Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the α 2A-adrenoceptor

British Journal of Pharmacology

Volumn 140, Issue 2, 2003, Pages 347-358

  Peltonen, Juha M ^a   Nyrönen, Tommi ^b,c   Wurster, Siegfried ^d   Pihlavisto, Marjo ^a   Hoffrén, Anna Marja ^d   Marjamäki, Anne ^a   Xhaard, Henri ^b   Kanerva, Liisa ^a   Savola, Juha Matti ^d   Johnson, Mark S ^b   Scheinin, Mika ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c IT Center for Science   (Finland)

^d Oy Juvantia Pharma Ltd   (Finland)

Author keywords

2A Adrenoceptors; Agonist docking; Catecholamines; G protein activation; Ligand binding; Molecular modelling; Receptor activation

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; APRACLONIDINE; BRIMONIDINE; CLONIDINE; CYSTEINE; DOPAMINE; IMIDAZOLE DERIVATIVE; NORADRENALIN; NORFENEFRINE; OCTOPAMINE; PHENETHYLAMINE DERIVATIVE; PHENYLETHANOLAMINE; SERINE; UK 14 304;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENANTIOMER; FEMALE; GENETIC TRANSFECTION; LIGAND BINDING; MUTANT; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ADRENERGIC AGONISTS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATECHOLAMINES; CHO CELLS; CRICETINAE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IDAZOXAN; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN STRUCTURE, TERTIARY; QUINOXALINES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2; SEQUENCE HOMOLOGY, AMINO ACID; SULFUR RADIOISOTOPES; TRITIUM;

EID: 10744228042     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705439     Document Type: Article

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