediction - Hydrophobicity analysis and the positive-inside rule
57. Recent advances in the understanding of membrane protein assembly and structure
58. Cotranslational integration of myelin proteolipid protein (PLP) into the membrane of endoplasmic reticulum: Analysis of topology by glycosylation scanning and protease domain protection assay
59. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
60. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein