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Volumn 22, Issue 7, 2002, Pages 2579-2589

A Proximal Promoter Domain Containing a Homeodomain-Binding Core Motif Interacts with Multiple Transcription Factors, Including HoxA5 and Phox2 Proteins, and Critically Regulates Cell Type-Specific Transcription of the Human Norepinephrine Transporter Gene

Author keywords

Cell type specific transcription; Cis acting element; Homeodomain; HoxA5; Noradrenergic neuron; Norepinephrine transporter; Phox2a; Promoter

Indexed keywords

DEOXYRIBONUCLEASE I; DOPAMINE BETA MONOOXYGENASE; HOMEODOMAIN PROTEIN; NORADRENALIN TRANSPORTER; PROTEIN FACTOR; PROTEIN HOXA5; PROTEIN PHOX2A; UNCLASSIFIED DRUG; COTRANSPORTER; HOXA5 PROTEIN, HUMAN; NERVE PROTEIN; PHOSPHOPROTEIN; PHOX2A PROTEIN, HUMAN; SLC6A2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 0036551206     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-07-02579.2002     Document Type: Article
Times cited : (22)

References (59)
  • 1
    • 0014453248 scopus 로고
    • The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves
    • Axelrod J, Kopin IJ (1969) The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. Prog Brain Res 31:21-32.
    • (1969) Prog Brain Res , vol.31 , pp. 21-32
    • Axelrod, J.1    Kopin, I.J.2
  • 2
    • 0026541828 scopus 로고
    • 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice
    • Banerjee SA, Hoppe P, Brilliant M, Chikaraishi DM (1992) 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. J Neurosci 12:4460-4467.
    • (1992) J Neurosci , vol.12 , pp. 4460-4467
    • Banerjee, S.A.1    Hoppe, P.2    Brilliant, M.3    Chikaraishi, D.M.4
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 0031574095 scopus 로고    scopus 로고
    • The rat norepinephrine transporter: Molecular cloning from PC12 cells and functional expression
    • Bruss M, Porzgen P, Bryan-Lluka LJ, Bonisch H (1997) The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression. Brain Res Mol Brain Res 52:257-262.
    • (1997) Brain Res Mol Brain Res , vol.52 , pp. 257-262
    • Bruss, M.1    Porzgen, P.2    Bryan-Lluka, L.J.3    Bonisch, H.4
  • 5
    • 0028940962 scopus 로고
    • Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase
    • Cockell M, Stolarczyk D, Frutiger S, Hughes GJ, Hagenbuchle O, Wellauer PK (1995) Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase. Mol Cell Biol 15:1933-1941.
    • (1995) Mol Cell Biol , vol.15 , pp. 1933-1941
    • Cockell, M.1    Stolarczyk, D.2    Frutiger, S.3    Hughes, G.J.4    Hagenbuchle, O.5    Wellauer, P.K.6
  • 6
    • 0032512115 scopus 로고    scopus 로고
    • Noradrenaline transporter expression in the pons and medulla oblongata of the rat: Localisation to noradrenergic and some C1 adrenergic neurones
    • Comer AM, Qi J, Christie DL, Gibbons HM, Lipski J (1998) Noradrenaline transporter expression in the pons and medulla oblongata of the rat: localisation to noradrenergic and some C1 adrenergic neurones. Brain Res Mol Brain Res 62:65-76.
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 65-76
    • Comer, A.M.1    Qi, J.2    Christie, D.L.3    Gibbons, H.M.4    Lipski, J.5
  • 7
    • 0024695889 scopus 로고
    • Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements
    • Crenshaw III EB, Kalla K, Simmons DM, Swanson LW, Rosenfeld MG (1989) Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements. Genes Dev 3:959-972.
    • (1989) Genes Dev , vol.3 , pp. 959-972
    • Crenshaw III, E.B.1    Kalla, K.2    Simmons, D.M.3    Swanson, L.W.4    Rosenfeld, M.G.5
  • 8
    • 0029115976 scopus 로고
    • Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus
    • Cubells JF, Kim KS, Baker H, Volpe BT, Chung Y, Houpt TA, Wessel TC, Joh TH (1995) Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus. J Neurochem 65:502-509.
    • (1995) J Neurochem , vol.65 , pp. 502-509
    • Cubells, J.F.1    Kim, K.S.2    Baker, H.3    Volpe, B.T.4    Chung, Y.5    Houpt, T.A.6    Wessel, T.C.7    Joh, T.H.8
  • 9
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 10
    • 0033232474 scopus 로고    scopus 로고
    • The role of norepinephrine in the pathophvsiology of cognitive disorders: Potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease
    • Friedman JI, Adler DN, Davis KL (1999) The role of norepinephrine in the pathophvsiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease. Biol Psychiatry 46:1243-1252.
    • (1999) Biol Psychiatry , vol.46 , pp. 1243-1252
    • Friedman, J.I.1    Adler, D.N.2    Davis, K.L.3
  • 11
    • 0021112458 scopus 로고
    • An improved strategy for rapid direct sequencing of both strands of long DNA molecules cloned in a plasmid
    • Guo LH, Yang RC, Wu R (1983) An improved strategy for rapid direct sequencing of both strands of long DNA molecules cloned in a plasmid. Nucleic Acids Res 11:5521-5540.
    • (1983) Nucleic Acids Res , vol.11 , pp. 5521-5540
    • Guo, L.H.1    Yang, R.C.2    Wu, R.3
  • 13
    • 0021253525 scopus 로고
    • Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
    • Henikoff S (1984) Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene 28:351-359.
    • (1984) Gene , vol.28 , pp. 351-359
    • Henikoff, S.1
  • 14
    • 0028345494 scopus 로고
    • Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements
    • Hoyle GW, Mercer EH, Palmiter RD, Brinster RL (1994) Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J Neurosci 14:2455-2463.
    • (1994) J Neurosci , vol.14 , pp. 2455-2463
    • Hoyle, G.W.1    Mercer, E.H.2    Palmiter, R.D.3    Brinster, R.L.4
  • 15
    • 0034808550 scopus 로고    scopus 로고
    • A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons
    • Hwang D-Y, Carlezon WA, Isacson O, Kim KS (2001) A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther 12:1731-1740.
    • (2001) Hum Gene Ther , vol.12 , pp. 1731-1740
    • Hwang, D.-Y.1    Carlezon, W.A.2    Isacson, O.3    Kim, K.S.4
  • 16
    • 0027257578 scopus 로고
    • Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region
    • Ishiguro H, Kim KT, Joh TH, Kim KS (1993) Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region. J Biol Chem 268:17987-17994.
    • (1993) J Biol Chem , vol.268 , pp. 17987-17994
    • Ishiguro, H.1    Kim, K.T.2    Joh, T.H.3    Kim, K.S.4
  • 17
    • 0024791938 scopus 로고
    • Molecular cloning and characterization of a human DNA binding factor that represses transcription
    • Kageyama R, Pastan I (1989) Molecular cloning and characterization of a human DNA binding factor that represses transcription. Cell 59:815-825.
    • (1989) Cell , vol.59 , pp. 815-825
    • Kageyama, R.1    Pastan, I.2
  • 18
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
    • Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T (1990) Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344:879-882.
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 19
    • 0033525881 scopus 로고    scopus 로고
    • A previously undescribed intron and extensive 5′ upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene
    • Kim CH, Kim HS, Cubells JF, Kim KS (1999) A previously undescribed intron and extensive 5′ upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. J Biol Chem 274:6507-6518.
    • (1999) J Biol Chem , vol.274 , pp. 6507-6518
    • Kim, C.H.1    Kim, H.S.2    Cubells, J.F.3    Kim, K.S.4
  • 20
    • 0035816625 scopus 로고    scopus 로고
    • An e-box motif residing in the exon/intron 1 junction regulates both transcriptional activation and splicing of the human norepinephrine transporter gene
    • Kim CH, Ardayfio P, Kim KS (2001) An e-box motif residing in the exon/intron 1 junction regulates both transcriptional activation and splicing of the human norepinephrine transporter gene. J Biol Chem 276:24797-24805.
    • (2001) J Biol Chem , vol.276 , pp. 24797-24805
    • Kim, C.H.1    Ardayfio, P.2    Kim, K.S.3
  • 21
    • 0032531711 scopus 로고    scopus 로고
    • Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites
    • Kim HS, Seo H, Yang C, Brunet JF, Kim KS (1998) Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites. J Neurosci 18:8247-8260.
    • (1998) J Neurosci , vol.18 , pp. 8247-8260
    • Kim, H.S.1    Seo, H.2    Yang, C.3    Brunet, J.F.4    Kim, K.S.5
  • 22
  • 23
    • 0028032441 scopus 로고
    • The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene
    • Kim KS, Ishiguro H, Tinti C, Wagner J, Joh TH (1994) The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene. J Neurosci 14:7200-7207.
    • (1994) J Neurosci , vol.14 , pp. 7200-7207
    • Kim, K.S.1    Ishiguro, H.2    Tinti, C.3    Wagner, J.4    Joh, T.H.5
  • 24
    • 0029035303 scopus 로고
    • Cooperation between elements of an organ-specific transcriptional enhancer in animals
    • Kruse F, Rose SD, Swift GH, Hammer RE, MacDonald RJ (1995) Cooperation between elements of an organ-specific transcriptional enhancer in animals. Mol Cell Biol 15:4385-4394.
    • (1995) Mol Cell Biol , vol.15 , pp. 4385-4394
    • Kruse, F.1    Rose, S.D.2    Swift, G.H.3    Hammer, R.E.4    MacDonald, R.J.5
  • 25
    • 0020611436 scopus 로고
    • Recognition sites for norepinephrine uptake: Regulation by neurotransmitter
    • Lee CM, Javitch JA, Snyder SH (1983) Recognition sites for norepinephrine uptake: regulation by neurotransmitter. Science 220:626-629.
    • (1983) Science , vol.220 , pp. 626-629
    • Lee, C.M.1    Javitch, J.A.2    Snyder, S.H.3
  • 26
    • 0028207391 scopus 로고
    • Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter
    • Lingen B, Bruss M, Bonisch H (1994) Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter. FEBS Lett 342:235-238.
    • (1994) FEBS Lett , vol.342 , pp. 235-238
    • Lingen, B.1    Bruss, M.2    Bonisch, H.3
  • 27
    • 0027933179 scopus 로고
    • Cell-type-specific expression of catecholamine transporters in the rat brain
    • Lorang D, Amara SG, Simerly RB (1994) Cell-type-specific expression of catecholamine transporters in the rat brain. J Neurosci 14:4903-4914.
    • (1994) J Neurosci , vol.14 , pp. 4903-4914
    • Lorang, D.1    Amara, S.G.2    Simerly, R.B.3
  • 28
    • 0028172887 scopus 로고
    • 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice
    • Min N, Joh TH, Kim KS, Peng C, Son JH (1994) 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Brain Res Mol Brain Res 27:281-289.
    • (1994) Brain Res Mol Brain Res , vol.27 , pp. 281-289
    • Min, N.1    Joh, T.H.2    Kim, K.S.3    Peng, C.4    Son, J.H.5
  • 29
    • 0030936255 scopus 로고    scopus 로고
    • Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a
    • Morin X, Cremer H, Hirsch MR, Kapur RP, Goridis C, Brunet JF (1997) Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron 18:411-423.
    • (1997) Neuron , vol.18 , pp. 411-423
    • Morin, X.1    Cremer, H.2    Hirsch, M.R.3    Kapur, R.P.4    Goridis, C.5    Brunet, J.F.6
  • 30
    • 0033528752 scopus 로고    scopus 로고
    • Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion
    • Nishimura M, Sato K, Shimada S, Tohyama M (1999) Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain Res Mol Brain Res 67:82-86.
    • (1999) Brain Res Mol Brain Res , vol.67 , pp. 82-86
    • Nishimura, M.1    Sato, K.2    Shimada, S.3    Tohyama, M.4
  • 32
    • 0028168589 scopus 로고
    • Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide
    • Ordway GA, Widdowson PS, Smith KS, Halaris A (1994) Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. J Neurochem 63:617-624.
    • (1994) J Neurochem , vol.63 , pp. 617-624
    • Ordway, G.A.1    Widdowson, P.S.2    Smith, K.S.3    Halaris, A.4
  • 33
    • 0031456987 scopus 로고    scopus 로고
    • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites
    • Owens MJ, Morgan WN, Plott SJ, Nemeroff CB (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1305-1322
    • Owens, M.J.1    Morgan, W.N.2    Plott, S.J.3    Nemeroff, C.B.4
  • 34
    • 0026433037 scopus 로고
    • Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
    • Pacholczyk T, Blakely RD, Amara SG (1991) Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350:350-354.
    • (1991) Nature , vol.350 , pp. 350-354
    • Pacholczyk, T.1    Blakely, R.D.2    Amara, S.G.3
  • 35
    • 0028168407 scopus 로고
    • Reversal by imipramine of beta-adrenoceptor up-regulation induced in a chronic mild stress model of depression
    • Papp M, Nalepa I, Vetulani J (1994) Reversal by imipramine of beta-adrenoceptor up-regulation induced in a chronic mild stress model of depression. Eur J Pharmacol 261:141-147.
    • (1994) Eur J Pharmacol , vol.261 , pp. 141-147
    • Papp, M.1    Nalepa, I.2    Vetulani, J.3
  • 36
    • 0035134756 scopus 로고    scopus 로고
    • Differential expression of the noradrenaline transporter in adrenergic chromaffin cells, ganglion cells and nerve fibres of the rat adrenal medulla
    • Phillips JK, Dubey R, Sesiashvilvi E, Takeda M, Christie DL, Lipski J (2001) Differential expression of the noradrenaline transporter in adrenergic chromaffin cells, ganglion cells and nerve fibres of the rat adrenal medulla. J Chem Neuroanat 21:95-104.
    • (2001) J Chem Neuroanat , vol.21 , pp. 95-104
    • Phillips, J.K.1    Dubey, R.2    Sesiashvilvi, E.3    Takeda, M.4    Christie, D.L.5    Lipski, J.6
  • 37
    • 0023339694 scopus 로고
    • An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice
    • Pinkert CA, Ornitz DM, Brinster RL, Palmiter RD (1987) An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1:268-276.
    • (1987) Genes Dev , vol.1 , pp. 268-276
    • Pinkert, C.A.1    Ornitz, D.M.2    Brinster, R.L.3    Palmiter, R.D.4
  • 42
    • 0033232510 scopus 로고    scopus 로고
    • Role of norepinephrine in the pathophysiology and treatment of mood disorders
    • Ressler KJ, Nemeroff CB (1999) Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry 46:1219-1233.
    • (1999) Biol Psychiatry , vol.46 , pp. 1219-1233
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 43
    • 0033765025 scopus 로고    scopus 로고
    • Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
    • Ressler KJ, Nemeroff CB (2000) Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12:2-19.
    • (2000) Depress Anxiety , vol.12 , pp. 2-19
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 44
    • 0032712514 scopus 로고    scopus 로고
    • Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain
    • Sacchetti G, Bernini M, Bianchetti A, Parini S, Invernizzi RW, Samanin R (1999) Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. Br J Pharmacol 128:1332-1338.
    • (1999) Br J Pharmacol , vol.128 , pp. 1332-1338
    • Sacchetti, G.1    Bernini, M.2    Bianchetti, A.3    Parini, S.4    Invernizzi, R.W.5    Samanin, R.6
  • 45
    • 0028799622 scopus 로고
    • Cooperation by sterol regulatory element-binding protein and Spl in sterol regulation of low density lipoprotein receptor gene
    • Sanchez HB, Yieh L, Osborne TF (1995) Cooperation by sterol regulatory element-binding protein and Spl in sterol regulation of low density lipoprotein receptor gene. J Biol Chem 270:1161-1169.
    • (1995) J Biol Chem , vol.270 , pp. 1161-1169
    • Sanchez, H.B.1    Yieh, L.2    Osborne, T.F.3
  • 46
    • 0031690164 scopus 로고    scopus 로고
    • Regulation of a Purkinje cell-specific promoter by homeodomain proteins: Repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7
    • Sanlioglu S, Zhang X, Baader SL, Oberdick J (1998) Regulation of a Purkinje cell-specific promoter by homeodomain proteins: repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7. J Neurobiol 36:559-571.
    • (1998) J Neurobiol , vol.36 , pp. 559-571
    • Sanlioglu, S.1    Zhang, X.2    Baader, S.L.3    Oberdick, J.4
  • 48
    • 0029905502 scopus 로고    scopus 로고
    • Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene
    • Seo H, Yang C, Kim HS, Kim KS (1996) Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene. J Neurosci 16:4102-4112.
    • (1996) J Neurosci , vol.16 , pp. 4102-4112
    • Seo, H.1    Yang, C.2    Kim, H.S.3    Kim, K.S.4
  • 50
    • 0026655584 scopus 로고
    • A bifunctional genetic regulatory element of the rat dopamine beta-hydroxylase gene influences cell type specificity and second messenger-mediated transcription
    • Shaskus J, Greco D, Asnani LP, Lewis EJ (1992) A bifunctional genetic regulatory element of the rat dopamine beta-hydroxylase gene influences cell type specificity and second messenger-mediated transcription. J Biol Chem 267:18821-18830.
    • (1992) J Biol Chem , vol.267 , pp. 18821-18830
    • Shaskus, J.1    Greco, D.2    Asnani, L.P.3    Lewis, E.J.4
  • 51
    • 0027471464 scopus 로고
    • A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice
    • Simonet WS, Bucay N, Lauer SJ, Taylor JM (1993) A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J Biol Chem 268:8221-8229.
    • (1993) J Biol Chem , vol.268 , pp. 8221-8229
    • Simonet, W.S.1    Bucay, N.2    Lauer, S.J.3    Taylor, J.M.4
  • 52
    • 0024845321 scopus 로고
    • Progressive restriction in the distribution of the Hox-1.3 homeodomain protein during embryogenesis
    • Tani M, Odenwald WF, Lazzarini RA, Friedrich Jr VL (1989) Progressive restriction in the distribution of the Hox-1.3 homeodomain protein during embryogenesis. J Neurosci Res 24:457-469.
    • (1989) J Neurosci Res , vol.24 , pp. 457-469
    • Tani, M.1    Odenwald, W.F.2    Lazzarini, R.A.3    Friedrich Jr., V.L.4
  • 53
    • 0029958253 scopus 로고    scopus 로고
    • The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
    • Tiveron MC, Hirsch MR, Brunet JF (1996) The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system. J Neurosci 16:7649-7660.
    • (1996) J Neurosci , vol.16 , pp. 7649-7660
    • Tiveron, M.C.1    Hirsch, M.R.2    Brunet, J.F.3
  • 54
    • 0027489411 scopus 로고
    • The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
    • Valarche I, Tissier-Seta JP, Hirsch MR, Martinez S, Goridis C, Brunet JF (1993) The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development 119:881-896.
    • (1993) Development , vol.119 , pp. 881-896
    • Valarche, I.1    Tissier-Seta, J.P.2    Hirsch, M.R.3    Martinez, S.4    Goridis, C.5    Brunet, J.F.6
  • 56
    • 0031666552 scopus 로고    scopus 로고
    • Identification and characterization of potential cis-regulatory elements governing transcriptional activation of the rat tyrosine hydroxylase gene
    • Yang C, Kim HS, Seo H, Kim KS (1998a) Identification and characterization of potential cis-regulatory elements governing transcriptional activation of the rat tyrosine hydroxylase gene. J Neurochem 71:1358-1368.
    • (1998) J Neurochem , vol.71 , pp. 1358-1368
    • Yang, C.1    Kim, H.S.2    Seo, H.3    Kim, K.S.4
  • 57
    • 0031752431 scopus 로고    scopus 로고
    • Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene
    • Yang C, Kim HS, Seo H, Kim CH, Brunet JF, Kim KS (1998b) Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene. J Neurochem 71:1813-1826.
    • (1998) J Neurochem , vol.71 , pp. 1813-1826
    • Yang, C.1    Kim, H.S.2    Seo, H.3    Kim, C.H.4    Brunet, J.F.5    Kim, K.S.6
  • 58
    • 0029583123 scopus 로고
    • A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes
    • Zellmer E, Zhang Z, Greco D, Rhodes J, Cassel S, Lewis EJ (1995) A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes. J Neurosci 15:8109-8120.
    • (1995) J Neurosci , vol.15 , pp. 8109-8120
    • Zellmer, E.1    Zhang, Z.2    Greco, D.3    Rhodes, J.4    Cassel, S.5    Lewis, E.J.6
  • 59
    • 0029917042 scopus 로고    scopus 로고
    • Functional dissection of the mouse Hox-a5 gene
    • Zhao JJ, Lazzarini RA, Pick L (1996) Functional dissection of the mouse Hox-a5 gene. EMBO J 15:1313-1322.
    • (1996) EMBO J , vol.15 , pp. 1313-1322
    • Zhao, J.J.1    Lazzarini, R.A.2    Pick, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.