A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type- specific expression of the human norepinephrine transporter gene

Journal of Biological Chemistry

Volumn 274, Issue 10, 1999, Pages 6507-6518

  Kim, Chun Hyung ^a   Kim, Hee Sun ^a   Cubells, Joseph F ^b   Kim, Kwang Soo ^a,c  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; NORADRENALIN;

ARTICLE; CASE REPORT; CELL SPECIFICITY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE ISOLATION; GENE SEQUENCE; HUMAN; HUMAN CELL; INTRON; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSACTIVATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CARRIER PROTEINS; DNA, COMPLEMENTARY; GENOME, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ORGAN SPECIFICITY; SYMPORTERS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033525881     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.10.6507     Document Type: Article

References (71)

1. Axelrod, J., and Kopin, I. J. (1969) Prog. Brain Res. 31, 21-32
2. Schildkraut, J. J. (1965) Am. J. Psychiatry 122, 509-522
3. Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H. Y., Kalka, S., Dilley, G., and Ordway, G. A. (1997) J. Neurosci. 17, 8451-8458
4. Giros, B., and Caron, M. G. (1993) Trends Pharmacol. Sci. 14, 43-49
5. Fritz, J. D., Jayanthi, L. D., Thoreson, M. A., and Blakely, R. D. (1998) J. Neurochem. 70, 2241-2251
6. Markel, P. D., Bennett, B., Beeson, M., Gordon, L., Simpson, V. J., and Johnson, T. E. (1996) Mamm. Genome 7, 408-412
7. Markel, P. D., Bennett, B., Beeson, M., Gordon, L., and Johnson, T. E. (1997) Genome Res. 7, 92-99
8. Israel, Y., Carmichael, F. J., and Macdonald, J. A. (1973) Ann. N. Y. Acad. Sci. 215, 38-48
9. Lin, A. M. Y., Bickford, P. C., Palmer, M. R., and Gerhardt, G. A. (1993) Neurosci. Lett. 164, 71-75
10. Pacholczyk, T., Blakely, R. D., and Amara, S. G. (1991) Nature 350, 350-354
11. Lingen, B., Brass, M., and Bonisch, H. (1994) FEBS Lett. 342, 235-238
12. Bruss, M., Porzgen, P., Bryan-Lluka, L. J., and Bonisch, H. (1997) Mol. Brain Res. 52, 257-262
13. Amara, S. G., Sonders, M. S., Zahniser, N. R., Povlock, S. L., and Daniels, G. M. (1998) Adv. Pharmacol. 42, 164-168
14. Amara, S. G., and Kuhar, M. J. (1993) Annu. Rev. Neurosci. 16, 73-93
15. Barker, E. L., and Blakely, R. D. (1995) in Psychopharmacology: The Fourth Generation of Progress (Bloom, F. E., and Kupfer, D. J., eds) pp. 321-333, Raven Press, Ltd., New York
16. Uhl, G. R. (1992) Trends Neurosci. 15, 265-268
17. Porzgen, P., Bonisch, H., and Bruss, M. (1995) Biochem. Biophys. Res. Commun. 215, 1145-1150
18. Lorang, D., Amara, S. G., and Simerly, R. B. (1994) J. Neurosci. 14, 4903-4914
19. Kirshner, N., and Goodall, M. (1957) J. Biol. Chem. 226, 207-212
20. Friedman, S., and Kaufman, S. (1965) J. Biol. Chem. 240, 4763-4773
21. Cubells, J. F., Kim, K. S., Baker, H., Volpe, B. T., Chung, Y., Houpt, T. A., Wessel, T. C., and Joh, T. H. (1995) J. Neurochem. 65, 502-509
22. Wakade, A. R., Wakade, T. D., Poosch, M., and Bannon, M. J. (1996) J. Physiol. (Lond.)494, 67-75
23. Matsuoka, I., Kumagai, M., and Kurihara, K. (1997) Brain. Res. 776, 181-188
24. Lu, D., Yu, K., Paddy, M. R., Rowland, N. E., and Raizada, M. K. (1996) Endocrinology 137, 763-772
25. Bonisch, H., Hammermann, R., and Brass, M. (1998) Adv. Pharmacol. 42, 183-186
26. Kim, H. S., Seo, H., Brunet, J. F., and Kim, K. S. (1998) J. Neurosci. 18, 8247-8260
27. Yang, C., Kim, H. S., Seo, H., Kim, C. H., Brunet, J. F., and Kim, K. S. (1998) J. Neurochem. 71, 1813-1826
28. Kim, K. S., Ishiguro, H., Tinti, C., Wagner, J., and Job, T. H. (1994) J. Neurosci. 14, 7200-7207
29. Ishiguro, H., Kim, K. T., Joh, T. H., and Kim, K. S. (1993) J. Biol. Chem. 268, 17987-17994
30. Suri, C., Fung, B. P., Tischler, A. S., and Chikaraishi, D. M. (1993) J. Neurosci. 13, 1280-1291
31. Ross, R. A., Biedler, J. L., Spengler, B. A., and Reis, D. J. (1981) Cell. Mol. Neurobiol. 1, 301-311
32. Kim, K. S., Febraio, M., Han, T. H., Wessel, T. C., Park, D. H., and Joh, T. H. (1995) in A Practical Approach: Gene Probes 2 (Rickwood, D., And Hames, B. D., eds) pp. 151-182, Oxford University Press, Oxford
33. Frohman, M. A., Dush, M. K., and Martin, G. R. (1988) Proc. Natl. Acad. Sci. U. S. A. 86, 8998-9002
34. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
35. Kim, K. S., Tinti, C., Song, B., Cubells, J. F., and Joh, T. H. (1994) J. Neurochem. 63, 834-842
36. Luckow, B., and Schutz, G. (1987) Nucleic. Acids Res. 15, 5490
37. Hoyle, G. W., Mercer, E. H., Palmiter, R. D., and Brinster, R. L. (1994) J. Neurosci. 14, 2455-2463
38. Seo, H., Yang, C., Kim, H. S., and Kim, K. S. (1996) J. Neurosci. 16, 4102-4112
39. Breathnach, R., and Chambon, P. (1981) Annu. Rev. Biochem. 50, 349-383
40. Hirzmann, J., Luo, D., Hahnen, J., and Hobom, G. (1993) Nucleic Acids Res. 21, 3597-3598
41. Bengel, D., Heils, A., Petri, S., Seemann, M., Glatz, K., Andrews, A., Murphy, D. L., and Lesch, K. P. (1997) Mol. Brain. Res. 44, 286-292
42. Bradley, C. C., and Blakely, R. D. (1997) J. Neurochem. 69, 1356-1367
43. Donovan, D. M., Vandenbergh, D. J., Perry, M. P., Bird, G. S., Ingersoll, R., Nanthakumar, E., and Uhl, G. R. (1995) Mol. Brain Res. 30, 327-335
44. Kawarai, T., Kawakami, H., Yamamura, Y., and Nakamura, S. (1997) Gene (Amst.)195, 11-18
45. Kraner, S. D., Chong, J. A., Tsay, H. J., and Mandel, G. (1992) Neuron 9, 37-44
46. Mori, N., Schoenherr, C., Vandenbergh, D. J., and Anderson, D. J. (1992) Neuron 9, 45-54
47. Schoenherr, C. J., Paquette, A. J., and Andersen, D. J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9881-9886
48. Morin, X., Cremer, H., Hirsch, M. R., Kapur, R. P., Goridis, C., and Brunet, J. F. (1997) Neuron 18, 411-423
49. Porzgen, P., Bonisch, H., Hammermann, R., and Brass, M. (1998) Biochim. Biophys. Acta 1398, 365-370
50. Ramamoorthy, S., Prasad, P. D., Kulanthaivel, P., Leibach, F. H., Blakely, R. D., and Ganapathy, V. (1993) Biochemistry 32, 1346-1353
51. Greene, L. A., and Tischler, A. S. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 2424-2428
52. Ciccarone, V., Spengler, B. A., Meyers, M. B., Biedler, J. L., and Ross, R. A. (1989) Cancer Res. 49, 219-225
53. Mercer, E. H., Hoyle, G. W., Kapur, R. P., Brinster, R. L., and Palmiter, R. D. (1991) Neuron 7, 703-716
54. Kobayashi, K., Morita, S., Mizuguchi, T., Sawada, H., Yamada, K., Nagatsu, I., Fujuta, K., and Nagatsu, T. (1994) J. Biol. Chem. 269, 29725-29731
55. Kobayashi, K., Sasaoka, T., Morita, S., Nagatsu, I., Iguchi, A., Kurosawa, Y., Fujita, K., Nomura, T., Kimura, M., Katsuki, M., and Nagatsu, T. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1631-1635
56. Morita, S., Kobayashi, K., Mizuguchi, T., Yamada, K., Nagatsu, I., Titani, K., Fujita, K., Hidaka, H., and Nagatsu, T. (1993) Mol. Brain Res. 17, 239-244
57. Shaskus, J., Greco, D., Asnani, L. P., and Lewis, E. J. (1992) J. Biol. Chem. 267, 18821-18830
58. Hormuzdi, S. G., Penttinen, R., Jaenisch, R., and Bornstein, P. (1998) Mol. Cell. Biol. 18, 3368-3375
59. Smith, A. F., Bigsby, R. M., Word, R. A., and Herring, B. P. (1998)Am. J. Physiol. 274, C1188-C1195
60. Valarche, I., Jean-Philippe, T.-S., Marie-Rose, H., Salvador, M., Christo, G., and Brunet J. F. (1993) Development 119, 881-896
61. Tiveron, M. C., Hirsch, M. R., and Brunet, J. F. (1996) J. Neurosci. 16, 7649-7660
62. Reis, D. J., Joh, T. H., Ross, R. A., and Pickel, V. M. (1974) Brain Res. 81, 380-386
63. Reis, D. J., Joh, T. H., and Ross, R. A. (1975) J. Pharmacol. Exp. Ther. 193, 775-784
64. McMahon, A., Geertman, R., and Sabban, E. L. (1990) J. Neurosci. Res. 26, 395-404
65. Cubells, J. F., Baker, H., Volpe, B. T., Smith, G. P., Das, S. S., and Joh, T. H. (1995) Neurosci. Lett. 193, 189-192
66. Kim, K. T., Park, D. H., and Joh, T. H. (1993) J. Neurochem. 60, 946-951
67. Faisst, S., and Meyer, S. (1992) Nucleic Acids Res. 20, 3-26
68. Goodman, R. H. (1990) Annu. Rev. Neurosci. 13, 111-127
69. Jones, K. A., and Tjian, R. (1985) Nature 317, 179-182
70. Rajavashisth, T. B., Taylor, A. K., Andalibi, A., Svenson, K. L., and Lusis, A. J. (1969) Science 245, 640-643
71. Roesler, W. J., Vandenbark, G. R., and Hanson, R. W. (1988) J. Biol. Chem. 263, 9063-9066