Modeling and mutagenesis of the human α1a-adrenoceptor: Orientation and function of transmembrane helix V sidechains

Receptors and Channels

Volumn 4, Issue 3, 1996, Pages 165-177

  Wetzel, J M ^a   Salon, J A ^a   Tamm, J A ^a   Forray, C ^a   Craig, D ^a   Nakanishi, H ^a,b   Cui, W ^a   Vaysse, P J J ^a   Chiu, G ^a,c   Weinshank, R L ^a   Hartig, P R ^d   Branchek, T A ^a   Gluchowski, C ^a  

^a H LUNDBECK A S   (Denmark)

^b Molecumetics Ltd   (United States)

^c FMC CORPORATION   (United States)

^d DUPONT COMPANY   (United States)

Author keywords

Activation mechanism; Alpha adrenoceptor; G protein coupled receptor; Homology modeling; Ligand receptor interaction; Site directed mutagenesis

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; BACTERIORHODOPSIN; HYDROXYL GROUP; INOSITOL PHOSPHATE; LIGAND; NORADRENALIN; PRAZOSIN;

ARTICLE; BINDING AFFINITY; HUMAN; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; ORIENTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; ROTATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PRAZOSIN; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0030461873     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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