Knowing left from right: The molecular basis of laterality defects

Molecular Medicine Today

Volumn 6, Issue 3, 2000, Pages 112-118

  Capdevila, Javier ^a   Belmonte, Juan Carlos Izpisúa ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHICK EMBRYO; CONGENITAL MALFORMATION; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HUMAN; NONHUMAN; ORGANOGENESIS; REVIEW;

MAMMALIA; VERTEBRATA;

EID: 10844256615     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(00)01671-3     Document Type: Review

References (81)

1. Merklin R.J., Varano N.R. Situs inversus and cardiac defects. A study of 111 cases of reversed asymmetry. J. Thorac. Cardiovasc. Surg. 44:1995;1-110.
2. Bowers P.N.et al. The genetics of left-right development and heterotaxia. Semin. Perinatol. 20:1996;577-588.
3. Splitt M.P.et al. Defects in the determination of left-right asymmetry. J. Med. Genet. 33:1996;498-503.
4. Nakada K.et al. Digestive tract disorders associated with asplenia/polysplenia syndrome. J. Pediatr. Surg. 32:1997;91-94.
5. Burn J. Disturbance of morphological laterality in humans. Bock G.R., Marsh J. Biological Asymmetry and Handedness (Vol. 162). 1991;282-299 John Wiley & Sons, New York. Ciba Foundation Symposium.
6. Bowers P.N.et al. Laterality disturbances. Prog. Pediatr. Cardiol. 6:1996;53-62.
7. Anderson R.H.et al. Defective lateralisation in children with congenitally malformed hearts. Cardiol. Young. 8:1998;512-531.
8. Levin M.et al. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell. 82:1995;803-814.
9. Wood W.B. Left-right asymmetry in animal development. Annu. Rev. Cell. Dev. Biol. 13:1997;53-82.
10. Harvey R.P. Cardiac looping - an uneasy deal with laterality. Semin. Cell. Dev. Biol. 9:1998;101-108.
11. Ramsdell A.F., Yost H.J. Molecular mechanisms of vertebrate left-right development. Trends Genet. 14:1998;459-465.
12. Stern C.D.et al. Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. Dev. Biol. 172:1995;192-205.
13. Levin M. Left-right asymmetry in vertebrate embryogenesis. Bioessays. 19:1997;287-296.
14. Boettger T.et al. FGF-8 functions in the specification of the right body side of the chick. Curr. Biol. 9:1999;277-280.
15. Rodriguez Esteban C.et al. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature. 401:1999;243-251.
16. Yokouchi Y.et al. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Cell. 98:1999;573-583.
17. Zhu L.et al. Cerberus regulates left-right asymmetry of the embryonic head and heart. Curr. Biol. 9:1999;931-938.
18. Logan M.et al. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell. 94:1998;307-317.
19. Piedra M.E.et al. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell. 94:1998;319-324.
20. Ryan A.K.et al. Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature. 394:1998;545-551.
21. St Amand T.R.et al. Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping. Biochem. Biophys. Res. Commun. 247:1998;100-105.
22. Yoshioka H.et al. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell. 94:1998;299-305.
23. Campione M.et al. The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development. 126:1999;1225-1234.
24. Isaac A.et al. Control of vertebrate left-right asymmetry by a snail-related zinc finger gene. Science. 275:1997;1301-1304.
25. Patel K.et al. Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left-right asymmetry. Curr. Biol. 9:1999;609-612.
26. Meno C.et al. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 94:1998;287-297.
27. Chazaud C.et al. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development. 126:1999;2589-2596.
28. -/- mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U. S. A. 96:1999;11376-11381.
29. Hyatt B.A., Yost H.J. The left-right coordinator: the role of Vg1 in organizing left-right axis formation. Cell. 93:1998;37-46.
30. Brown N.A., Wolpert L. The development of handedness in left/right asymmetry. Development. 109:1990;1-9.
31. Levin M., Mercola M. Gap junctions are involved in the early generation of left-right asymmetry. Dev. Biol. 203:1998;90-105.
32. Afzelius B.A. A human syndrome caused by immotile cilia. Science. 193:1976;317-319.
33. Afzelius B.A. Situs inversus and ciliary abnormalities. What is the connection? Int. J. Dev. Biol. 39:1995;839-844.
34. Sulik K.et al. Morphogenesis of the murine node and notochordal plate. Dev. Dyn. 201:1994;260-278.
35. Supp D.M.et al. Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature. 389:1997;963-966.
36. Nonaka S.et al. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell. 95:1998;829-837.
37. Okada Y.et al. Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol. Cell. 4:1999;459-468.
38. Schneider A.et al. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr. Biol. 9:1999;911-914.
39. Yokoyama T.et al. Reversal of left-right asymmetry: a situs inversus mutation. Science. 260:1993;679-682.
40. Mochizuki T.et al. Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature. 395:1998;177-181.
41. Morgan D.et al. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse. Nat. Genet. 20:1998;149-156.
42. Pagan-Westphal S.M., Tabin C.J. The transfer of left-right positional information during chick embryogenesis. Cell. 93:1998;25-35.
43. Levin M., Nascone N. Two molecular models of initial left-right asymmetry generation. Med. Hypotheses. 49:1997;429-435.
44. Cooke J. Vertebrate left and right: finally a cascade, but first a flow? Bioessays. 21:1999;537-541.
45. Collignon J.et al. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature. 381:1996;155-158.
46. Lowe L.A.et al. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature. 381:1996;158-161.
47. Levin M.et al. Laterality defects in conjoined twins. Nature. 384:1996;321.
48. Semina E.V.et al. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat. Genet. 14:1996;392-399.
49. Gage P.J.et al. Dosage requirement of Pitx2 for development of multiple organs. Development. 126:1999;4643-4651.
50. Lin C.R.et al. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature. 401:1999;279-282.
51. Lu M.F.et al. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature. 401:1999;276-278.
52. Kitamura K.et al. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development. 126:1999;5749-5758.
53. Chen J.N.et al. left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development. 124:1997;4373-4382.
54. Mercola M. Embryological basis for cardiac left-right asymmetry. Semin. Cell Dev. Biol. 10:1999;109-116.
55. Tsuda T.et al. Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stages. Dev. Genet. 23:1998;203-214.
56. Smith S.M.et al. Retinoic acid directs cardiac laterality and the expression of early markers of precardiac asymmetry. Dev. Biol. 182:1997;162-171.
57. Linask K.K., Lash J.W. A role for fibronectin in the migration of avian precardiac cells. I. Dose dependent effects of fibronectin antibody. Dev. Biol. 129:1988;315-323.
58. Yost H.J. Regulation of vertebrate left-right asymmetries by extracellular matrix. Nature. 357:1992;158-161.
59. Sacks L.V., Rifkin I.R. Mirror image arrangement of the abdominal organs with a left-sided morphologically normal heart. Br. Heart J. 58:1987;534-536.
60. Akel S.et al. Abdominal situs inversus with congenital duodenal stenosis: rare association. Eur. J. Pediatr. Surg. 8:1998;55-57.
61. Litingtung Y.et al. Sonic hedgehog is essential to foregut development. Nat. Genet. 20:1998;58-61.
62. Izraeli S.et al. The SIL gene is required for mouse embryonic axial development and left-right specification. Nature. 399:1999;691-694.
63. Meyers E.N., Martin G.R. Differences in left-right axis pathways in mouse and chick: functions of FGF-8 and SHH. Science. 285:1999;403-406.
64. Tkebuchava T.et al. Kartagener's syndrome: clinical presentation and cardiosurgical aspects. Ann. Thorac. Surg. 62:1996;1474-1479.
65. Tkebuchava T.et al. Cardiac surgery for Kartagener syndrome. Pediatr. Cardiol. 18:1997;72-73.
66. Berdat P.A.et al. Successful heart transplantation in a patient with Ivemark syndrome combined with situs inversus, single atrium and ventricle after total cavo-pulmonary connection. Eur. J. Cardio-thorac. Surg. 14:1998;631-634.
67. Chang J.et al. Intestinal rotation and fixation abnormalities in heterotaxia: early detection and management. J. Pediatr. Surg. 28:1993;1281-1284.
68. Meno C.et al. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell. 4:1999;287-298.
69. Saijoh Y.et al. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell. 2000;. (in press).
70. Schweickert A.et al. Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. Mech. Dev. 90:2000;41-51.
71. Oh S.P., Li E. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11:1997;1812-1826.
72. King T.et al. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech. Dev. 79:1998;29-37.
73. Chen J.et al. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest. 102:1998;1077-1082.
74. -/- mice analysis. J. Cell Biol. 145:1999;825-836.
75. Marszalek J.R.et al. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5043-5048.
76. Izraeli S.et al. Expression of the SIL gene is correlated with growth induction and cellular proliferation. Cell Growth Differ. 8:1997;1171-1179.
77. Kosaki R.et al. Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am. J. Med. Genet. 82:1999;70-76.
78. Kosaki K.et al. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Am. J. Hum. Genet. 64:1999;712-721.
79. Gebbia M.et al. X-linked situs abnormalities result from mutations in ZIC3. Nat. Genet. 17:1997;305-308.
80. Ferrero G.B.et al. A submicroscopic deletion in Xq26 associated with familial situs ambiguus. Am. J. Hum. Genet. 61:1997;395-401.
81. Supp D.M.et al. Handed asymmetry in the mouse: understanding how things go right (or left) by studying how they go wrong. Semin. Cell. Dev. Biol. 9:1998;77-87.