A Proximal Promoter Domain Containing a Homeodomain-Binding Core Motif Interacts with Multiple Transcription Factors, Including HoxA5 and Phox2 Proteins, and Critically Regulates Cell Type-Specific Transcription of the Human Norepinephrine Transporter Gene

Journal of Neuroscience

Volumn 22, Issue 7, 2002, Pages 2579-2589

  Kim, Chun Hyung ^a   Hwang, Dong Youn ^a   Park, Jae Joon ^a   Kim, Kwang Soo ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell type specific transcription; Cis acting element; Homeodomain; HoxA5; Noradrenergic neuron; Norepinephrine transporter; Phox2a; Promoter

Indexed keywords

DEOXYRIBONUCLEASE I; DOPAMINE BETA MONOOXYGENASE; HOMEODOMAIN PROTEIN; NORADRENALIN TRANSPORTER; PROTEIN FACTOR; PROTEIN HOXA5; PROTEIN PHOX2A; UNCLASSIFIED DRUG; COTRANSPORTER; HOXA5 PROTEIN, HUMAN; NERVE PROTEIN; PHOSPHOPROTEIN; PHOX2A PROTEIN, HUMAN; SLC6A2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; ASSAY; CELL SPECIFICITY; CONTROLLED STUDY; DNA FOOTPRINTING; ENHANCER REGION; ENZYME ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NERVE CELL; NEUROBLASTOMA CELL; NORADRENERGIC NERVE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPORTER GENE; SILENCER GENE; TRANSACTIVATION; 5' UNTRANSLATED REGION; ANTIBODY SPECIFICITY; CELL LINE; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REGULATOR GENE; REGULATORY SEQUENCE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

5' UNTRANSLATED REGIONS; AMINO ACID MOTIFS; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, REGULATOR; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ORGAN SPECIFICITY; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; REGULATORY SEQUENCES, NUCLEIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0036551206     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-07-02579.2002     Document Type: Article

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