Expression of interferon-γ by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity

Experimental Hematology

Volumn 27, Issue 5, 1999, Pages 895-903

  Yu, Jian Mei ^a   Emmons, Robert V B ^a   Hanazono, Yutaka ^a   Sellers, Stephanie ^a   Young, Neal S ^a   Dunbar, Cynthia E ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Animal models; Aplastic anemia; Bone marrow; Bone marrow failure; Hematopoiesis

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APLASTIC ANEMIA; ARTICLE; AUTOCRINE EFFECT; BONE MARROW CULTURE; BONE MARROW SUPPRESSION; CELL ACTIVITY; CELL POPULATION; COCULTURE; COLONY FORMING UNIT C; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RETROVIRUS; STROMA CELL;

ANIMALS; BASE SEQUENCE; CELL DIVISION; COCULTURE TECHNIQUES; DNA PRIMERS; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; RETROVIRIDAE; STROMAL CELLS; TRANSDUCTION, GENETIC;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0032921592     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00009-0     Document Type: Article

References (35)

1. Gallin J.I., Farber J.M., Holland S.M., Nutman T.B. Interferon-γ in the management of infectious diseases. Ann Intern Med. 123:1995;216.
2. Young N.S. Autoimmunity and its treatment in aplastic anemia. Ann Intern Med. 126:1996;166.
3. Young N.S., Maciejewski J.P. The pathophysiology of acquired aplastic anemia. N Engl J Med. 336:1997;1365.
4. Nistico A., Young N.S. γ-interferon gene expression in the bone marrow of patients with aplastic anemia. Ann Intern Med. 120:1994;463.
5. Nakao S., Yamaguchi M., Shiobara S. Interferon-γ gene expression in unstimulated bone marrow mononuclear cells predicts a response to cyclosporine therapy in aplastic anemia. Blood. 79:1992;2532.
6. Hinterberger W., Adolf G., Aichinger G., Dudczak R., Geissler K., Hocker P., Huber C., Kalhs P., Koller U., Lechner K.et al. Further evidence for lymphokine overproduction in severe aplastic anemia. Blood. 72:1988;266.
7. Torok-Storb B., Johnson G.G., Bowden R., Storb R. γ-interferon in aplastic anemia. inability to detect significant levels in sera or demonstrate hematopoietic suppressing activity Blood. 2:1987;629.
8. Selleri C., Maciejewski J.P., Sato T., Young N.S. Interferon-γ constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood. 87:1996;4149.
9. Rathburn R.K., Faulkner G.R., Ostroski M.H., Christianson T.A., Hughes G., Jones G., Cahn R., Maziarz R., Royle G., Keeble W.et al. Inactivation of the Fanconi anemia group C gene augments interferon-γ-induced apoptotic responses in hematopoietic cells. Blood. 90:1997;974.
10. Selleri C., Sato T., Anderson S., Young N.S., Maciejewski J.P. Interferon-γ and tumor necrosis factor-α suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol. 165:1995;538.
11. Selleri C., Sato T., Del Vecchio L., Luciano L., Barrett A.J., Rotoli B., Young N.S., Maciejewski J.P. Involvement of fas-mediated apoptosis in the inhibitory effects of interferon in chronic myelogenous leukemia. Blood. 89:1997;957.
12. Maciejewski J.P., Selleri C., Sato T., Anderson S., Young N.S. A severe and consistent deficit in marrow and circulating primitive hematopoietic cells (long-term culture-initiating cells) in acquired aplastic anemia. Blood. 88:1996;1983.
13. Gray P.W., Goeddel D.V. Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A. 80:1983;5842.
14. Cassel A., Cottler-Fox M., Doren S., Dunbar C.E. Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp Hematol. 21:1993;585.
15. Danos O., Mulligan R.C. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci U S A. 85:1988;6460.
16. Soma T., Yu J.M., Dunbar C.E. Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-β but not macrophage inflammatory protein-1α activities. Blood. 87:1996;4561.
17. Bodine D.M., Crosier P.S., Clark S.C. Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture. Blood. 78:1991;914.
18. Bodine D.M., Karlsson S., Nienhuis A.W. Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci U S A. 86:1989;8897.
19. Till J.E., McCullough E.A., Siminovitch L. A stochastic model of stem cell proliferation based on the growth of spleen colony-forming cells. Proc Natl Acad Sci U S A. 51:1964;29.
20. Harrison D.E., Jordan C.T., Zhong R.K., Astle C.M. Primitive hemopoietic stem cells. direct assay of most productive repopulation with simple binomial, correlation and covariance calculations Exp Hematol. 21:1993;206.
21. Harrison D.E. Competitive repopulation. a new assay for long term stem cell capacity Blood. 55:1980;77.
22. Harrison D.E., Astle C.M., Lerner C. Number and continuous proliferation pattern of transplanted primitive immunohematopoietic stem cells. Proc Natl Acad Sci U S A. 85:1988;822.
23. Harrison D.E., Zhong R.K. The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation. Proc Natl Acad Sci U S A. 89:1992;10134.
24. Broxmeyer H., Lu L., Platzer E., Feit C., Juliano L., Rubin B. Comparative analysis of the influences of human γ,α, and β interferons on human multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol. 131:1983;1300.
25. Kawano Y., Takaue Y., Hirao A., Abe T., Saito S.-I., Matsunaga K., Watanabe T., Hirose M., Ninomiya T., Kuroda Y.et al. Synergistic effect of recombinant interferon-γ and interleukin-3 on the growth of immature human hematopoietic progenitors. Blood. 77:1991;2118.
26. Falkner E., Maurer-Fogy I. Recombinant interferon-γ for the therapy of immunological and oncological diseases. J Biotechnol. 46:1996;155.
27. Joklik W.K. Interferons. Fields B.N., Knipe D.M., Chanock R.M., Hirsch M.S., Monath T.P., Roizman B. Fields Virology. 2nd ed:1990;Raven Press, New York. 383-410pp.
28. Schneider L.C., Baz Z., Zarcone C., Zurakowski D. Long-term therapy with recombinant interferon-γ (rIFN-gamma) for atopic dermatitis. Ann Allergy Asthma Immunol. 80:1998;263.
29. Bemiller L.S., Roberts D.H., Starko K.M., Curnutte J.T. Safety and effectiveness of long-term interferonγ therapy in patients with chronic granulomatous disease. Blood Cell Mol Dis. 21:1995;239.
30. Young H.A., Klinman D.M., Reynolds D.A., Grzegorzewski K.J., Nii A., Ward J.M., Winkler-Pickett R.T., Ortaldo J.R., Kenny J.J., Komschlies K.L. Bone marrow and thymus expression of interferon-γ results in severe B-cell lineage reduction T-cell lineage alterations and hematopoietic progenitor deficiencies. Blood. 89:1997;583.
31. Eng V.M., Car B.D., Schnyder B., Lorenz M., Lugli S., Aguet M., Anderson T.D., Ryffel B., Quesniaux V.F.J. The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon-γ in vivo. J Exp Med. 181:1995;1893.
32. Gordon M.Y., Riley G.P., Watt S.M., Greaves M.F. Compartmentalization of a haematopoietic growth factor (GM-CSF) in the bone marrow microenvironment. Nature. 326:1987;403.
33. Camejo E.H., Rosengren B., Camejo G., Sartipy P., Fager G., Bondjers G. Interferon-γ binds to extracellular matrix chondroitin-sulfate proteoglycans, thus enhancing its cellular response. Arterioscler Thromb Vasc Biol. 15:1995;1456.
34. Maciejewski J.P., Hibbs J.R., Anderson S., Katevas P., Young N.S. Bone marrow and peripheral blood phenotype in patients with bone marrow failure. Exp Hematol. 22:1994;1102.
35. Zoumbos N.C., Gascon P., Trost S., Djeu J.Y., Young N. Circulating activated suppressor T lymphocytes in aplastic anemia. N Engl J Med. 312:1985;257.