Three-dimensional models of α(2A)-adrenergic receptor complexes provide a structural explanation for ligand binding

Journal of Biological Chemistry

Volumn 274, Issue 33, 1999, Pages 23405-23413

  Salminen, Tiina ^a   Varis, Minna ^a   Nyrönen, Tommi ^a,b   Pihlavisto, Marjo ^c   Hoffrén, Anna Marja ^d   Lönnberg, Tuomas ^d   Marjamäki, Anne ^c   Frang, Heini ^c   Savola, Juha Matti ^d   Scheinin, Mika ^c   Johnson, Mark S ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b IT Center for Science   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d Oy Juvantia Pharma Ltd   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BACTERIORHODOPSIN; BRIMONIDINE; CLONIDINE; NORADRENALIN; OXYMETAZOLINE; RHODOPSIN;

ALKYLATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

ANIMALS; BACTERIORHODOPSINS; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, ALPHA-2;

ANIMALIA;

EID: 0033551828     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.33.23405     Document Type: Article

References (28)

1. Henderson, R., Baldwin, J. M., Ceska, T. A., Zemlin, F., Backmann, E., and Downing, K. H. (1990) J. Mol. Biol. 213, 899-929
2. Schertler, G. F. X., Villa, C., and Henderson, R. (1993) Nature 362, 770-772
3. Pebay-Peyroula, E., Rummel, G., Rosenbusch, J. P., and Landau, E. (1997) Science 277, 1676-1681
4. Unger, V. M., Hargrave, P. A., Baldwin, J. M., and Schertler, G. F. X. (1997) Nature 388, 203-206
5. Baldwin, J. M., Schertler, G. F. X., and Unger, V. M. (1997) J. Mol. Biol. 272, 144-164
6. Scheer, A., Fanelli, F., Costa, T., De Benedetti, P. G., and Cotecchia, S. (1996) EMBO J. 15, 3566-3578
7. Schwartz, T. W. (1994) Curr. Opin. Biotechnol. 5, 434-444
8. Samana, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
9. Marjamäki, A., Frang, H., Pihlavisto, M., Hoffrén, A.-M., Salminen, T., Johnson, M. S., Kallio, J., Javitch, A., and Scheinin, M. (1999) J. Biol. Chem. 274, 21867-21872
10. Marjamäki, A., Pihlavisto, M., Cockcroft, V., Heinonen, P., Savola, J.-M., and Scheinin, M. (1998) Mol. Pharmacol. 53, 370-376
11. Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., and Regan, J. W. (1987) Science 238, 650-656
12. Javitch, J. A., Fu, D., and Chen, J. (1995) Biochemistry 34, 16433-16439
13. Halme, M., Sjöholm, B., Savola, J.-M., and Scheinin, M. (1995) Biochim. Biophys. Acta 1266, 207-214
14. Fraser, C. M., Arakawa, S., McCombie, W. R., and Venter, J. C. (1989) J. Biol. Chem. 264, 11754-11761
15. Šali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
16. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
17. Gerstein, M. (1992) Acta Crystallogr. Sec. A 48, 271-276
18. Goodford, P. J. (1985) J. Med. Chem. 28, 849-857
19. Gasteiger, J., and Marsili, M. (1980) Tetrahedron 36, 3219-3228
20. Goodsell, D. S., and Olson, A. J. (1990) Proteins Struct. Funct. Genet. 8, 195-202
21. Morris, G. M., Goodsell, D. S., Huey, R., and Olson, A. J. (1996) J. Comput. Aided Mol. Des. 10, 293-304
22. Goodsell, D. S., Morris, G. M., and Olson, A. J. (1996) J. Mol. Recognit. 9, 1-5
23. Weiner, S. J., Kollman, P. A., and Case, D. A. (1986) J. Camput. Chem. 7, 230-252
24. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W., and Kollman, P. A. (1995) J. Am. Chem. Soc. 117, 5179-5197; Correction (1996) J. Am. Chem. Soc. 118, 2309
25. Goodsell, D. S., Lauble, H., Stout, C. D., and Olson, A. J. (1993) Proteins Struct. Funct. Genet. 17, 1-10
26. Link, R., Daunt, D., Barsh, G., Chruscinski, A., and Kobilka, B. (1992) Mol. Pharmacol. 42, 16-27
27. Wang, C. D., Buck, M. A., and Fraser, C. M. (1991) Mol. Pharmacol. 40, 168-179
28. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950