Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human β2-adrenoceptor contributes to agonist binding and receptor activation

British Journal of Pharmacology

Volumn 128, Issue 2, 1999, Pages 272-274

  Sato, Takayuki ^a   Kobayashi, Hiroyuki ^a,b   Nagao, Taku ^a   Kurose, Hitoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Discovery Research Laboratory   (Japan)

Author keywords

2 adrenoceptor; ( ) isoprenaline; Catechol hydroxyl group; Ser203; Serine residue

Indexed keywords

ALANINE; BETA 2 ADRENERGIC RECEPTOR; BRONCHODILATING AGENT; CYCLIC AMP; ISOPRENALINE; SERINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; HUMAN; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANIMAL; CHO CELL; COMPARATIVE STUDY; DRUG EFFECT; GENETICS; HAMSTER; KINETICS; METABOLISM; MUTATION; PHYSIOLOGY; RAT;

ADRENERGIC ALPHA-AGONISTS; ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; ISOPROTERENOL; KINETICS; MUTATION; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SERINE;

EID: 0032586276     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702813     Document Type: Article

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