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Volumn 71, Issue 4, 1998, Pages 1358-1368

Identification and characterization of potential cis-regulatory elements governing transcriptional activation of the rat tyrosine hydroxylase gene

Author keywords

Cell type specific transcription; Cis Regulatory elements; Cyclic AMP response element; Dopamine hydroxylase; Transcription factor Sp1; Transcriptional regulation; Tyrosine hydroxylase

Indexed keywords

CYCLIC AMP; TRANSCRIPTION FACTOR SP1; TYROSINE 3 MONOOXYGENASE;

EID: 0031666552     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71041358.x     Document Type: Article
Times cited : (48)

References (48)
  • 1
    • 0021229536 scopus 로고
    • Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: Specificity and level of regulation
    • Acheson A. L., Naujoks K., and Thoenen H. (1984) Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: specificity and level of regulation. J. Neurosci. 4, 1771-1780.
    • (1984) J. Neurosci. , vol.4 , pp. 1771-1780
    • Acheson, A.L.1    Naujoks, K.2    Thoenen, H.3
  • 2
    • 0026541828 scopus 로고
    • 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice
    • Banerjee S. A., Hoppe P., Brilliant M., and Chikaraishi D. M. (1992) 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. J. Neurosci. 12, 4460-4467.
    • (1992) J. Neurosci. , vol.12 , pp. 4460-4467
    • Banerjee, S.A.1    Hoppe, P.2    Brilliant, M.3    Chikaraishi, D.M.4
  • 3
    • 0028871997 scopus 로고
    • The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements
    • Best J. A., Chen Y., Piech K. M., and Tank A. W. (1995) The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements. J. Neurochem. 65, 1934-1943.
    • (1995) J. Neurochem. , vol.65 , pp. 1934-1943
    • Best, J.A.1    Chen, Y.2    Piech, K.M.3    Tank, A.W.4
  • 4
    • 0023007801 scopus 로고
    • Purification and biochemical characterization of the promoter-specific transcription factor. Sp1
    • Briggs M. R., Kadonaga J. T., Bell S. P., and Tjian R. (1986) Purification and biochemical characterization of the promoter-specific transcription factor. Sp1. Science 234, 47-52.
    • (1986) Science , vol.234 , pp. 47-52
    • Briggs, M.R.1    Kadonaga, J.T.2    Bell, S.P.3    Tjian, R.4
  • 5
    • 0024421363 scopus 로고
    • 5′ flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase
    • Cambi F., Fung B., and Chikaraishi D. (1989) 5′ flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase. J. Neurochem. 53, 1656-1659.
    • (1989) J. Neurochem. , vol.53 , pp. 1656-1659
    • Cambi, F.1    Fung, B.2    Chikaraishi, D.3
  • 6
    • 0024492340 scopus 로고
    • Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineages
    • Ciccarone V., Spengler B. A., Meyers M. B., Biedler J. L., and Ross R. A. (1989) Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res. 49, 219-225.
    • (1989) Cancer Res. , vol.49 , pp. 219-225
    • Ciccarone, V.1    Spengler, B.A.2    Meyers, M.B.3    Biedler, J.L.4    Ross, R.A.5
  • 7
    • 0028275393 scopus 로고
    • The oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter
    • Dawson S. J., Yoon S. O., Chikaraishi D. M., and Latchman D. S. (1994) The oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. Nucleic Acids Res. 22, 1023-1028.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 1023-1028
    • Dawson, S.J.1    Yoon, S.O.2    Chikaraishi, D.M.3    Latchman, D.S.4
  • 8
    • 0025301561 scopus 로고
    • Interaction of cAMP and cell-cell contact in the control of tyrosine hydroxylase RNA
    • Fader D. and Lewis E. J. (1990) Interaction of cAMP and cell-cell contact in the control of tyrosine hydroxylase RNA. Mol. Brain Res. 8, 25-29.
    • (1990) Mol. Brain Res. , vol.8 , pp. 25-29
    • Fader, D.1    Lewis, E.J.2
  • 9
    • 0026508808 scopus 로고
    • Compilation for vertebrate-encoded transcription factors
    • Faisst S. and Meyer S. (1992) Compilation for vertebrate-encoded transcription factors. Nucleic Acids Res. 20, 3-26.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3-26
    • Faisst, S.1    Meyer, S.2
  • 10
    • 0026599021 scopus 로고
    • Chromatin as an essential part of the transcriptional mechanism
    • Felsenfeld G. (1992) Chromatin as an essential part of the transcriptional mechanism. Nature 355, 219-224.
    • (1992) Nature , vol.355 , pp. 219-224
    • Felsenfeld, G.1
  • 11
    • 0026719493 scopus 로고
    • Sequences that direct rat tyrosine hydroxylase gene expression
    • Fung B. P., Yoon S. O., and Chikaraishi D. M. (1992) Sequences that direct rat tyrosine hydroxylase gene expression. J. Neurochem. 58, 2044-2052.
    • (1992) J. Neurochem. , vol.58 , pp. 2044-2052
    • Fung, B.P.1    Yoon, S.O.2    Chikaraishi, D.M.3
  • 12
    • 0025689172 scopus 로고
    • Species and regional differences in the expression of cell-type specific elements at the human and rat tyrosine hydroxylase gene loci
    • Gandelman K.-Y., Coker G. T. III, Moffat M., and O'Malley K. L. (1990) Species and regional differences in the expression of cell-type specific elements at the human and rat tyrosine hydroxylase gene loci. J. Neurochem. 55, 2149-2152.
    • (1990) J. Neurochem. , vol.55 , pp. 2149-2152
    • Gandelman, K.-Y.1    Coker III, G.T.2    Moffat, M.3    O'Malley, K.L.4
  • 13
    • 0025230762 scopus 로고
    • Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nuclear protein complex that contains c-fos
    • Gizang-Ginsberg E. and Ziff E. B. (1990) Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nuclear protein complex that contains c-fos. Genes Dev. 4, 477-491.
    • (1990) Genes Dev. , vol.4 , pp. 477-491
    • Gizang-Ginsberg, E.1    Ziff, E.B.2
  • 14
    • 0028791345 scopus 로고
    • Functional analyses of the transcription factor Sp4 reveal properties distinct from SpI and Sp3
    • Hagen G., Dennig J., Preiss A., Beato M., and Suske G. (1995) Functional analyses of the transcription factor Sp4 reveal properties distinct from SpI and Sp3. J. Biol. Chem. 270, 24989-24994.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24989-24994
    • Hagen, G.1    Dennig, J.2    Preiss, A.3    Beato, M.4    Suske, G.5
  • 15
    • 0023650570 scopus 로고
    • Identification and cell type specificity of tyrosine hydroxylase gene promoter
    • Harrington C. A., Lewis E. J., Krzemien D., and Chikaraishi D. M. (1987) Identification and cell type specificity of tyrosine hydroxylase gene promoter. Nucleic Acids Res. 15, 2363-2384.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 2363-2384
    • Harrington, C.A.1    Lewis, E.J.2    Krzemien, D.3    Chikaraishi, D.M.4
  • 16
    • 0026717503 scopus 로고
    • AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic induction of the tyrosine hydroxylase gene: Insights into long-term regulatory mechanisms
    • Icard-Liepkalns C., Faucon Biguet N., Vyas S., Robert J. J., Sassone-Corsi P., and Mallet J. (1992) AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic induction of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms. J. Neurosci. Res. 32, 290-298.
    • (1992) J. Neurosci. Res. , vol.32 , pp. 290-298
    • Icard-Liepkalns, C.1    Faucon Biguet, N.2    Vyas, S.3    Robert, J.J.4    Sassone-Corsi, P.5    Mallet, J.6
  • 17
    • 0027257578 scopus 로고
    • Neuron-specific expression of the human dopamine β-hydroxylase gene requires both cyclic AMP response element and a silencer region
    • Ishiguro H., Kim K. T., Joh T. H., and Kim K. S. (1993) Neuron-specific expression of the human dopamine β-hydroxylase gene requires both cyclic AMP response element and a silencer region. J. Biol. Chem. 268, 17987-17994.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17987-17994
    • Ishiguro, H.1    Kim, K.T.2    Joh, T.H.3    Kim, K.S.4
  • 18
    • 0029562789 scopus 로고
    • Identification of a negative regulatory element in the 5′-flanking region of the human dopamine β-hydroxylase gene
    • Ishiguro H., Kim K. S., and Joh T. H. (1995) Identification of a negative regulatory element in the 5′-flanking region of the human dopamine β-hydroxylase gene. Mol. Brain Res. 34, 251-261.
    • (1995) Mol. Brain Res. , vol.34 , pp. 251-261
    • Ishiguro, H.1    Kim, K.S.2    Joh, T.H.3
  • 21
    • 0027291181 scopus 로고
    • Both the basal and inducible transcription of the tyrosine hydroxylase (TH) gene are dependent on a cAMP-response element
    • Kim K.-S., Lee M. D., Carroll J., and Joh T. H. (1993) Both the basal and inducible transcription of the tyrosine hydroxylase (TH) gene are dependent on a cAMP-response element. J. Biol. Chem. 268, 15689-15695.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15689-15695
    • Kim, K.-S.1    Lee, M.D.2    Carroll, J.3    Joh, T.H.4
  • 22
    • 0031840539 scopus 로고    scopus 로고
    • The cell-specific silencer region of the human dopamine β-hydroxylase gene contains several negative regulatory elements
    • Kim H.-S., Yang C., and Kim K.-S. (1998) The cell-specific silencer region of the human dopamine β-hydroxylase gene contains several negative regulatory elements. J. Neurochem. 71, 41-50.
    • (1998) J. Neurochem. , vol.71 , pp. 41-50
    • Kim, H.-S.1    Yang, C.2    Kim, K.-S.3
  • 23
    • 0026727120 scopus 로고
    • Chromatin structure and transcription
    • Konberg R. D. and Lorch Y. (1992) Chromatin structure and transcription. Annu. Rev. Cell Biol. 3, 563-587.
    • (1992) Annu. Rev. Cell Biol. , vol.3 , pp. 563-587
    • Konberg, R.D.1    Lorch, Y.2
  • 24
    • 0030017489 scopus 로고    scopus 로고
    • Intricate regulation of tyrosine hydroxylase activity and gene expression
    • Kumer S. C. and Vrana K. E. (1996) Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem. 67, 443-462.
    • (1996) J. Neurochem. , vol.67 , pp. 443-462
    • Kumer, S.C.1    Vrana, K.E.2
  • 25
    • 0029095907 scopus 로고
    • The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice
    • Lazaroff M., Patankar S., Yoon S. O., and Chikaraishi D. M. (1995) The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice. J. Biol. Chem. 270, 21579-21589.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21579-21589
    • Lazaroff, M.1    Patankar, S.2    Yoon, S.O.3    Chikaraishi, D.M.4
  • 26
    • 0023649835 scopus 로고
    • CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
    • Luckow B. and Schutz G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15, 5490.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 5490
    • Luckow, B.1    Schutz, G.2
  • 27
    • 0028556985 scopus 로고
    • Different members of the SpI multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1
    • Majello B., De Luca P., Hagen G., Suske G., and Lania L. (1994) Different members of the SpI multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res. 22, 4914-4921.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4914-4921
    • Majello, B.1    De Luca, P.2    Hagen, G.3    Suske, G.4    Lania, L.5
  • 28
    • 0028172887 scopus 로고
    • 5′ upstream DNA sequences of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the CNS of transgenic mice
    • Min N., Joh T. H., Kim K.-S., Peng C., and Son J. H. (1994) 5′ upstream DNA sequences of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the CNS of transgenic mice. Mol. Brain Res. 27, 281-289.
    • (1994) Mol. Brain Res. , vol.27 , pp. 281-289
    • Min, N.1    Joh, T.H.2    Kim, K.-S.3    Peng, C.4    Son, J.H.5
  • 29
    • 0030052630 scopus 로고    scopus 로고
    • 3.6 kb of the 5′ flanking DNA activates the mouse tyrosine hydroxylase gene promoter without catecholaminergic-specinc expression
    • Morgan W. W., Walter C. A., Windle J. J., and Sharp Z. D. (1996) 3.6 kb of the 5′ flanking DNA activates the mouse tyrosine hydroxylase gene promoter without catecholaminergic-specinc expression. J. Neurochem. 66, 20-25.
    • (1996) J. Neurochem. , vol.66 , pp. 20-25
    • Morgan, W.W.1    Walter, C.A.2    Windle, J.J.3    Sharp, Z.D.4
  • 30
    • 9044252959 scopus 로고
    • Tyrosine hydroxylase; the initial step in norepinephrine biosynthesis
    • Nagatsu T., Levitt M., and Udenfriend S. (1964) Tyrosine hydroxylase; the initial step in norepinephrine biosynthesis. J. Biol. Chem. 239, 2910-2917.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2910-2917
    • Nagatsu, T.1    Levitt, M.2    Udenfriend, S.3
  • 32
    • 0030973033 scopus 로고    scopus 로고
    • Tissue-specific methylation occurs in the essential promoter element of the tyrosine hydroxylase gene
    • Okuse K., Matsuoka I., and Kurihara K. (1997) Tissue-specific methylation occurs in the essential promoter element of the tyrosine hydroxylase gene. Mol. Brain Res. 46, 197-207.
    • (1997) Mol. Brain Res. , vol.46 , pp. 197-207
    • Okuse, K.1    Matsuoka, I.2    Kurihara, K.3
  • 33
    • 0031002927 scopus 로고    scopus 로고
    • An adenoviral vector-based system to study neuronal gene expression: Analysis of the rat tyrosine hydroxylase promoter in cultured neurons
    • Robert J. J., Geoffroy M. C., Finiels F., and Mallet J. (1997) An adenoviral vector-based system to study neuronal gene expression: analysis of the rat tyrosine hydroxylase promoter in cultured neurons. J. Neurochem. 68, 2152-2160.
    • (1997) J. Neurochem. , vol.68 , pp. 2152-2160
    • Robert, J.J.1    Geoffroy, M.C.2    Finiels, F.3    Mallet, J.4
  • 35
    • 0024266415 scopus 로고
    • The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0
    • Sekulovich R. E., Leary K., and Sandri-Goldin R. M. (1988) The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0. J. Virol. 62, 4510-4522.
    • (1988) J. Virol. , vol.62 , pp. 4510-4522
    • Sekulovich, R.E.1    Leary, K.2    Sandri-Goldin, R.M.3
  • 36
    • 0029905502 scopus 로고    scopus 로고
    • Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine β-hydroxylase gene
    • Seo H., Yang C., Kim H.-S., and Kim K. S. (1996) Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine β-hydroxylase gene. J. Neurosci. 16, 4102-4111.
    • (1996) J. Neurosci. , vol.16 , pp. 4102-4111
    • Seo, H.1    Yang, C.2    Kim, H.-S.3    Kim, K.S.4
  • 37
    • 0026655584 scopus 로고
    • A bifunctional genetic regulatory element of the rat dopamine β-hydroxylase gene influences cell type-specific and second messenger-mediated transcription
    • Shaskus J., Greco D., Asnani L. P., and Lewis E. J. (1992) A bifunctional genetic regulatory element of the rat dopamine β-hydroxylase gene influences cell type-specific and second messenger-mediated transcription. J. Biol. Chem. 267, 18821-18830.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18821-18830
    • Shaskus, J.1    Greco, D.2    Asnani, L.P.3    Lewis, E.J.4
  • 38
    • 0027394509 scopus 로고
    • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice
    • Suri A., Fung B. P., Tischler A. S., and Chikaraishi D. M. (1993) Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. J. Neurosci. 13, 1280-1291.
    • (1993) J. Neurosci. , vol.13 , pp. 1280-1291
    • Suri, A.1    Fung, B.P.2    Tischler, A.S.3    Chikaraishi, D.M.4
  • 39
    • 0030814764 scopus 로고    scopus 로고
    • Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription
    • Tinti C., Yang C.. Seo H.. Conti B., Kim C., Joh T. H., and Kim K.-S. (1997) Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription. J. Biol. Chem. 272, 19158-19164.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19158-19164
    • Tinti, C.1    Yang, C.2    Seo, H.3    Conti, B.4    Kim, C.5    Joh, T.H.6    Kim, K.-S.7
  • 40
    • 0028236523 scopus 로고
    • Transcription: In tune with the histones
    • Wolffe A. P. (1994) Transcription: in tune with the histones. Cell 77, 13-16.
    • (1994) Cell , vol.77 , pp. 13-16
    • Wolffe, A.P.1
  • 41
    • 0029997378 scopus 로고    scopus 로고
    • Targeting chromatin disruption: Transcription regulators that acetylate histones
    • Wolffe A. P. and Pruss D. (1996) Targeting chromatin disruption: transcription regulators that acetylate histones. Cell 84, 817-819.
    • (1996) Cell , vol.84 , pp. 817-819
    • Wolffe, A.P.1    Pruss, D.2
  • 42
    • 0028295219 scopus 로고
    • Sequences distal to the AP1/E box motif are involved in the cell type-specific expression of the rat tyrosine hydroxylase gene
    • Wong S. C., Moffat M. A., and O'Malley K. L. (1994) Sequences distal to the AP1/E box motif are involved in the cell type-specific expression of the rat tyrosine hydroxylase gene. J. Neurochem. 62, 1691-1697.
    • (1994) J. Neurochem. , vol.62 , pp. 1691-1697
    • Wong, S.C.1    Moffat, M.A.2    O'Malley, K.L.3
  • 43
    • 0029051424 scopus 로고
    • The 3′ flanking region of the human tyrosine hydroxylase gene directs reporter gene expression in peripheral neuroendocrine tissues
    • Wong S. C., Moffat M. A., Coker G. T., Merlie J. P., and O'Malley K. L. (1995) The 3′ flanking region of the human tyrosine hydroxylase gene directs reporter gene expression in peripheral neuroendocrine tissues. J. Neurochem. 65, 23-31.
    • (1995) J. Neurochem. , vol.65 , pp. 23-31
    • Wong, S.C.1    Moffat, M.A.2    Coker, G.T.3    Merlie, J.P.4    O'Malley, K.L.5
  • 44
    • 0026703977 scopus 로고
    • Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping e box-containing dyad
    • Yoon S. O. and Chikaraishi D. M. (1992) Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. Neuron 9, 55-67.
    • (1992) Neuron , vol.9 , pp. 55-67
    • Yoon, S.O.1    Chikaraishi, D.M.2
  • 45
    • 0028337445 scopus 로고
    • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer
    • Yoon S. O. and Chikaraishi D. M. (1994) Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. J. Biol. Chem. 269, 18453-18462.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18453-18462
    • Yoon, S.O.1    Chikaraishi, D.M.2
  • 46
    • 0029588435 scopus 로고
    • Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
    • Zhou Q.-Y. and Palmiter R. D. (1995) Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83, 1197-1209.
    • (1995) Cell , vol.83 , pp. 1197-1209
    • Zhou, Q.-Y.1    Palmiter, R.D.2
  • 47
    • 0028912476 scopus 로고
    • Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
    • Zhou Q.-Y., Qualfe C. J., and Palmiter R. D. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374, 640-643.
    • (1995) Nature , vol.374 , pp. 640-643
    • Zhou, Q.-Y.1    Qualfe, C.J.2    Palmiter, R.D.3
  • 48
    • 0024582213 scopus 로고
    • Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation
    • Zigmond R. E., Schwarzschild M. A., and Rittenhouse A. R. (1989) Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12, 415-461.
    • (1989) Annu. Rev. Neurosci. , vol.12 , pp. 415-461
    • Zigmond, R.E.1    Schwarzschild, M.A.2    Rittenhouse, A.R.3


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