Differential contribution of two serine residues of wild type and constitutively active β2-adrenoceptors to the interaction with β2-selective agonists

British Journal of Pharmacology

Volumn 121, Issue 6, 1997, Pages 1059-1064

  Kikkawa, Hideo ^a,b   Kurose, Hitoshi ^a   Isogaya, Masafumi ^a   Sato, Yoji ^a   Nagao, Taku ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

2 adrenoceptor; ( ) Salbutamol; ( ) Salmeterol; Adenlyl cyclase activity; Constitutively active receptor; Full agonist; Partial agonist; Subtype selectivity; TA 2005

Indexed keywords

ADENYLATE CYCLASE; AMINO ACID; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 3 ADRENERGIC RECEPTOR; CARMOTEROL; CYANOPINDOLOL I 125; ISOPRENALINE; MUTANT PROTEIN; SALBUTAMOL; SALMETEROL; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CHO CELLS; COS CELLS; CRICETINAE; ENZYME ACTIVATION; IODINE RADIOISOTOPES; IODOCYANOPINDOLOL; MUTAGENESIS, SITE-DIRECTED; PINDOLOL; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS; SERINE;

EID: 0030740473     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701229     Document Type: Article

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