-
1
-
-
0023690307
-
Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion
-
Goldman JM, Gale RP, Horowitz MM, Biggs JC, Champlin RE, Gluckman E, Hoffmann RG, Jacobsen SJ, Marmont AM, McGlave PB, Soegiarso W, Brodsky I: Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann Intern Med 108:806, 1988
-
(1988)
Ann Intern Med
, vol.108
, pp. 806
-
-
Goldman, J.M.1
Gale, R.P.2
Horowitz, M.M.3
Biggs, J.C.4
Champlin, R.E.5
Gluckman, E.6
Hoffmann, R.G.7
Jacobsen, S.J.8
Marmont, A.M.9
McGlave, P.B.10
Soegiarso, W.11
Brodsky, I.12
-
2
-
-
0030901273
-
Biology and treatment of chronic myeloid leukemia
-
Jones RJ: Biology and treatment of chronic myeloid leukemia. Curr Opin Oncol 9:3, 1997
-
(1997)
Curr Opin Oncol
, vol.9
, pp. 3
-
-
Jones, R.J.1
-
3
-
-
0030049281
-
Biology and treatment of adult acute lymphoblastic leukemia
-
Levitt L, Lin R: Biology and treatment of adult acute lymphoblastic leukemia. West J Med 164:143, 1996
-
(1996)
West J Med
, vol.164
, pp. 143
-
-
Levitt, L.1
Lin, R.2
-
4
-
-
0028115696
-
Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation
-
Attal M, Canal P, Schlaifer D, Chatelut E, Dezeuze A, Huguet F, Payen C, Pris J, Laurent G: Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation. J Clin Oncol 12:141, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 141
-
-
Attal, M.1
Canal, P.2
Schlaifer, D.3
Chatelut, E.4
Dezeuze, A.5
Huguet, F.6
Payen, C.7
Pris, J.8
Laurent, G.9
-
5
-
-
0028072670
-
Update of results of autologous bone marrow transplantation in lymphoma
-
Bierman PJ: Update of results of autologous bone marrow transplantation in lymphoma. Med Oncol 11:35, 1994
-
(1994)
Med Oncol
, vol.11
, pp. 35
-
-
Bierman, P.J.1
-
6
-
-
0030927544
-
Bone marrow transplantation for low-grade B-cell malignancies
-
Gribben JG: Bone marrow transplantation for low-grade B-cell malignancies. Curr Opin Oncol 9:117, 1997
-
(1997)
Curr Opin Oncol
, vol.9
, pp. 117
-
-
Gribben, J.G.1
-
7
-
-
0027057695
-
High-dose carmustine, etoposide, and cisplatin and autologous bone marrow transplantation for relapsed and refractory lymphoma
-
Lazarus HM, Crilley P, Ciobanu N, Creger RJ, Fox RM, Shina DC, Bulova SI, Gucalp R, Cooper BW, Topolsky D, Messner HA, Rimm AA, Rozman C, Speck B, Tura S, Weiner RS, Bortin MM: High-dose carmustine, etoposide, and cisplatin and autologous bone marrow transplantation for relapsed and refractory lymphoma. J Clin Oncol 10:1682, 1992
-
(1992)
J Clin Oncol
, vol.10
, pp. 1682
-
-
Lazarus, H.M.1
Crilley, P.2
Ciobanu, N.3
Creger, R.J.4
Fox, R.M.5
Shina, D.C.6
Bulova, S.I.7
Gucalp, R.8
Cooper, B.W.9
Topolsky, D.10
Messner, H.A.11
Rimm, A.A.12
Rozman, C.13
Speck, B.14
Tura, S.15
Weiner, R.S.16
Bortin, M.M.17
-
8
-
-
0028225488
-
Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in refractory lymphoma patients undergoing autologous bone marrow transplantation
-
Schlaifer D, Attal M, Huguet F, Canal P, Laurent G, Pris J: Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in refractory lymphoma patients undergoing autologous bone marrow transplantation. Semin Hematol 31:31, 1994
-
(1994)
Semin Hematol
, vol.31
, pp. 31
-
-
Schlaifer, D.1
Attal, M.2
Huguet, F.3
Canal, P.4
Laurent, G.5
Pris, J.6
-
9
-
-
0028172929
-
Carmustine, Ara C, cyclophosphamide and etoposide with autologous bone marrow transplantation in relapsed or refractory lymphoma: A dose-finding study
-
Snyder MJ, Johnson DB, Daly MB, Giguere JK, Harman GH, Harden EA, Johnson RA, Leff RS, Mercier RJ, Messerschmidt GL, Rubinsak JR, Essell JH, Halvorson RD, Thompson JM: Carmustine, Ara C, cyclophosphamide and etoposide with autologous bone marrow transplantation in relapsed or refractory lymphoma: A dose-finding study. Bone Marrow Transplant 14:595, 1994
-
(1994)
Bone Marrow Transplant
, vol.14
, pp. 595
-
-
Snyder, M.J.1
Johnson, D.B.2
Daly, M.B.3
Giguere, J.K.4
Harman, G.H.5
Harden, E.A.6
Johnson, R.A.7
Leff, R.S.8
Mercier, R.J.9
Messerschmidt, G.L.10
Rubinsak, J.R.11
Essell, J.H.12
Halvorson, R.D.13
Thompson, J.M.14
-
10
-
-
0028020285
-
Autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma and CNS involvement: Those transplanted with active CNS disease have a poor outcome - A report by the European Bone Marrow Transplant Lymphoma Registry
-
Williams CD, Pearce R, Taghipour G, Green ES, Philip T, Goldstone AH: Autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma and CNS involvement: Those transplanted with active CNS disease have a poor outcome - A report by the European Bone Marrow Transplant Lymphoma Registry. J Clin Oncol 12:2415, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 2415
-
-
Williams, C.D.1
Pearce, R.2
Taghipour, G.3
Green, E.S.4
Philip, T.5
Goldstone, A.H.6
-
11
-
-
0030959109
-
Bone marrow transplantation for inherited diseases
-
O'Marcaigh AS, Cowan MJ: Bone marrow transplantation for inherited diseases. Curr Opin Oncol 9:126, 1997
-
(1997)
Curr Opin Oncol
, vol.9
, pp. 126
-
-
O'Marcaigh, A.S.1
Cowan, M.J.2
-
12
-
-
0030762736
-
Recent advances in graft-versus-host disease (GVHD) prevention
-
Blazar BR, Korngold R, Vallera DA: Recent advances in graft-versus-host disease (GVHD) prevention. Immunol Rev 157:79, 1997
-
(1997)
Immunol Rev
, vol.157
, pp. 79
-
-
Blazar, B.R.1
Korngold, R.2
Vallera, D.A.3
-
13
-
-
0029552564
-
Prevention and treatment of graft-versus-host disease
-
Chao NJ, Schlegel PG: Prevention and treatment of graft-versus-host disease. Ann NY Acad Sci 770:130, 1995
-
(1995)
Ann NY Acad Sci
, vol.770
, pp. 130
-
-
Chao, N.J.1
Schlegel, P.G.2
-
14
-
-
0030934464
-
Prevention and treatment of acute graft-versus-host disease: The old and the new. A report from the Eastern Cooperative Oncology Group (ECOG)
-
Lazarus HM, Vogelsang GB, Rowe JM: Prevention and treatment of acute graft-versus-host disease: The old and the new. A report from the Eastern Cooperative Oncology Group (ECOG). Bone Marrow Transplant 19:577, 1997
-
(1997)
Bone Marrow Transplant
, vol.19
, pp. 577
-
-
Lazarus, H.M.1
Vogelsang, G.B.2
Rowe, J.M.3
-
16
-
-
0030640316
-
Graft-versus-host disease: Implications from basic immunology for prophylaxis and treatment
-
Vogelsang GB: Graft-versus-host disease: Implications from basic immunology for prophylaxis and treatment. Cancer Treat Res 77:87, 1997
-
(1997)
Cancer Treat Res
, vol.77
, pp. 87
-
-
Vogelsang, G.B.1
-
17
-
-
0029027351
-
Identification of a graft versus host disease-associated human minor histocompatibility antigen
-
den Haan JM, Sherman NE, Blokland E, Huczko E, Koning F, Drijfhout JW, Skipper J, Shabanowitz J, Hunt DF, Engelhard VH, Goulmy E: Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science 268:1476, 1995
-
(1995)
Science
, vol.268
, pp. 1476
-
-
Haan, J.M.1
Sherman, N.E.2
Blokland, E.3
Huczko, E.4
Koning, F.5
Drijfhout, J.W.6
Skipper, J.7
Shabanowitz, J.8
Hunt, D.F.9
Engelhard, V.H.10
Goulmy, E.11
-
18
-
-
0028483262
-
Lymphocyte-mediated cytotoxicity: Two pathways and multiple killer molecules
-
Henkart PA: Lymphocyte-mediated cytotoxicity: Two pathways and multiple killer molecules. Immunity 1:343, 1994
-
(1994)
Immunity
, vol.1
, pp. 343
-
-
Henkart, P.A.1
-
19
-
-
0030823702
-
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
-
Graubert TA, DiPersio JF, Russell JH, Ley TJ: Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100:904, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 904
-
-
Graubert, T.A.1
DiPersio, J.F.2
Russell, J.H.3
Ley, T.J.4
-
20
-
-
0030984020
-
CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients
-
Blazar BR, Taylor PA, Vallera DA: CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients. Transplantation 64:571, 1997
-
(1997)
Transplantation
, vol.64
, pp. 571
-
-
Blazar, B.R.1
Taylor, P.A.2
Vallera, D.A.3
-
21
-
-
0029953810
-
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
-
Baker MB, Altman NH, Podack ER, Levy RB: The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J Exp Med 183:2645, 1996
-
(1996)
J Exp Med
, vol.183
, pp. 2645
-
-
Baker, M.B.1
Altman, N.H.2
Podack, E.R.3
Levy, R.B.4
-
22
-
-
0030293633
-
Differential effect of CTLA4-Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD
-
Via CS, Rus V, Nguyen P, Linsley P, Gause WC: Differential effect of CTLA4-Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD. J Immunol 157:4258, 1996
-
(1996)
J Immunol
, vol.157
, pp. 4258
-
-
Via, C.S.1
Rus, V.2
Nguyen, P.3
Linsley, P.4
Gause, W.C.5
-
23
-
-
0030825407
-
Chemokines
-
Rollins BJ: Chemokines. Blood 90:909, 1997
-
(1997)
Blood
, vol.90
, pp. 909
-
-
Rollins, B.J.1
-
24
-
-
0028811280
-
Chemokines: New ligands, receptors and activities
-
Kunkel SL, Stricter RM, Lindley IJ, Westwick J: Chemokines: New ligands, receptors and activities. Immunol Today 16:559, 1995
-
(1995)
Immunol Today
, vol.16
, pp. 559
-
-
Kunkel, S.L.1
Stricter, R.M.2
Lindley, I.J.3
Westwick, J.4
-
25
-
-
0029895182
-
The chemokines: Cytokines that direct leukocyte migration
-
Negus RP: The chemokines: Cytokines that direct leukocyte migration. J R Soc Med 89:312, 1996
-
(1996)
J R Soc Med
, vol.89
, pp. 312
-
-
Negus, R.P.1
-
26
-
-
0028136769
-
Chemokines, inflammation and the immune system
-
Taub DD, Oppenheim JJ: Chemokines, inflammation and the immune system. Ther Immunol 1:229, 1994
-
(1994)
Ther Immunol
, vol.1
, pp. 229
-
-
Taub, D.D.1
Oppenheim, J.J.2
-
28
-
-
0029954523
-
Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells
-
Campbell JJ, Qin S, Bacon KB, Mackay CR, Butcher EC: Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J Cell Biol 134:255, 1996
-
(1996)
J Cell Biol
, vol.134
, pp. 255
-
-
Campbell, J.J.1
Qin, S.2
Bacon, K.B.3
Mackay, C.R.4
Butcher, E.C.5
-
29
-
-
0029045539
-
Chemokines, a family of chemotactic cytokines
-
Graves DT, Jiang Y: Chemokines, a family of chemotactic cytokines. Crit Rev Oral Biol Med 6:109, 1995
-
(1995)
Crit Rev Oral Biol Med
, vol.6
, pp. 109
-
-
Graves, D.T.1
Jiang, Y.2
-
30
-
-
0030056856
-
The role of MIP-1 alpha in inflammation and hematopoiesis
-
Cook DN: The role of MIP-1 alpha in inflammation and hematopoiesis. J Leukoc Biol 59:61, 1996
-
(1996)
J Leukoc Biol
, vol.59
, pp. 61
-
-
Cook, D.N.1
-
31
-
-
0028979682
-
Requirement of MIP-1α for an inflammatory response to viral infection
-
Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, Smithies O: Requirement of MIP-1α for an inflammatory response to viral infection. Science 269:1583, 1995
-
(1995)
Science
, vol.269
, pp. 1583
-
-
Cook, D.N.1
Beck, M.A.2
Coffman, T.M.3
Kirby, S.L.4
Sheridan, J.F.5
Pragnell, I.B.6
Smithies, O.7
-
33
-
-
0027142440
-
Conventional b cells, not B1 cells, are the source of autoantibodies in chronic graft-versus-host disease
-
Reap EA, Sobel ES, Jennette JC, Cohen PL, Eisenberg RA: Conventional B cells, not B1 cells, are the source of autoantibodies in chronic graft-versus-host disease. J Immunol 151:7316, 1993
-
(1993)
J Immunol
, vol.151
, pp. 7316
-
-
Reap, E.A.1
Sobel, E.S.2
Jennette, J.C.3
Cohen, P.L.4
Eisenberg, R.A.5
-
34
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457, 1958
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 457
-
-
Kaplan, E.L.1
Meier, P.2
-
35
-
-
0030587828
-
Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells
-
Blazar BR, Sharpe AH, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Korngold R, Vallera DA: Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells. J Immunol 157:3250, 1996
-
(1996)
J Immunol
, vol.157
, pp. 3250
-
-
Blazar, B.R.1
Sharpe, A.H.2
Taylor, P.A.3
Panoskaltsis-Mortari, A.4
Gray, G.S.5
Korngold, R.6
Vallera, D.A.7
-
36
-
-
0030019716
-
Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production
-
Taub DD, Ortaldo JR, Turcovski-Corrales SM, Key ML, Longo DL, Murphy WJ: Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J Leukoc Biol 59:81, 1996
-
(1996)
J Leukoc Biol
, vol.59
, pp. 81
-
-
Taub, D.D.1
Ortaldo, J.R.2
Turcovski-Corrales, S.M.3
Key, M.L.4
Longo, D.L.5
Murphy, W.J.6
-
37
-
-
0029417004
-
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
-
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811, 1995
-
(1995)
Science
, vol.270
, pp. 1811
-
-
Cocchi, F.1
DeVico, A.L.2
Garzino-Demo, A.3
Arya, S.K.4
Gallo, R.C.5
Lusso, P.6
-
38
-
-
0030933792
-
Chemokines and HIV: A remarkable synergism
-
Moser B: Chemokines and HIV: A remarkable synergism. Trends Microbiol 5:88, 1997
-
(1997)
Trends Microbiol
, vol.5
, pp. 88
-
-
Moser, B.1
-
39
-
-
15844428546
-
Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection
-
Tedla N, Palladinetti P, Kelly M, Kumar RK, DiGirolamo N, Chattophadhay U, Cooke B, Truskett P, Dwyer J, Wakefield D, Lloyd A: Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection. Am J Pathol 148:1367, 1996
-
(1996)
Am J Pathol
, vol.148
, pp. 1367
-
-
Tedla, N.1
Palladinetti, P.2
Kelly, M.3
Kumar, R.K.4
DiGirolamo, N.5
Chattophadhay, U.6
Cooke, B.7
Truskett, P.8
Dwyer, J.9
Wakefield, D.10
Lloyd, A.11
-
40
-
-
0030873653
-
Role of pro-inflammatory cytokines and beta-chemokines in controlling HIV replication
-
Vicenzi E, Biswas P, Mengozzi M, Poli G: Role of pro-inflammatory cytokines and beta-chemokines in controlling HIV replication. J Leukoc Biol 62:34, 1997
-
(1997)
J Leukoc Biol
, vol.62
, pp. 34
-
-
Vicenzi, E.1
Biswas, P.2
Mengozzi, M.3
Poli, G.4
-
41
-
-
0027874409
-
The effects of human recombinant MIP-1 alpha, MIP-1 beta, and RANTES on the chemotaxis and adhesion of T cell subsets
-
Taub DD, Lloyd AR, Wang JM, Oppenheim JJ, Kelvin DJ: The effects of human recombinant MIP-1 alpha, MIP-1 beta, and RANTES on the chemotaxis and adhesion of T cell subsets. Adv Exp Med Biol 351:139, 1993
-
(1993)
Adv Exp Med Biol
, vol.351
, pp. 139
-
-
Taub, D.D.1
Lloyd, A.R.2
Wang, J.M.3
Oppenheim, J.J.4
Kelvin, D.J.5
-
42
-
-
0027157494
-
Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1α and MIP-1β
-
Taub DD, Conlon K, Lloyd AR, Oppenheim JJ, Kelvin DJ: Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1α and MIP-1β. Science 260:355, 1993
-
(1993)
Science
, vol.260
, pp. 355
-
-
Taub, D.D.1
Conlon, K.2
Lloyd, A.R.3
Oppenheim, J.J.4
Kelvin, D.J.5
-
43
-
-
0027322567
-
Human macrophage inflammatory protein a (MIP-1α) and MIP-1β chemokines attract distinct populations of lymphocytes
-
Schall TJ, Bacon K, Camp RDR, Kaspari JW, Goeddel DV: Human macrophage inflammatory protein a (MIP-1α) and MIP-1β chemokines attract distinct populations of lymphocytes. J Exp Med 177:1821, 1993
-
(1993)
J Exp Med
, vol.177
, pp. 1821
-
-
Schall, T.J.1
Bacon, K.2
Camp, R.D.R.3
Kaspari, J.W.4
Goeddel, D.V.5
-
44
-
-
0028197518
-
Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci
-
Bradley DS, Jennette JC, Cohen PL, Eisenberg RA: Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J Immunol 152:1960, 1994
-
(1994)
J Immunol
, vol.152
, pp. 1960
-
-
Bradley, D.S.1
Jennette, J.C.2
Cohen, P.L.3
Eisenberg, R.A.4
-
45
-
-
0025138736
-
Autoantibodies in chronic graft versus host result from cognate T-B interactions
-
Morris SC, Cheek RL, Cohen PL, Eisenberg RA: Autoantibodies in chronic graft versus host result from cognate T-B interactions. J Exp Med 171:503, 1990
-
(1990)
J Exp Med
, vol.171
, pp. 503
-
-
Morris, S.C.1
Cheek, R.L.2
Cohen, P.L.3
Eisenberg, R.A.4
-
46
-
-
0025014269
-
Allotypespecific immunoregulation of autoantibody production by host B cells in chronic graft-versus host disease
-
Morris SC, Cheek RL, Cohen PL, Eisenberg RA: Allotypespecific immunoregulation of autoantibody production by host B cells in chronic graft-versus host disease. J Immunol 144:916, 1990
-
(1990)
J Immunol
, vol.144
, pp. 916
-
-
Morris, S.C.1
Cheek, R.L.2
Cohen, P.L.3
Eisenberg, R.A.4
-
47
-
-
0029731174
-
Intranasal fluticasone propionate inhibits recovery of chemokines and other cytokines in nasal secretions in allergen-induced rhinitis
-
Weido AJ, Reece LM, Simm TC: Intranasal fluticasone propionate inhibits recovery of chemokines and other cytokines in nasal secretions in allergen-induced rhinitis. Ann Allergy Asthma Immunol 77:407, 1996
-
(1996)
Ann Allergy Asthma Immunol
, vol.77
, pp. 407
-
-
Weido, A.J.1
Reece, L.M.2
Simm, T.C.3
-
48
-
-
0030441564
-
Chemokine-leukocyte interactions. The voodoo that they do so well
-
Taub DD: Chemokine-leukocyte interactions. The voodoo that they do so well. Cytokine Growth Factor Rev 7:355, 1996
-
(1996)
Cytokine Growth Factor Rev
, vol.7
, pp. 355
-
-
Taub, D.D.1
-
49
-
-
0030045179
-
Expression and regulation of chemokines in bacterial pneumonia
-
Standiford TJ, Kunkel SL, Greenberger MJ, Laichalk LL, Stricter RM: Expression and regulation of chemokines in bacterial pneumonia. J Leukoc Biol 59:24, 1996
-
(1996)
J Leukoc Biol
, vol.59
, pp. 24
-
-
Standiford, T.J.1
Kunkel, S.L.2
Greenberger, M.J.3
Laichalk, L.L.4
Stricter, R.M.5
|