Genetically engineered dopamine β-hydroxylase gene promoters with better PHOX2-binding sites drive significantly enhanced transgene expression in a noradrenergic cell-specific manner

Molecular Therapy

Volumn 11, Issue 1, 2005, Pages 132-141

  Hwang, Dong Youn ^a   Hwang, Michelle M ^a   Kim, Han Soo ^a   Kim, Kwang Soo ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b MRC 215 ^*  (United States)

Author keywords

Cell type specific; Gene delivery; Gene expression; Human dopamine hydroxylase; Noradrenergic neuron; PHOX2; Promoter

Indexed keywords

DOPAMINE BETA MONOOXYGENASE; NORADRENALIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PHOX2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL SPECIFICITY; CELL STRAIN HEPG2; CELL TYPE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ENGINEERING; HELA CELL; HUMAN; HUMAN CELL; NORADRENERGIC NERVE; NUCLEOTIDE SEQUENCE; PROCESS OPTIMIZATION; PROMOTER REGION; TRANSGENE;

ANIMALS; BASE SEQUENCE; BINDING SITES; BRAIN; CELL LINE, TUMOR; DOPAMINE BETA-HYDROXYLASE; GENES, REPORTER; GENETIC ENGINEERING; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS; TRANSGENES;

ANIMALIA;

EID: 10944250706     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.017     Document Type: Article

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